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The neuroinvasive potential of SARS-CoV2

ncbi.nlm.nih.gov

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Re: The neuroinvasive potential of SARS-CoV2

#231

Post by crusty »

crusty wrote: post #228
Symmetry wrote: post #121

Earlier quoted context omitted.

I think that different sources are using different definitions of "effective" here. If a simple surgical mask cuts down transmission rates by 50% that isn't anywhere near good enough for health workers working with sick patients every day. But it might still make a significant improvement in your chances of getting infected and, combined with social distancing, might drop the R0 below 1. Hence why Chinese and Korean…

TL:DR: The most effective use of disposable masks for blocking germ transmission is by the people with the germs who might pass them to this without but at risk. Surgical masks are meant to protect surgery patients from the medical staff and the droplet-encased germs they emanate. N95 masks are meant to protect the wearer from particulate matter (harmful dust) in the air, specifically those particles over 30 microns.…

And as to that not our culture comment, I mean it's the American of course who got told to isolate himself on suspicion of infection but decided to go to a group political event across state lines regardless, only to infect at least one other person and lead to further isolation calls for everyone else he came into contact with.

Re: The neuroinvasive potential of SARS-CoV2

#232

Post by TeMPOraL »

drcode wrote: post #62
kaylynb wrote: post #49

Earlier quoted context omitted.

I'm not sure I would call them impractical for everyday wear. I wear N95 masks when commuting during active wildfires. The news always says not to wear them because you won't put them on properly, but it's really not that hard to ensure the fitment is correct. It's not like the construction workers that wear them occupationally are rocket scientists. My partner is more vulnerable to respiratory problems and has alway…

Telling people they should wear masks because they don't put them on properly is like telling people they shouldn't drive cars because some people drive them into trees.

People have to go through 30+ hours of hands-on training, and an exam, before they're allowed to use a car on their own.

It's not just about putting the mask on; it's also about ensuring they swap them out regularly and don't self-infect in the process.

Re: The neuroinvasive potential of SARS-CoV2

#233

Post by bryanrasmussen »

fiter wrote: post #20
aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

This suggests an advantage to purposeful infection by oral/eye rather than accidental by intranasal. It'll be interesting to see what the case fatality rate is when segmented by infection route.

How do you know what infection route it came in by, and how certain is the method for determining the route?

Re: The neuroinvasive potential of SARS-CoV2

#234

Post by gamblor956 »

wbl wrote: post #125
morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

Meanwhile in South Korea everyone has masks. In WWII we built one bomber an hour at one plant, and now we can't figure out how to build millions or billions of masks.

Multiple companies in the US, China, and Europe have announced that they will be producing millions or more masks a month with availability beginning as soon as next week, just 2 months after the virus went global...

It took most of the war for that plant to get to the point of building a bomber an hour.

Re: The neuroinvasive potential of SARS-CoV2

#235

Post by aldanor »

samatman wrote: post #214
tjt wrote: post #57

Earlier quoted context omitted.

This is super scary. Before I read this I was happily thinking hey it's no worse than flu. Now... I'm wishing I didn't live in a huge city riding the subway daily.

When I lived in Chicago I used to practice riding the L without touching anything with my hands. In the Bay I kept up the habit. This is never not a good idea, so no time like the present to get into it.

Or you could just wear cycling gloves.

Re: The neuroinvasive potential of SARS-CoV2

#236

Post by throwanem »

Kiro wrote: post #211
W4ldi wrote: post #68

Earlier quoted context omitted.

'mouth breathing' is actually really bad for you.

How so?

Your nasal passages include structures called "conchae" which, among other purposes, secrete mucus to capture small and potentially disease-carrying particles from incoming air. [1] It's not a perfect defense, of course, but better to have it than not - and when you breathe through your mouth, you don't get the benefit.

[1] https://en.wikipedia.org/wiki/Nasal_concha#Immunological_rol...

Re: The neuroinvasive potential of SARS-CoV2

#237

Post by luckylion »

SubiculumCode wrote: post #216
_rrnv wrote: post #204

Earlier quoted context omitted.

