So what does this mean if you get a cold sore every year or two? You're more likely to get Alzheimer's?
Basically yes, but the good news is there’s still plenty of time to find a cure before it hits you.
Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
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Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#12Earlier quoted context omitted.
It means you’re not getting enough lysine at those times.
Source on info? Can you supplement with lysine?
Not really efficaceous: https://www.cochrane.org/CD010095/SKIN_measures-preventing-c...
My vet said the same (chronic respiratory problems in cats are often caused by feline herpesvirus). The effect on the cat is at best slight.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#13So according to WHO, 67% of people older than 50 have Herpes 1: https://www.who.int/en/news-room/fact-sheets/detail/herpes-s... How do you account for the disparity between the massive infection rate and the relatively low Alzheimer's rate?
They might not be old enough for it to matter yet, and we might see numbers approaching that 67% as people live longer.
https://www.nia.nih.gov/health/what-causes-alzheimers-diseas...
"Older age does not cause Alzheimer’s, but it is the most important known risk factor for the disease. The number of people with Alzheimer’s disease doubles about every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease." (emphasis mine)
Perhaps if we beat cancer and cardiovascular diseases etc and see human lifespans reaching 100+ years old, we'll see close to 67% of people at that age get Alzheimer's.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#14This is my primary concern with SARSCoV2. Seeing how HPV can manifest in cancer, how HSV-1 can lead to Alzheimer’s, or how VZV (chickenpox) can flare up later in life as Shingles.
Edit: thanks for the helpful information below!
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#15Big if true! This would mean that just as the Gardasil 9 vaccine prevents HPV, which leads to almost all forms of cervical cancer [1] (as well as others), a vaccine for HSV-1 might prevent someone from developing Alzheimer's later in life. There are HSV-2 vaccines in clinical trials [2], but I'm unaware of any HSV-1 vaccines as far along. Please chime in if you are aware! [1] https://www.nccc-online.org/hpvcervical-c…
This paper only shows that brain-like lab grown tissue develops Amyloid-beta plaques (known to occur in patients with AD) to combat mircobial i.e. viral attack. There are a low of assumptions here: (1) Organoid tissue represents human-brain. Human (and mammalian) brain is a much more complex entity to be even remotely similar to this. (2) We do not know how amyloid-beta plaques are related to Alzheimer's Disease (AD)…
All true, correlation does not equal causation, but it's still fun to speculate when it looks like there might be a relatively inexpensive path (ie a vaccine we're going to develop anyway) to success.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#16So according to WHO, 67% of people older than 50 have Herpes 1: https://www.who.int/en/news-room/fact-sheets/detail/herpes-s... How do you account for the disparity between the massive infection rate and the relatively low Alzheimer's rate?
I don't think one should extrapolate this study on a lab-grown human-like tissue to mammals like rodents in the first place. Extrapolation to humans is even more bizzare.
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#17[deleted]
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#18Big if true! This would mean that just as the Gardasil 9 vaccine prevents HPV, which leads to almost all forms of cervical cancer [1] (as well as others), a vaccine for HSV-1 might prevent someone from developing Alzheimer's later in life. There are HSV-2 vaccines in clinical trials [2], but I'm unaware of any HSV-1 vaccines as far along. Please chime in if you are aware! [1] https://www.nccc-online.org/hpvcervical-c…
There is correlation between zoster vaccine and herpes simplex.
This has correlation to lesser the outbreaks or make them stop altogether. I can attest to that.
This is what some specialist doctors recommend for patient with bad herpes outbreaks.
I guess this would be already good starting point.
Example source (pdf): https://proceedings.med.ucla.edu/wp-content/uploads/2016/03/...
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#19HSV always seemed particularly poorly understood in the society to me, e.g. with many people getting it as children due to careless parents/extended family, and the benign branding of "cold sore" as if it is related to a cold. Given that the vaccine for 1 or 2 has proved to be extremely challenging, always wondered if the public simply being more well-informed on this topic could help reduce the incidence in the population.
Asymptomatic shedding of HSV has to be considered, too. "Transmission commonly occurs from contact with an infected partner who does not have visible lesions and who may not know that he or she is infected. In persons with asymptomatic HSV-2 infections, genital HSV shedding occurs on 10.2% of days, compared to 20.1% of days among those with symptomatic infections." (https://www.cdc.gov/std/herpes/stdfact-herpes-detailed.htm)
Re: Using human brain tissue in lab, researchers show herpes link to Alzheimer’s
#20Earlier quoted context omitted.
This paper only shows that brain-like lab grown tissue develops Amyloid-beta plaques (known to occur in patients with AD) to combat mircobial i.e. viral attack. There are a low of assumptions here: (1) Organoid tissue represents human-brain. Human (and mammalian) brain is a much more complex entity to be even remotely similar to this. (2) We do not know how amyloid-beta plaques are related to Alzheimer's Disease (AD)…
All true, correlation does not equal causation, but it's still fun to speculate when it looks like there might be a relatively inexpensive path (ie a vaccine we're going to develop anyway) to success.
It is fun indeed to speculate that. One could even use this line of "imagination" to get big Pharma interested in investing in this line of fundamental research which, as we have been reminded more recently, is extremely crucial.