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Compass Pathways has set itself up to be the first legal provider of psilocybin

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Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#101

Post by perfmode »

basseq wrote: post #87
perfmode wrote: post #68

Earlier quoted context omitted.

Believe it or not, some people just want to make the world a better place. Profit motive _can_ help to motivate people if there is a lack of motivation. However, it is not true that there _must_ be profit motive. Right now, there is no lack of motivation to get this stuff out there. It is the questionable government prohibition that is holding things back.

The experts/critics seem to be questioning that motivation. They're implying that profit-motive (regardless of any other motive) is inherently bad.

Can you cite an instance of this?

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#102

Post by toufiqbarhamov »

Y_Y wrote: post #60
basseq wrote: post #35

This is an interesting article for HN. It's spun as a negative, using terms like "threatening", "monopoly", "controversial", and "retribution". You could write it the other way, where an immigrant-founded[1] startup is disrupting the mental health industry. Frankly, most of this seems like par for the course. Of course the company is seeking to push their product to market and commercial viability--and the potential…

When will there be an ANN to remove spin and motivated reasoning? It's becoming so tiresome to filter it. Maybe people should try hard to write a factual and forthright account of what they're talking about and then have a note at the end saying "I'm a granola-faith healer, and I think the above is a good idea" or "I'm an old-school conservative lung surgeon, and I hope that you too conclude that this is bullshit".

The ANN will have bias because it won’t have sprung into existence de novo, but will have been programmed and deployed by humans.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#103

Post by dannyw »

ada1981 wrote: post #64
atomical wrote: post #62

Earlier quoted context omitted.

There has to be a profit motive to get something to market. There have been 18 years of small studies on Ketamine for TRD with little progress.

Unless you look at the other psychedelic with breakthrough status - MDMA, which Rick Doblin has brought through clinical trials as a non-profit. Doblin has no profit motive and is stoked with his $70k a year salary. His goal is changing culture, that is his motive.

MAPS’ MDMA is also commercialised by a for profit company.

As far as I know, the company is independent and not the Mozilla approach (Mozilla Foundstion owns Mozilla corporation).

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#104

Post by bdamm »

ada1981 wrote: post #93
bdamm wrote: post #83

Earlier quoted context omitted.

Unclear. I have close family that is having marked and unprecedented success in treating serious depression by microdosing psilocybin below the psychedelic threshold. The result is profound, sustained, and after trying a dozen different approved psychiatrist prescribed drugs to find help can not be a placebo effect as surely any of those would have been just as effective.

Out of curiosity, have they tried macro-dosing to be ineffective? Ie instead of ongoing microdosing, having a 2-3g experience once or twice. I have very little faith in main stream psychiatric care to provide anything other than blunt palliative options (often with lethal conseuences).

They have not yet, because we haven't found a way to provide a safe environment for this person to be in that can be sustained long enough to cover the entire experience. Providing safety would include alleviating their responsibilities, which includes child care, so that gets pretty complex.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#105

Post by pbhjpbhj »

ogoldhill wrote: post #41
waynecochran wrote: post #13

Earlier quoted context omitted.

What are the downsides of legalizing Psilocybin and/or using it for treating depression?

At the moment, there's nowhere near enough research yet to know the potential downsides of using psilocybin to treat depression. So far, there's only been one study with 19 participants and no control group. It could be hugely successful or, as with any drug, it could come with possible side effects.

Only one study on psilocybin? Globally? Ever? That's kinda amazing; not even studies in v long-term [mental] health of [former] users?

Edit: Google Scholar shows hundreds of studies, one on the first page (for me) has >700 citations.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#106

Post by rdiddly »

basseq wrote: post #35

This is an interesting article for HN. It's spun as a negative, using terms like "threatening", "monopoly", "controversial", and "retribution". You could write it the other way, where an immigrant-founded[1] startup is disrupting the mental health industry. Frankly, most of this seems like par for the course. Of course the company is seeking to push their product to market and commercial viability--and the potential…

You can spin it any way you want, but to me, expropriating the intellectual property of the non-profit (obtained under the pretense of being a non-profit) and exploiting it for private gain is the issue here. Even though that part is apparently legal. (Unless challenged in court somehow. We'll see.)

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#107

Post by alexibm »

basseq wrote: post #35

This is an interesting article for HN. It's spun as a negative, using terms like "threatening", "monopoly", "controversial", and "retribution". You could write it the other way, where an immigrant-founded[1] startup is disrupting the mental health industry. Frankly, most of this seems like par for the course. Of course the company is seeking to push their product to market and commercial viability--and the potential…

I'm so tired of comments like "startup is disrupting the [xyz] industry." No they don't disrupting anything. They didn't invent anything. They are just planning to grow and sell mushrooms. Growing mushrooms is well know process.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#108

Post by nopacience »

It is illegal to prohibit oneself from harming oneself.

This is why drug use will be allowed sooner or later. It has been prohibited and it is inconstitutional.

Unfortunately, many people have been arrested for harming themselfs only and not harming others.

If drugged person hurts someone else, then that is a crime. But using any type of substance to hurt oneself is not a crime.

All the bans will eventually be unbanned.

Its inconstitutional.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#110

Post by achileas »

ada1981 wrote: post #95
johnwyles wrote: post #71

Earlier quoted context omitted.

I'm not saying you're wrong per se but what evidence do you have that there are no beneficial analogs and triggers for similar biochemical pathways that perhaps are not marked by a substantial or profound classically psychedelic experience?

My understanding is that much of mental illness is caused by unprocessed trauma and the way in which we process trauma is in altered states. This is why various pathways like ayahuasca, mushrooms, LSD, mdma, Holotropic Breathwork, EDMR etc all work from vary different pathways — they all enduce an altered state, in which the nervous system releases the experience and forms new pathways.

Many of those (specifically ayahuasca, psilocybin, and LSD) all work on very similar pathways and structures. MDMA works on different ones and produces are markedly different experience and isn't usually considered a psychedelic.
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