The neuroinvasive potential of SARS-CoV2 • Hacker News Board

Re: The neuroinvasive potential of SARS-CoV2

#41

Post by rolph » Wed, Mar 04, 2020, 6:13 PM UTC

rolph wrote: post #12

Santosh83 wrote: post #2

I thought papers dealing with this virus were to be made available publicly?

go here: https://sci-hub.se/10.1002/jmv.25728 keep in mind this is a preliminary, the grammar used in this paper needs to be revised so as to avoid as much as possible, people coming to errant conclusions after misinterpreting poorly written phrases. so that means that while reading this paper one should not skim but should take the effort to interpret this paper. there is an absence of references in the abstract, th…

if you head down to page 4 of the paper there is where you will find references to background literature cited regarding "neuroinvasive potential"

[1] Glass WG, Subbarao K, Murphy B, Murphy PM. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 2004;173:4030-4039.

https://doi.org/10.4049/jimmunol.173.6.4030

[11] Li, Y.-C., Bai, W.-Z., Hirano, N., Hayashida, T., Taniguchi, T., Sugita, Y., … Hashikawa, T. (2012). Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication.

https://doi.org/10.1002/cne.23171

Re: The neuroinvasive potential of SARS-CoV2

#42

Post by tdstein » Wed, Mar 04, 2020, 6:13 PM UTC

bluGill wrote: post #17

morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

Or you could donate them to your local hospital since there is a shortage. I’m not sure they would take them, but it’s worth considering.

Re: The neuroinvasive potential of SARS-CoV2

#43

Post by Leary » Wed, Mar 04, 2020, 6:13 PM UTC

bluGill wrote: post #17

morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

Save them right now and have them as an insurance against if things go really bad and you have to go to a crowded place.

Re: The neuroinvasive potential of SARS-CoV2

#44

Post by jcims » Wed, Mar 04, 2020, 6:13 PM UTC

morpheuskafka wrote: post #15

aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I see this a lot but there obviously have to be some kind of effectiveness curve for masks below N95.

Re: The neuroinvasive potential of SARS-CoV2

#45

Post by [deleted] » Wed, Mar 04, 2020, 6:14 PM UTC

bluGill wrote: post #17

morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

[deleted]

Re: The neuroinvasive potential of SARS-CoV2

#46

Post by zapita » Wed, Mar 04, 2020, 6:14 PM UTC

morpheuskafka wrote: post #15

aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

Regular surgical masks won't protect your from inhaling the virus, but they will protect you from rubbing your face and nose 100 times a day with contaminated hands, without even noticing it. I wouldn't dismiss their efficacy.

Re: The neuroinvasive potential of SARS-CoV2

#47

Post by adatavizguy » Wed, Mar 04, 2020, 6:15 PM UTC

sspencer wrote: post #31

liquidforce wrote: post #28

If I understand this correctly, could wearing nose clips and only mouth breathing be an effective strategy to reduce impact?

> It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasally. That seems like the hypothesis they suggest. Interesting implications.

All the people who were made fun of in middle school for being a 'mouth breather' will have the last laugh.

Re: The neuroinvasive potential of SARS-CoV2

#48

Post by Leary » Wed, Mar 04, 2020, 6:16 PM UTC

morpheuskafka wrote: post #15

aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

Surgical masks are effective against droplets from coughing and sneezing.

Re: The neuroinvasive potential of SARS-CoV2

#49

Post by kaylynb » Wed, Mar 04, 2020, 6:16 PM UTC

morpheuskafka wrote: post #15

aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I'm not sure I would call them impractical for everyday wear. I wear N95 masks when commuting during active wildfires. The news always says not to wear them because you won't put them on properly, but it's really not that hard to ensure the fitment is correct. It's not like the construction workers that wear them occupationally are rocket scientists.

My partner is more vulnerable to respiratory problems and has always worn N95 masks when in public during flu season. What's changed now is she gets all kinds of shit from people because they think she somehow hoarded masks away from healthcare workers. We've had boxes N95 masks for years, but now we're assholes for hoarding...

Re: The neuroinvasive potential of SARS-CoV2

#50

Post by peteradio » Wed, Mar 04, 2020, 6:17 PM UTC

majos wrote: post #18

Not a biologist, but reading the paper, the chain of reasoning appears to be summarized in this section: > Taken together, the neuroinvasive propensity has been demonstrated as a common feature of CoVs. In light of the high similarity between SARS-CoV and SARS-CoV2, it is quite likely that SARS-CoV-2 also possesses a similar potential. Based on an epidemiological survey on COVID-19, the median time from the first sym…

You are now breathing manually ... forever.