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Chloroquine phosphate has shown apparent efficacy in treating Covid-19

ncbi.nlm.nih.gov

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Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#101

Post by herf »

Paper's main source seems to be a news briefing in Chinese.

Here's google translate: "We organized more than a dozen hospitals in Beijing, Guangdong and Hunan provinces to jointly evaluate the safety and effectiveness of chloroquine phosphate in the treatment of new coronary pneumonia. In the clinic, we are very sure to see the curative effect, whether it is from the rate of exacerbation, antipyretic phenomenon or the image improvement time of the lungs, the negative time and negative rate of viral nucleic acid, and the shortening of the disease course, and a series of indicators, systematically Based on comprehensive research, the medication group was better than the control group. For example, a patient in Beijing was admitted to the hospital on the 4th day of the onset of disease at the age of 54. One week after taking the medicine, the nucleic acid turned negative, and all the indicators improved, meeting the criteria for release and isolation."

"Audio transcript of the news briefing held by the State Council of China on February 17, 2020. The National Health Commission of the People's Republic of China. http://www.nhc.gov.cn/xcs/yqfkdt/202002/f12a62d10c2a48c6895c... (accessed February 18, 2020). (in Chinese)"

Third reference in https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_202...

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#102

Post by exabrial »

OJFord wrote: post #93
khafra wrote: post #48

Earlier quoted context omitted.

Tonic water can contain up to 83mg/L actual quinine. Three 2L bottles of tonic water could get you 500mg, a therapeutic dose of quinine. Unfortunately, I have not found any place that manufacturers note how much quinine is in their tonic water.

That'd need at least 2L gin to wash it down with though, which could be problematic depending on the frequency of your 500mg prescription.

challenge accepted.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#103

Post by beagle3 »

kkarakk wrote: post #88
beagle3 wrote: post #33

Earlier quoted context omitted.

One of the side effects of zinc overdose is loss of sense of smell, sometimes permanently. Please research all aspects before use.

you get prepackaged 25mg tablets of zinc for bodybuilding. most people will get those and the recommended dosage is one every night. i don't think anyone except hypochondriacs are in danger of zinc overdose

I was told by a lady behind me in line in the store yesterday (who had taken 10 packs) that she intends to take 1 per day but if she feels bad she’ll take 4 per day until she overcomes the covid.

There is enough stupidity around in normal times, and now is worse.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#104

Post by lowdest »

0xff00ffee wrote: post #100

Chloroquine is a really interesting drug because it is derived from quinine which is one of those "early history medicine man/woman" kinda things (Quechas) that turned out to be effective for two things: antiviral properties and great taste. * It was used for centuries to combat malaria until it recently (~10yrs) became ineffective (I took some in the 80's for a year while working in Central America and had amazing d…

More gin and tonic == less coronavirus. Got it. That's some specious logic I can get behind.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#105

Post by cbhl »

Joker_vD wrote: post #94
_m5dp wrote: post #15

Earlier quoted context omitted.

I'm fairly certain finding the vaccine is really quite easy to develop and has been done by multiple companies small and large already. The main issue is to do the clinical trials and get it approved and mass produced in a timely fashion. These trials and the validation can take about a year. Here is the official list of currently being developed covid19 vaccines (all in pre-clinical stage) https://www.who.int/bluepr…

How comes, then, that every year there is a flu vaccine ready before the season starts?

They start making the flu vaccine the year before. It takes six to nine months, and lots of chicken eggs.

Here's a Planet Money rerun that talks about how they make the regular flu vaccine: https://www.npr.org/2020/03/06/812943907/episode-977-wheres-...

Transcript: https://www.npr.org/transcripts/812943907

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#106

Post by CydeWeys »

_-___________-_ wrote: post #41
yorwba wrote: post #37

Earlier quoted context omitted.

I checked the most recent result from that search: http://www.chictr.org.cn/showproj.aspx?proj=50843 At the very bottom, it says "original data will be published on web-based public database in 6 months after the research" which is a bit disappointing.

What would be the motivation for that 6 month delay? Cynically it only seems like a way to grab headlines without any possibility of informed criticism, but I really want to believe that there are other possible motivations!

Maybe it would take a lot more work to get the data into a publishable format and they don't think that's their highest priority right now? Being charitable here.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#107

Post by rfoo »

_-___________-_ wrote: post #41
yorwba wrote: post #37

Earlier quoted context omitted.

I checked the most recent result from that search: http://www.chictr.org.cn/showproj.aspx?proj=50843 At the very bottom, it says "original data will be published on web-based public database in 6 months after the research" which is a bit disappointing.

What would be the motivation for that 6 month delay? Cynically it only seems like a way to grab headlines without any possibility of informed criticism, but I really want to believe that there are other possible motivations!

Most likely because this is a general notice and when situations are boring their bureaucracy can take them 6 months.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#109

Post by sterwill »

sudosysgen wrote: post #85
mnw21cam wrote: post #83

Earlier quoted context omitted.

As someone who has taken uncoated chloroquine tablets mumble years ago, the taste is one of the most foul bitter over-riding tastes one will ever encounter. No amount of sugar mixed in with it took the edge off the taste. The only thing that did it was when they coated the tablets, preventing the chloroquine from touching the tongue.

A surprising amount of medicines have this incredibly foul taste. I was forced to take oseltamivir during the H1N1 epidemic, and I had to share a pill once (two of my siblings needed a half dose). It tasted so incredibly bitter and just mouth-wrenching

The worst taste experience I ever had was when I accidentally bit down on an ibuprofen gel cap before swallowing it with a small mouthful of room temperature coffee (it was all I had at my office desk). Wow... it instantly numbed the back of my mouth and throat and tasted like volatile chemical waste. I washed it all down as fast as I could with more coffee but that taste and tingly sensation stuck around for 20 minutes.

The ibuprofen did its job though.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#110

Post by 3fe9a03ccd14ca5 »

rscho wrote: post #46
shoyer wrote: post #5

For a slightly more balanced perspective, try this paper: https://www.sciencedirect.com/science/article/pii/S016635422... : Highlights from that paper (all of which look quite reasonable to me, as a non-expert): • In vitro data suggest that chloroquine inhibits SARS Cov-2 replication. • In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models. • Chloroq…

Thank you for this reasonable view. Those last few days, I have seen a great many people here piling on chloroquine and aggressively promoting it to others. Those people were sometimes alledged scientists. This is worrying. Some countries have it in their emergency guidelines, yes. But is it beyond reasonable doubt that quinine derivatives are useful in humans? No. Absolutely not. People are incredibly prompt to jump…

“Some countries” is of course South Korea, which has had one of the lowest mortality rates of covid19.

1. http://m.koreabiomed.com/news/articleView.html?idxno=7428

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