Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

Post by llamaimperative » Fri, Mar 07, 2025, 12:10 PM UTC

docdeek wrote: post #6

tromp wrote: post #3

If this really has the potential to compete with Ozempic, then it should have a noticeable impact on Novo Nordisk's stock value [1], but we're not seeing that yet. [1] https://finance.yahoo.com/quote/NVO/

The article refers to results in animals which means it is probably years - maybe a decade - from being approved. Novo’s patent protection expires in 2033 [0] so it could be that the market is not yet worried about a potential competitor that likely won’t get to market before the IP protection runs out. [0]: https://www.reddie.co.uk/2024/08/30/the-year-of-ozempic-an-i...

Post by chpatrick » Fri, Mar 07, 2025, 12:24 PM UTC

llamaimperative wrote: post #11

chpatrick wrote: post #9

Earlier quoted context omitted.

As far as I know GLP-1 is a naturally occurring hormone but it's not something you can just give people directly. Instead you give them artificial things like semaglutide that work on the same receptors.

GLP-1 is a class of drugs (or molecules). The first known GLP-1 was pretty much just a synthesized version of a naturally occurring compound from the Gila Monster’s venom. Semaglutide is like a 2nd generation GLP-1 and there are 3rd generation ones in development right now

Post by llamaimperative » Fri, Mar 07, 2025, 12:28 PM UTC

chpatrick wrote: post #14

llamaimperative wrote: post #11

Earlier quoted context omitted.

GLP-1 is a class of drugs (or molecules). The first known GLP-1 was pretty much just a synthesized version of a naturally occurring compound from the Gila Monster’s venom. Semaglutide is like a 2nd generation GLP-1 and there are 3rd generation ones in development right now

Semaglutide and co are "GLP-1 receptor agonists" that behave in a similar way to the naturally occurring hormone GLP-1. We can't give people GLP-1 itself because it breaks down really fast and you'd have to provide it continuously, so we use ones that effect the body the same way over a long period of time.

Post by Clubber » Fri, Mar 07, 2025, 12:33 PM UTC

FrustratedMonky wrote: post #13

cj wrote: post #2

What does "naturally occurring" mean in this context?

Most people think "natural" means they can just go into backyard, dig up some root, and get this for free. But its " Gila Monster’s venom". So natural, but you aren't going to just go out and eat it like resveratrol from wine. At this point, 'natural', just means made from atoms, yes atoms are naturally occurring.

Post by jagged-chisel » Fri, Mar 07, 2025, 12:46 PM UTC

mkoubaa wrote: post #15

thom wrote: post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

Beautiful yet terrifying. I'm glad that regex isn't something I'll ever have to touch.