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Compass Pathways has set itself up to be the first legal provider of psilocybin

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Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#91
post #76

Earlier quoted context omitted.

I'm not saying you're wrong per se but what evidence do you have that there are no beneficial analogs and triggers for similar biochemical pathways that perhaps are not marked by a substantial or profound classically psychedelic experience?

It's much harder to prove a negative. What evidence do you have that there are? If you consider the way these drugs must be administered to be effective - with a co requisite therapy session - it seems obvious that the conscious effects are the beneficial ones.

There is sufficient evidence for both, and there is probably good reason to split them out (body and mind) and see them as different things that also work combined (body + mind). In this you might compare something like kambo to ayahuasca and ibogaine. They have many similar effects but have different ways of getting there (some more physical some more spiritual ,Kambo is probably not going to help with your childhood abuse, but it may help your high blood pressure, ayahuasca may help you process your childhood abuse and as a result lower your blood pressure.) If you look at something like 2cb vs lsd, lsd is found to be considerably more productive/creative than 2cb at subthreshold doses, but people often experience a much better "therapy trip" on high dose 2cb.

Some great books are:

The Psychedelic Explorer's Guide- James Fadiman

Acid Test - LSD, Ecstasy, and the Power to Heal - Tom Shroder

Sacred Knowledge - Psychedelics and Religious Experiences - William Richards

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#92

Earlier quoted context omitted.

> People should be allowed to harm themselves if they want to As long as they pay for their own medical insurance.

This attitude is the one thing that keeps me from embracing universal government-provided health insurance. People are so quick to use it as a justification for legal restrictions on behavior.

I wouldn't let someone's knucklehead comment dissuade you from supporting something that would do a huge amount of good for people here in America.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#93
post #83
post #66

Earlier quoted context omitted.

What people seem to miss is that it’s the psychedelic experience itself that holds the healing potential. We most likely won’t see a pill derived from mushrooms that cures depression but doesn’t get you high. The altered state of conciousness is the thing.

Unclear. I have close family that is having marked and unprecedented success in treating serious depression by microdosing psilocybin below the psychedelic threshold. The result is profound, sustained, and after trying a dozen different approved psychiatrist prescribed drugs to find help can not be a placebo effect as surely any of those would have been just as effective.

Out of curiosity, have they tried macro-dosing to be ineffective?

Ie instead of ongoing microdosing, having a 2-3g experience once or twice.

I have very little faith in main stream psychiatric care to provide anything other than blunt palliative options (often with lethal conseuences).

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#94
post #81

Earlier quoted context omitted.

did you read the article completely? there are 9 critics that worked with them, 6 ceased doing so. the company formed and closed it's non-profit venture and they are using typical pharma tactics, creating patents around it. spin is one thing but those facts do tell a story on it's own. > These experts are further troubled by the company’s business structure: Having first registered as a charity, Goldsmith and Malievs…

Yes, I did. To me, there's an undercurrent here that some of the psychedelic experts have specific, subjective viewpoints (à la Richard Stallman). That these people have concerns is interesting , but the case that they're material or even right wasn't proven. Again, no surprise that they shuttered the nonprofit: it's a corporate structure that precludes you from raising traditional VC, among other limitations. And si…

I think you're purposefully ignoring the other issues that the writer has illustrated quite well in the article.

I was going to spend time citing points but you should be well aware of them by this point and I'd rather get back to work.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#95
post #66

Earlier quoted context omitted.

What people seem to miss is that it’s the psychedelic experience itself that holds the healing potential. We most likely won’t see a pill derived from mushrooms that cures depression but doesn’t get you high. The altered state of conciousness is the thing.

I'm not saying you're wrong per se but what evidence do you have that there are no beneficial analogs and triggers for similar biochemical pathways that perhaps are not marked by a substantial or profound classically psychedelic experience?

My understanding is that much of mental illness is caused by unprocessed trauma and the way in which we process trauma is in altered states.

This is why various pathways like ayahuasca, mushrooms, LSD, mdma, Holotropic Breathwork, EDMR etc all work from vary different pathways — they all enduce an altered state, in which the nervous system releases the experience and forms new pathways.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#97

Earlier quoted context omitted.

> People should be allowed to harm themselves if they want to As long as they pay for their own medical insurance.

This attitude is the one thing that keeps me from embracing universal government-provided health insurance. People are so quick to use it as a justification for legal restrictions on behavior.

[deleted]

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#98

This is a natural product. One can grow it in the basement of one's home. One can gather it where it grows wild. (Ask me how I know!) No user of this product has ever harmed anyone else as a result of using it. Any restrictions at all on this product could only ever be tyrannical. Let's not abide tyranny, ok?

I really don't know much about it beyond the anecdotes I've heard from friends and others, but aren't there cases of psychotic behavior (going berserk) and also suicide? BTW, I wouldn't use the term "natural" as an indicator of how benign it is -- the following are also natural: arsenic, anthrax, mercury, water hemlock, and castor beans.

Not to mention Amanita Ocreata or A. Phalloides.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#99
post #29
post #2

if they're trying to monopolize psilocybin, they probably should have chosen something that isn't replicable by a teenager with access to a pressure cooker and a pasture

You mean pressure cooker and closet.

where i’m from the mushrooms grow wild in pastures and one may source spores from them

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#100
post #81

Earlier quoted context omitted.

did you read the article completely? there are 9 critics that worked with them, 6 ceased doing so. the company formed and closed it's non-profit venture and they are using typical pharma tactics, creating patents around it. spin is one thing but those facts do tell a story on it's own. > These experts are further troubled by the company’s business structure: Having first registered as a charity, Goldsmith and Malievs…

Yes, I did. To me, there's an undercurrent here that some of the psychedelic experts have specific, subjective viewpoints (à la Richard Stallman). That these people have concerns is interesting , but the case that they're material or even right wasn't proven. Again, no surprise that they shuttered the nonprofit: it's a corporate structure that precludes you from raising traditional VC, among other limitations. And si…

[deleted]
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