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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#211

Post by Escolte »

zzzcpan wrote: post #200
Escolte wrote: post #198

Earlier quoted context omitted.

I also wonder why for example the Chinese or heck the Cubans didn't discover this before, who have less of a corporate interest. Ibuprofen (And Naproxen, etc...) is one of the most common drugs all around the world. I think most people I know have taken them at least once in their lifetimes. It's just all too weird. Is this all a malignant cover up by the industry? Don't know what to say, especially considering this…

My perception is that in the US ibuprofen is used like candy, while it's not the same in other countries, where, for example, aspirin has that role.

I was prescribed to take Naproxen, another NSAID with potentially the same harmful effects as Ibuprofen, for two weeks three times a day half a dose. I'm from Spain.

But IDK. Let me reiterate that everyone all around the world uses Ibuprofen.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#212

Post by zzzcpan »

Escolte wrote: post #211
zzzcpan wrote: post #200

Earlier quoted context omitted.

My perception is that in the US ibuprofen is used like candy, while it's not the same in other countries, where, for example, aspirin has that role.

I was prescribed to take Naproxen, another NSAID with potentially the same harmful effects as Ibuprofen, for two weeks three times a day half a dose. I'm from Spain. But IDK. Let me reiterate that everyone all around the world uses Ibuprofen.

I'm curious, did you have naproxen/ibuprofen at home before they prescribed it to you? Probably not, but I bet you have aspirin at home.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#213

Post by nnain »

aejnsn wrote: post #35

Just had a kidney stone problem—first for me, quite painful experience. My ibuprofen dosage is 800mg every 8 hours, as needed. I had little choice. “Sustained” is the keyword of the study here. On another note, maybe this will drive alternative treatments such as CBD/marijuana for those who need to sustain their pain relief.

I guess it's ok for emergency/surgery etc. The bigger problem is for people who take it regularly.

A friend used to pop ibuprofen casually after gym sometimes to relieve sore muscles. That's messed up.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#214

Post by brokensegue »

philliphaydon wrote: post #11
azhenley wrote: post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…

why aren't you taking a triptan?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#215

Post by peatmoss »

coldtea wrote: post #172
sergiotapia wrote: post #43

Earlier quoted context omitted.

Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though

You can still give them aspirin and/or ibuprofen. People have done it for over half a century, and the sky hasn't fallen. How much/often were those people taking ibuprofen to have those effects? And how worse were they than the baseline? From what I see, they took 3 times a day for 2-3 weeks (not just to pass a small fever), and they were older men to begin with (e.g. already on a downfall for testosterone).

Except you should avoid aspirin for kids probably:

https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#216

Post by pergadad »

Valmar wrote: post #186
ricardobeat wrote: post #156

Earlier quoted context omitted.

In curious how can they make a statement such as “the study cannot be used to draw any conclusions” without providing any kind of reasoning, and get published in Nature?

Whenever I see blanket statements like this in such studies ~ it's like they're trying to avoid pissing any powerful corporations that profit from whatever we're told to not draw any conclusions about. They don't want to potentially endanger their careers. Drug companies hate it when a cash-cow drug is threatened in any way. Anything that threatens those profits is a potential target in one way or another. Researcher…

Ibuprofen is not really a cash cow though as it is now out of patent protection. So while you seem to desire maliciousness I'd venture to say.this is a rather prudent scientific approach. Should all men stop taking ibuprofen on the basis of this one study? No, obviously not.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#217

Post by sgt101 »

coldtea wrote: post #177
sgt101 wrote: post #120

Earlier quoted context omitted.

Has this happened often? Also, how often do you measure the child's temperature and how do you establish the rapid uptrend?

> how often do you measure the child's temperature As often as you need when they have a fever. Modern thermometers can give you the temperature in a minute or so.

yes, but is this sampling a good idea? Have you tried measuring temperatures periodically when the child appears well? What is the variation then? How do you know that the device is telling you something meaningful? Is the child getting flustered and hotter because of the attention?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#218

Post by just_one_time_ »

gameswithgo wrote: post #168
jey wrote: post #2

"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…

>However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health why not?

Because legal reasons.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#219

Post by philliphaydon »

brokensegue wrote: post #214
philliphaydon wrote: post #11

Earlier quoted context omitted.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…

why aren't you taking a triptan?

When I started getting migraines as a teen the doctor tried Ibuprofen first, but it didn't help at all. He then tried Synflex, this contains naproxen, and it helped.

In NZ / Singapore I have to visit a doctor to get synflex, so I usually just visit the pharmacy while I'm in Taiwan and pick up ~50 or so Naposin pills (generic naproxen) while I'm there. Costs ~$10 usd.

Never needed to go any stronger.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#220

Post by philliphaydon »

donjoe wrote: post #142
philliphaydon wrote: post #11

Earlier quoted context omitted.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…

Just as a side hint: did you ever get your vitamin levels checked? I had migraines with aura a couple of times a week until I got a full vitamine check up on B vitamines and Q10. I had a huge lack of B12 plus Q10. I managed to compensate with supplements (the expensive ones from the pharmacy) and didn't have migraine now in 3 months. Might be worth looking into :)

I haven't. I have a stack of multi vitamins & B12 here so I'll take them and see how I go. Thanks for the info.
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