Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Chloroquine phosphate has shown apparent efficacy in treating Covid-19

ncbi.nlm.nih.gov

Post reply on HN
Print view View original

11–20 of 174 posts

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#11

Post by Cantbekhan »

This is old news by this time. As I commented on previous threads. https://news.ycombinator.com/item?id=22534339

Yes chloroquine has been shown effective in vitro (https://www.nature.com/articles/s41422-020-0282-0). Yes hydroxichloroquine has been shown effective in vitro very recently as well (https://academic.oup.com/cid/advance-article/doi/10.1093/cid...).

Yes both compounds are already actively being used and approved for use by Asian and EU countries against Covid19:

Here are the Netherlands treatment guidelines (in Dutch): https://lci.rivm.nl/covid-19/bijlage/medicamenteuze-behandel...

Here are the Italy treatment guidelines (in Italian): http://www.simit.org/medias/1555-covid19-linee-guida-trattam...

How they found out about it: https://www.jqknews.com/news/388543-The_novel_coronavirus_pn...

Approval and recommendation of the chinese: https://pubmed.ncbi.nlm.nih.gov/32075365-expert-consensus-on... https://pubmed.ncbi.nlm.nih.gov/32074550-breakthrough-chloro...

I don't think there is much doubt left about it's efficiency at this stage. Hydroxichloroquine is much safer than chloroquine and it's just a 5 day course at pretty low dosage (2x400mg on day1 as a charge dose, then 2x200mg for 4 days).

More importantly, the drug is readily available, mass producded and doesn't cost 300$+/box like lopinavir/ritonavir. This drug isn't also 100% experimental and probably in the 3 digits rangs like remdesivir.

The only real issue is that with a lot of doctors using it, the temporary shortage of the drug could be troublesome for many Lupus patients around the world who depend on Plaquenil for their management.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#14

Post by vijayr02 »

Cantbekhan wrote: post #11

This is old news by this time. As I commented on previous threads. https://news.ycombinator.com/item?id=22534339 Yes chloroquine has been shown effective in vitro ( https://www.nature.com/articles/s41422-020-0282-0 ). Yes hydroxichloroquine has been shown effective in vitro very recently as well ( https://academic.oup.com/cid/advance-article/doi/10.1093/cid... ). Yes both compounds are already actively being used and…

I just posted a story about a vaccine being found. Would be great to know from the experts in this area if the approach they describe in the article makes sense

https://news.ycombinator.com/item?id=22565460

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#15

Post by _m5dp »

vijayr02 wrote: post #14
Cantbekhan wrote: post #11

This is old news by this time. As I commented on previous threads. https://news.ycombinator.com/item?id=22534339 Yes chloroquine has been shown effective in vitro ( https://www.nature.com/articles/s41422-020-0282-0 ). Yes hydroxichloroquine has been shown effective in vitro very recently as well ( https://academic.oup.com/cid/advance-article/doi/10.1093/cid... ). Yes both compounds are already actively being used and…

I just posted a story about a vaccine being found. Would be great to know from the experts in this area if the approach they describe in the article makes sense https://news.ycombinator.com/item?id=22565460

I'm fairly certain finding the vaccine is really quite easy to develop and has been done by multiple companies small and large already. The main issue is to do the clinical trials and get it approved and mass produced in a timely fashion.

These trials and the validation can take about a year.

Here is the official list of currently being developed covid19 vaccines (all in pre-clinical stage)

https://www.who.int/blueprint/priority-diseases/key-action/n...

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#16

Post by vijayr02 »

_m5dp wrote: post #15
vijayr02 wrote: post #14

Earlier quoted context omitted.

I just posted a story about a vaccine being found. Would be great to know from the experts in this area if the approach they describe in the article makes sense https://news.ycombinator.com/item?id=22565460

I'm fairly certain finding the vaccine is really quite easy to develop and has been done by multiple companies small and large already. The main issue is to do the clinical trials and get it approved and mass produced in a timely fashion. These trials and the validation can take about a year. Here is the official list of currently being developed covid19 vaccines (all in pre-clinical stage) https://www.who.int/bluepr…

Thanks for the quick reply.

In the article I referenced, the company says they use a novel plant based method which allows mass production, and expect phase three clinical trials to be completed by November.

The company, Medicago, is not on the list you provided. It also seems to be a Pentagon funded biotech company so trying to understand how credible this news may be (I'm sure there are many unscrupulous companies trying to claim a miracle cure at this point!)

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#17

Post by saagarjha »

allovernow wrote: post #7

Honestly this is a perfect example of a time when laws are excessively restrictive. I should have the right to purchase this drug and use it as a last resort in the case that I or my family are infected. It's not fair to responsible people who are capable of researching safety and dosages to have to pay for the ignorance of others. Especially when this drug is OTC in most of the world. You don't need a medical degree…

What if the drug causes humans to die two weeks after taking it?

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#18

Post by baybal2 »

> • The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data.

Shameless tangent, China has just booted its most competent respiratory disease epidemiologist from heading epidemic control committee for not backing Xi Jinping's "herbal remedies"

https://www.taiwannews.com.tw/en/news/3895540

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#19

Post by lultimouomo »

allovernow wrote: post #7

Honestly this is a perfect example of a time when laws are excessively restrictive. I should have the right to purchase this drug and use it as a last resort in the case that I or my family are infected. It's not fair to responsible people who are capable of researching safety and dosages to have to pay for the ignorance of others. Especially when this drug is OTC in most of the world. You don't need a medical degree…

I'm reasonably sure having hospitals run out of it because it was hoarded by preppers is not a desirable outcome.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#20

Post by 9nGQluzmnq3M »

newsbinator wrote: post #13

I can't seem to find information on whether Chloroquine would be taken prophylactically to be effective, or only after diagnosis and symptoms appear.

This will be a moot point for the foreseeable future, since if this actually works, limited supplies will be redirected to people who are actually infected.
Post reply on HN