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"... prescription medication..."
Ah, good catch, I didn't notice that part. Here's a more relevant link, evidence for the trade-offs of OTC painkillers: https://www.sciencedirect.com/science/article/pii/S014067360... . Seems there's evidence of a link between use of paracetamol in early childhood and developing asthma.
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Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.
Same just did that. >resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Fuck that. I wonder what I should give my kids when they have fevers though
How much/often were those people taking ibuprofen to have those effects? And how worse were they than the baseline? From what I see, they took 3 times a day for 2-3 weeks (not just to pass a small fever), and they were older men to begin with (e.g. already on a downfall for testosterone).
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Please note that acetaminophen/paracetamol is incredibly safe at normal doses and does not kill your liver. It is only when you attempt to overdose (or if you have severely limited liver function) that you run out of the liver enzymes that break it down, causing liver damage.
At normal doses, Acetaminophen can trigger Stevens-Johnson Syndrome and toxic epidermal necrolysis. You're lucky if you wind up with rashes as opposed to skin falling off.
Probably not:
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My guess is the down vote comes from someone thinking your comment sounds like you don't have any children or know what you are talking about. You don't give ibuprofen for pain during a fever, though doctors will say it can help because often times the source of the fever will cause pain like an ear infection or strep throat, you give it to reduce the temperature. There is a serious risk of seizure in children if you…
Why do you not help your kids when they are in pain?! This is truly shocking to me, it is definitely a cruel and inhumane sentiment.
Do you give your children general anesthesia when they are in pain? E.g. they've fallen and bummed their knee or something?
Why not, since it would be the ultimate pain-killer? Because it's both dangerous and unnecessary.
The parent has the same reasoning for other unneeded and dangerous drugs.
Why can discuss whether they're really as unneeded and dangerous as the author implies, but that's another question, not loaded with "why don't you love your children" implications...
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Painkillers are not side effect free; if the pain is something minor, like a bruised knee or normal headache, it's not unreasonable to decide that experiencing the pain is a better choice than risking the side effects of a drug, which in uncommon cases can be much more severe and long term. It's not as clear cut as "helping" vs not helping, as unfortunately we don't yet have any side effect free painkillers.
You could also teach your kids meditation techniques to be deployed when in pain.
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OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?
No tradeoffs? I don't think such a thing exists. Aspirin kills people every year. The only pain reliever I know of that has never killed anyone is cannabis. I don't think it does much for fever though?
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Rapid rise in temperature in infants, toddlers, and young children can cause febrile seizure. Given the trade-offs, we generally choose to medicate our child when his temperature passes ~102 and it's on a rapid uptrend.
Has this happened often? Also, how often do you measure the child's temperature and how do you establish the rapid uptrend?
As often as you need when they have a fever. Modern thermometers can give you the temperature in a minute or so.
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>I wonder what I should give my kids when they have fevers though You don't have to give them anything. Ibuprofen doesn't make the underlying infection causing the fever go away any quicker, it just alleviates the symptoms. It's a trade off between reducing short-term suffering and risking long-term defects. Personally my parents never gave me painkillers for fever and I'm grateful for it: fever pain is just a tempor…
These kind of sentiments really scare and provokes me. Telling anyone that they shouldn't alleviate kids fever and/or pain is absolutely revolting to me.
Or are you OK with hurting your kids, as long as they don't feel the pain?
(I'm putting the questions in the same tone you put yours)
"Ibuprofen and hypogonadism — bench to bedside to misinterpreted hype?" at https://www.nature.com/articles/nrurol.2018.26 : > A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on ma…
In curious how can they make a statement such as “the study cannot be used to draw any conclusions” without providing any kind of reasoning, and get published in Nature?