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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

medicalxpress.com

21–30 of 394 posts

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#21
post #15
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

Beautiful yet terrifying. I'm glad that regex isn't something I'll ever have to touch.

It's not that bad. AutoRegex[0] and regex gen [1] make it more accessible than ever.

[0]: https://www.autoregex.xyz/

[1]: https://regex-generator.olafneumann.org

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#22
post #4
post #2

What does "naturally occurring" mean in this context?

> Svensson has co-founded a company to launch clinical trials of the molecule in humans in the near future. At least not so natural that just 'anybody' can put it in a bottle.

Having to run trials has little to do with the whether the compound is naturally occurring and everything to do with the fact they intend to market it as a drug with specific effects

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#23
post #6

Earlier quoted context omitted.

The article refers to results in animals which means it is probably years - maybe a decade - from being approved. Novo’s patent protection expires in 2033 [0] so it could be that the market is not yet worried about a potential competitor that likely won’t get to market before the IP protection runs out. [0]: https://www.reddie.co.uk/2024/08/30/the-year-of-ozempic-an-i...

And Novo (like many others) is already working on next-generation GLPs that’ll have new patent protection before Ozempic’s ends.

Even so, competition from other GLP-1 drugs and generic semaglutide should make prices and profits lower.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#25
post #2

What does "naturally occurring" mean in this context?

Most people think "natural" means they can just go into backyard, dig up some root, and get this for free. But its " Gila Monster’s venom". So natural, but you aren't going to just go out and eat it like resveratrol from wine. At this point, 'natural', just means made from atoms, yes atoms are naturally occurring.

See food packaging laws. Natural versus artificial flavorings :)

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#27
post #26
post #5

Isn't the molecule in Ozempic naturally occurring too?

Isn’t everything naturally occurring? It all originates from earth, where else would it come from?

Solar power isn’t naturally occurring, originates from outside of earth.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#28

They mention AI used to weed out molecules but don't mention how it was used. I'd be interested in know did they use pre-trained models or train one from the ground up.

https://www.sciencealert.com/ai-experiment-generated-40-000-...

For another example, and it actually calls out the name of the program.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#29
post #26

Earlier quoted context omitted.

Isn’t everything naturally occurring? It all originates from earth, where else would it come from?

Solar power isn’t naturally occurring, originates from outside of earth.

It is naturally occurring though.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#30
post #8
post #4

Earlier quoted context omitted.

> Svensson has co-founded a company to launch clinical trials of the molecule in humans in the near future. At least not so natural that just 'anybody' can put it in a bottle.

I think this is not really a charitable take. For one, nearly everything medical needs certain purity and concentration so you need specialized equipment. For two, even if a chemical is easy to produce by industrial standards, you still need to run trials to prove that it's both safe and actually does what you hope it does.

I wonder what the distinction here is between supplement and pharmaceutical.

Could they have chosen to bring it to market as a supplement?

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