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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#131

Post by logicchains »

stolsvik wrote: post #126
14 wrote: post #112

Earlier quoted context omitted.

My guess is the down vote comes from someone thinking your comment sounds like you don't have any children or know what you are talking about. You don't give ibuprofen for pain during a fever, though doctors will say it can help because often times the source of the fever will cause pain like an ear infection or strep throat, you give it to reduce the temperature. There is a serious risk of seizure in children if you…

Why do you not help your kids when they are in pain?! This is truly shocking to me, it is definitely a cruel and inhumane sentiment.

Painkillers are not side effect free; if the pain is something minor, like a bruised knee or normal headache, it's not unreasonable to decide that experiencing the pain is a better choice than risking the side effects of a drug, which in uncommon cases can be much more severe and long term. It's not as clear cut as "helping" vs not helping, as unfortunately we don't yet have any side effect free painkillers.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#132

Post by logicchains »

raverbashing wrote: post #129
logicchains wrote: post #115

Earlier quoted context omitted.

>Fever is the reason people died so much before discovery of antibiotics. I thought bacterial infections were the response were the reason people died before antibiotics. Fever is the body's response to infection, a primitive means of fighting it. If somebody has a serious infection and you give them anti-fever medication but no antibiotics, they're still at serious risk of death even if their fever goes away. Accord…

An NSAID failing to help with a bacterial infection is not surprising

Yep, but if death was due to the combined effects of both bacterial infection and fever, we'd expect to see a reduction in mortality when fever was treated compared to when it was untreated, which the linked study didn't find.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#133

Post by stolsvik »

logicchains wrote: post #130
stolsvik wrote: post #125

Earlier quoted context omitted.

These kind of sentiments really scare and provokes me. Telling anyone that they shouldn't alleviate kids fever and/or pain is absolutely revolting to me.

I didn't say that, I said it's a trade-off. Taking them reduces pain and the risk of certain complications, but increases the risk of other complications (side effects). According to https://www.consumerreports.org/prescription-drugs/too-many-... , "The amount of harm stemming from inappropriate prescription medication is staggering. Almost 1.3 million people went to U.S. emergency rooms due to adverse drug effects i…

"...prescription medication..."

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#134

Post by tchaffee »

drb91 wrote: post #71
michaco33 wrote: post #3

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

No tradeoffs? I don't think such a thing exists. Aspirin kills people every year. The only pain reliever I know of that has never killed anyone is cannabis. I don't think it does much for fever though?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#135

Post by tchaffee »

eikenberry wrote: post #19

So back to good old aspirin? Acetaminophen slowly kills your liver and Ibuprofen messes with testosterone production.

Aspirin kills people too. Usually from stomach bleeding. If it's pain you're trying to reduce the only one I know of that has never killed anyone is cannabis.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#136

Post by fuzzfactor »

couradical wrote: post #14
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

How is that an enormous dose? The recommendation is 2x200mg every 4-6h. When doing competitive athletics, I probably took 1-3g of “vitamin I” a day. 600mg a day is barely above a single dose.

>How is that an enormous dose?

600mg is over half a gram of pure active ingredient.

Namely isobutylphenylpropionic acid, a cheap commodity product.

This material is not non-toxic and different people will succumb at different levels of lethality to different doses over different periods of time.

Not long ago I lost a friend to liver and kidney failure attributed by her final doctor as due to the 800mg daily recommended by her previous physician over a few year period.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#137

Post by logicchains »

stolsvik wrote: post #133
logicchains wrote: post #130

Earlier quoted context omitted.

I didn't say that, I said it's a trade-off. Taking them reduces pain and the risk of certain complications, but increases the risk of other complications (side effects). According to https://www.consumerreports.org/prescription-drugs/too-many-... , "The amount of harm stemming from inappropriate prescription medication is staggering. Almost 1.3 million people went to U.S. emergency rooms due to adverse drug effects i…

"... prescription medication..."

Ah, good catch, I didn't notice that part. Here's a more relevant link, evidence for the trade-offs of OTC painkillers: https://www.sciencedirect.com/science/article/pii/S014067360... . Seems there's evidence of a link between use of paracetamol in early childhood and developing asthma.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#139

Post by rbjorklin »

My understanding is that Hypogonadism can also affect women. Have a similar study been made on women? I’m under the impression that a lot of women eat painkillers to get through menstrual cramps so this could be a huge problem for women too I guess?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#140

Post by opportune »

arikr wrote: post #81
iandanforth wrote: post #16

Along with the high sustained dosage others have mentioned the small sample size (14 in the experimental group) should be noted.

This is worth reading: The "Unreliable Small-Sample" Misconception https://www.dailykos.com/stories/2008/11/9/656465/- > My point here is that arguing that the sample is inaccurate simply because of how large or small it is is not correct. The size of the sample actually makes very little difference in how applicable the results are to the population. It simply makes the range of possible results smaller as the size…

Small sample size makes publication bias much more likely as well
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