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Chloroquine phosphate has shown apparent efficacy in treating Covid-19

ncbi.nlm.nih.gov

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Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#111

Post by benzible »

khafra wrote: post #48
_-___________-_ wrote: post #42

Earlier quoted context omitted.

It's an analogue of quinine, which tonic water nowadays may contain varying (quite small) amounts of, depending on brand etc. G&Ts almost certainly won't have any effect on your susceptibility to infection nor your prognosis once infected. But they might help with (or make worse?) the anxiety associated with the panic.

Tonic water can contain up to 83mg/L actual quinine. Three 2L bottles of tonic water could get you 500mg, a therapeutic dose of quinine. Unfortunately, I have not found any place that manufacturers note how much quinine is in their tonic water.

Be careful - an overdose of quinine can cause cinchonism, which has some unpleasant symptoms: https://en.wikipedia.org/wiki/Cinchonism

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#112

Post by grogenaut »

hackeerTwo wrote: post #51
yorwba wrote: post #37

Earlier quoted context omitted.

I checked the most recent result from that search: http://www.chictr.org.cn/showproj.aspx?proj=50843 At the very bottom, it says "original data will be published on web-based public database in 6 months after the research" which is a bit disappointing.

Can anyone mention a reasonable explanation for the 6-month delay? All I can think is that they want to prevent irresponsible purchases thus only including it in treatment guidelines for now.

maybe they forgot to change that page on their powerpoint template? I know I've done it.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#113

Post by rscho »

3fe9a03ccd14ca5 wrote: post #110
rscho wrote: post #46

Earlier quoted context omitted.

Thank you for this reasonable view. Those last few days, I have seen a great many people here piling on chloroquine and aggressively promoting it to others. Those people were sometimes alledged scientists. This is worrying. Some countries have it in their emergency guidelines, yes. But is it beyond reasonable doubt that quinine derivatives are useful in humans? No. Absolutely not. People are incredibly prompt to jump…

“Some countries” is of course South Korea, which has had one of the lowest mortality rates of covid19. 1. http://m.koreabiomed.com/news/articleView.html?idxno=7428

And of course, you provide evidence of a causal link to quinine derivatives. This is ridiculous.

If you really knew the scientific state of clinical research, you would be far more skeptical.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#114

Post by lultimouomo »

roenxi wrote: post #67
ethbro wrote: post #47

Earlier quoted context omitted.

That still causes shortages. It's just increasing the ultimate gray market resale price. Looking at potential death puts gray market buyers in a weak negotiating position.

There is a shortage either way; there hasn't been a change in the amount of the drug or the number of people who want it in either scenario. If anything, the price going up will increase production and the shortage will lessen as fast as the logistics chain can manage. Basically instead of people choosing where it goes a government agency/hospital system chooses where it goes. After the CDC testing debacle, hopefully…

There will be a shortage of ICU beds too. Would you like to allocate them to the best payer as well?

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#115

Post by m0zg »

usrusr wrote: post #69
m0zg wrote: post #22

Earlier quoted context omitted.

Yeah, a local hospital was approved for vaccine testing today. Timeline for completing the tests? 13 months.

It makes sense that vaccines need more careful assessment before rollout than treatment pharmaceuticals. When the medical infrastructure has reached triage grade saturation, even coin toss treatment candidates could become rational if they can run in parallel to conventional treatment. Exposing the still healthy to a vaccine is an entirely different risk calculation. A reasonably opportunity to throw money at the pro…

We are potentially looking at upwards of a half a million people dead. 13 months makes zero sense no matter how you slice it.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#116

Post by djrogers »

jennyyang wrote: post #92
blacksqr wrote: post #84

South Korea experts recommend anti-HIV, anti-malaria drugs for COVID-19 [1] Mentioned: Kaletra, an anti-HIV medication that includes the drugs lopinavir and ritonavir. Hydroxychloroquine, sold under the brand name Plaquenil. [1] https://www.upi.com/Top_News/World-News/2020/03/12/South-Kor...

According to this verified tweet, Kaletra didn't seem effective (point #5 in the linked images) https://twitter.com/katyw2004/status/1236848300143280128 verification tweet: https://twitter.com/mshah85/status/1237231277251514368

Just lol'd at the concept of a 'verification tweet'... Seriously folks - just because someone on Twitter sounds authoritative, doesn't mean they are spouting facts.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#117

Post by [deleted] »

rscho wrote: post #113
3fe9a03ccd14ca5 wrote: post #110

Earlier quoted context omitted.

“Some countries” is of course South Korea, which has had one of the lowest mortality rates of covid19. 1. http://m.koreabiomed.com/news/articleView.html?idxno=7428

And of course, you provide evidence of a causal link to quinine derivatives. This is ridiculous. If you really knew the scientific state of clinical research, you would be far more skeptical.

[deleted]

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#118

Post by jbourne007 »

hammock wrote: post #99
shoyer wrote: post #5

For a slightly more balanced perspective, try this paper: https://www.sciencedirect.com/science/article/pii/S016635422... : Highlights from that paper (all of which look quite reasonable to me, as a non-expert): • In vitro data suggest that chloroquine inhibits SARS Cov-2 replication. • In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models. • Chloroq…

Thanks for this summary. >The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data Which are...?

The trial numbers are referenced in the sciencedirect paper but I really wish they would share the outcomes of the trials. WHO should be on this one would think!

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#119

Post by jbourne007 »

biolurker1 wrote: post #97
Sylamore wrote: post #3

I've been watching the videos in this youtube channel today, where the last couple of videos have talked about this finding : https://youtu.be/U7F1cnWup9M and https://youtu.be/vE4_LsftNKM Basically the goal is to allow zinc to get into a cell, it needs a helper to get inside the cell (a Zinc Ionophore). Apparently based on the 2nd video, Hydroxychloroquine is even more effective than Chloroquine. It's really importan…

yes they tried it on ICU patients with better outcomes

Do you have a reference or source for this? Thx.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#120

Post by jbourne007 »

Sylamore wrote: post #3

I've been watching the videos in this youtube channel today, where the last couple of videos have talked about this finding : https://youtu.be/U7F1cnWup9M and https://youtu.be/vE4_LsftNKM Basically the goal is to allow zinc to get into a cell, it needs a helper to get inside the cell (a Zinc Ionophore). Apparently based on the 2nd video, Hydroxychloroquine is even more effective than Chloroquine. It's really importan…

One would think there would be easier ways to get Zinc into a cell. Does one really have to go for a drug for this? There have to be alternatives?
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