This! It really boggles the mind that officials would discourage wearing masks (even surgical masks). You see, the best way to stop COVID-19 is to thwart its infectious potential. And this is done by two things: everybody wears masks (since nobody knows they are contagious until it's too late) and everybody washes hands constantly. But nooo, no need to panic, this is not Asia, this is The West... Freedom!... x_x

I think that the fear was of a mask shortage. Infected quarantined > Potentially Infected COVID-19 contacts wearing masks > Uninfected wearing masks.

Can someone shed some light on the difficulties of producing the "simple" surgical masks? I'm not talking about something that filters the incoming air, but the lame kind that just reduces the amount of liquids you disperse when breathing, coughing, sneezing etc.

Are they so high tech you can't just ramp up production? And how many months in advance would you need to ramp it up? We're about 3 months in and nobody got the idea to increase production of masks until about a week ago (similar for hand sanitizer, soaps etc)? What am I missing, why is that a thing?

Re: The neuroinvasive potential of SARS-CoV2

#238

Post by rustyminnow »

nimbius wrote: post #224
kaylynb wrote: post #49

Earlier quoted context omitted.

I'm not sure I would call them impractical for everyday wear. I wear N95 masks when commuting during active wildfires. The news always says not to wear them because you won't put them on properly, but it's really not that hard to ensure the fitment is correct. It's not like the construction workers that wear them occupationally are rocket scientists. My partner is more vulnerable to respiratory problems and has alway…

Occupationally I'm a diesel mechanic,so I suppose I could be lumped into the non occupational rocket scientist category. Im learning python. Yes, we wear n95, but we also get OSHA/niosh specific training on fitment, changing, PPE exposure limit, and appropriate environments. You do not. What people are hoping is that an industrial particulate mask is going to somehow prevent the flu or corona, which honestly I have n…

I used to be a residential painter. AIUI (and I could be wrong here) biological and water-based molecules are larger than other chemical molecules so can be stopped by the particulate mask. This is why you can wear a dust-cup when spraying with acrylic (water-based), but need a respirator for oil or lacquer-based paint. TBH I'd expect the n95 to work better for infection than a surgical mask because you can get a better seal to your face

Re: The neuroinvasive potential of SARS-CoV2

#239

Post by geggam »

samatman wrote: post #141
geggam wrote: post #113

Earlier quoted context omitted.

given the longevity of webservices online I bet HN is gone before that day happens

HN was founded in 2007, so per the Lindy Effect we should bet on it being around until 2033. I don't know what your over-under on self-driving cars being prevalent is, so I don't know if this supports your point or not.

Looking at the current infrastructure and the current investment in said infrastructure. I think it’s a safe bet to go out 30 years or more before self driving cars are the norm.

In cities sure. Rural areas not happening. Add the fact people like to drive to Mexico Canada and Alaska I’d call it a non starter.

Example. I have a place where the road on google maps and the place people drive vary because rural Arizona uses washes as roads. Cars driven by humans get stuck.

Re: The neuroinvasive potential of SARS-CoV2

#240

Post by Gene_Parmesan »

refurb wrote: post #145
tjt wrote: post #57

Earlier quoted context omitted.

This is super scary. Before I read this I was happily thinking hey it's no worse than flu. Now... I'm wishing I didn't live in a huge city riding the subway daily.

I don't understand the worry. As of yesterday, China, a country of 1.4B, had 80,000 cases and 3,000 dead. Last year, the US had 36M infected with the flu and 34,000 died.[1] Are you panicking about the flu? [1] https://www.cdc.gov/flu/about/burden/2018-2019.html

Mortality rate of covid19 for people with cancer is estimated at over 6%. My mom has cancer. Every person who gets covid19 but thinks "oh it wasn't that bad" makes it just a little more likely that people like my mom will contract it.

The reason to not panic but be prepared is that humanity has zero immunity to this virus, whereas there's lots of group immunity to influenza. I'm not sure why it's so hard for people to see the issue here.

It's significantly more deadly than the flu. But also, people should probably take influenza more seriously anyways.

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