Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

The neuroinvasive potential of SARS-CoV2

ncbi.nlm.nih.gov

Post reply on HN
Print view View original

21–30 of 298 posts

Re: The neuroinvasive potential of SARS-CoV2

#21

Post by mongol »

bluGill wrote: post #17
morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

For a million dollars - no doubt.

Re: The neuroinvasive potential of SARS-CoV2

#22

Post by SpicyLemonZest »

morpheuskafka wrote: post #15
aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I think there's a legitimate question here. Intuitively, if a non-N95 mask only stops 25% or 50% of incoming viruses, that still seems helpful? It's worth noting that in countries where wearing masks is normalized, making sure the general public can get some is a top priority.

Re: The neuroinvasive potential of SARS-CoV2

#23

Post by dx7tnt »

bluGill wrote: post #17
morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

You could give them to health care workers and be even wealthier.

Re: The neuroinvasive potential of SARS-CoV2

#24

Post by cryoshon »

DailyHN wrote: post #13
newsbinator wrote: post #4

If it did turn out this virus is neuroinvasive and that is what causes acute respiratory problems, how would this be prevented/mitigated/treated, theoretically?

> Considering the potential neuroinvasion of SARS-CoV-2, antiviral therapy should be carried out as early as possible to block its entry into the CNS. Airway inhalation of antiviral agents will be the first choice at the early stage of infection, which will inhibit the replication SARS-CoV-2 in the respiratory tracts and lung and prevent from its subsequent neuroinvasion. It is also urgent to find effective antiviral…

>corticosteroids may have no treatment effect

isn't the point of the corticosteriods to rapidly reduce widespread pulmonary inflammation that would otherwise kill the patient?

Re: The neuroinvasive potential of SARS-CoV2

#25

Post by csears »

newsbinator wrote: post #4

If it did turn out this virus is neuroinvasive and that is what causes acute respiratory problems, how would this be prevented/mitigated/treated, theoretically?

The full text mentions masks being particularly effective and inhaled antiviral meds that could slow the spread of the virus in airways. It also talks about the need for antiviral agents capable of crossing the brain-blood barrier. See the last 3 paragraphs of the full text.

Re: The neuroinvasive potential of SARS-CoV2

#27

Post by testplzignore »

newsbinator wrote: post #4

If it did turn out this virus is neuroinvasive and that is what causes acute respiratory problems, how would this be prevented/mitigated/treated, theoretically?

This may sound very stupid, but...

As a sort of "vaccine", would it make sense to have people intentionally infected orally so they build up antibodies before it has a chance to spread to their brain?

Re: The neuroinvasive potential of SARS-CoV2

#29

Post by [deleted] »

bluGill wrote: post #17
morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?

[deleted]
Post reply on HN