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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

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41–50 of 394 posts

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#41
post #15

Earlier quoted context omitted.

Beautiful yet terrifying. I'm glad that regex isn't something I'll ever have to touch.

It's not that bad. AutoRegex[0] and regex gen [1] make it more accessible than ever. [0]: https://www.autoregex.xyz/ [1]: https://regex-generator.olafneumann.org

Heh, I just fed autoregex a regex from one of my projects, and it simply times out. It comforts me to know that billion dollar LLMs have to chew on those just as much as I do.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#42

Is the muscle loss a side effect of the drug or of the weight loss?

Lean mass is just non-fat mass. That includes much more than just muscle.

I can't find any evidence that GLP-1 are catabolic to muscle mass. There is no evidence I can find that GLP-1s do anything above what calorie restriction does.

There is a linear relationship between calorie restriction and fat loss down to under 10% body fat. There is so much wrong information on calorie restriction from studies done on people who were literally starving with already very low body fat %. Then apply that to people with 25% body fat is just wrong.

Westerners trying to lose weight don't have this problem. I think part of the obesity epidemic is this insane idea that calorie restriction is bad. Everyone kind of understands the thermodynamics of calories in / calories out. Everyone even kind of understands the benefits of fasting. At the same time though there is this nonsense that if you restrict calories too much you start burning all this muscle mass. It is patently absurd.

Add up the calories of what a 250lb bodybuilder is eating for contest prep to lose fat and you will see they are "starving" too.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#43
post #26

Earlier quoted context omitted.

Isn’t everything naturally occurring? It all originates from earth, where else would it come from?

They did specify "molecule". Certainly not every pharmaceutical occurs naturally, and other materials such as Teflon don't either.

We're part of nature and so everything we do is occurring there. Is the real distinction things that wouldn't exist without human intervention? So, like Teflon and plumcots wouldn't be natural but water and plutonium are.

Things that aren't naturally occurring would be supernatural, no?

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#45
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

[flagged]

my grandma always said her knee hurts when it's about to rain

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#46
post #2

What does "naturally occurring" mean in this context?

I would say that the prohormone BPM/retinoic which BRP is derived from occurs in the body and is therefore natural. If it would be a derivate of BRP chemically similar patentable then it would not be natural. Even if BRP is made in the lab it’s still natural. AFAIK one can’t patent natural occurring molecules, only the process to make them.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#47
post #26

Earlier quoted context omitted.

Isn’t everything naturally occurring? It all originates from earth, where else would it come from?

Some elements don’t occur naturally and need to be formed artificially / by force by smashing together atoms that would never smash together in nature (in some cases because those atoms in turn also don’t exist in nature).

I suspect chasd00 is making a pedantic point that the atoms are smashing together in nature. Because nature is just everything that happens.

Although pedantic, it does challenge what we really mean when we say "natural". Just like what we mean when we say "chemicals". Everything is chemicals.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#48
post #40

Earlier quoted context omitted.

[flagged]

I’m not sure what this brings to the conversation. Are you able to attest to the correctness of what Sonnet claims?

I think we can be chill about it. For someone on the sidelines, mildly interested in the topic, an AI summary of the regex might be useful — and the person getting downvotes is saving some of us the time.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#50

Is the muscle loss a side effect of the drug or of the weight loss?

The drug does not directly affect muscle mass (unless you are already very lean), but heavy people are doing resistance training against their own body weight all the time, so they are strong in the absolute, even if not relatively. Weigh less and your muscles have it easier, so weaken, unless you keep them strong with exercise.
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