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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#41

Post by Alex3917 »

Dylan16807 wrote: post #28
Alex3917 wrote: post #20

Earlier quoted context omitted.

> My prescription was 800mg. Sure, but it’s not like 800mg is 4x or even 2x more effective than 200mg. Ibuprofen is great, I just don’t really see the point of risking dying and whatever else for what’s at most a very marginal benefit. It’s not enormous in the sense that it’s uncommon per se, but rather in the sense that it’s way outside the efficient frontier on the risk/reward curve.

> I just don’t really see the point of risking dying and whatever else Ibuprofen is not the painkiller where taking 2x the recommended limit has an enormous risk of death.

Yeah it’s not like acetaminophen where you’re going to immediately die, but if you look up recent papers on NSAID mortality the risk is still a lot higher than previously thought.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#42

Post by tejasmanohar »

acct1771 wrote: post #36
gonyea wrote: post #9

Earlier quoted context omitted.

I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.

And acetaminophen reduces empathy, according to some convincing research. What's wrong with cannabis-derived solutions, again?

What about it reduces empathy? My uneducated guess would be that it's unrelated to _which_ pain medicine you choose.

Also, FWIW, in the past, I tried both CBD and THC without any luck where Ibuprofen helped so it's certainly not 1:1

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#43

Post by sergiotapia »

michaco33 wrote: post #3
jey wrote: post #2

"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

Same just did that.

>resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased.

Fuck that.

I wonder what I should give my kids when they have fevers though

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#47

Post by jjtheblunt »

tejasmanohar wrote: post #40
emersonrsantos wrote: post #31

Ibuprofen induced liver toxiticy: https://livertox.nih.gov/Ibuprofen.htm "Rates of serum aminotransferase elevations during low dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%). However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%)."

This is news to me. The more common side effect I've heard of from regular or excess NSAIDs like Ibuprofen are stomach problems (eg ulcers, gastritis, etc.).

That's a side-effect of inhibiting cyclooxygenase-1, which correlates to mucus production, such as that which protects stomach linings. Ibuprofen is a non-selective "COX"=cyclooxygenase inhibitor so inhibits COX-2, correlated with inflammation, while undesirably also inhibiting COX-1.

This gives rise to the selective COX-2 inhibitors, meant to reduce inflammation with minimal mucus inhibition, such as Celebrex and Firocoxib.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#48

Post by bitL »

scjr wrote: post #34
gonyea wrote: post #9

Earlier quoted context omitted.

I get what you're saying, but ibuprofen and acetaminophen save lives. The problem is the western (American?) tendency to self-medicate and to over medicate with really potent stuff. That shouldn't be as normal as it is.

I am not aware of any common uses of Ibuprofen and Acetominophen that saves lives?

Ibuprofen is anti-inflammatory medication.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#49

Post by Escolte »

philliphaydon wrote: post #11
azhenley wrote: post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…

As someone who's had a permanent migraine since months ago, second on naproxen. Ibuprofen does nothing to relieve my headache, and so far the only drug I've found that's effective against it at least mildly is naproxen.

Don't take it every day though. Maybe once a month if I feel like the headache hurts me more than usual.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#50

Post by docbrown »

bitL wrote: post #48
scjr wrote: post #34

Earlier quoted context omitted.

I am not aware of any common uses of Ibuprofen and Acetominophen that saves lives?

Ibuprofen is anti-inflammatory medication.

>Ibuprofen is anti-inflammatory medication.

And an acetaminophen tablet is a painkiller. While your statement is in fact true, ibuprofen is still a better choice for a fever. The latter is also generally considered a safer alternative, especially in long-term use — even though alternating the two would be ideal.

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