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GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#121

Post by [deleted] »

tssva wrote: post #109
xtracto wrote: post #96

Earlier quoted context omitted.

Several members of my family are into glp-1 both for glucose control and for weight loss. Taking different brands (wegovy, ozempic and others.) They all mention.th terrible secondary effects when you eat something "forbidden" (tacos, cake or icecream e.g.) . Also It causes constipation apparently, which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.

I take a glp-1 and suffer no ill effects when I eat something "forbidden".

[deleted]

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#122

Post by CobrastanJorji »

WillPostForFood wrote: post #114
cess11 wrote: post #103

Earlier quoted context omitted.

No, it is not. They said that since someone, which is typically a fictive person, had spent a lot of money, they deserve to restrict physical persons' access to supposedly life saving substances. I would like to know how far they take that position.

How many people do you feel liek you are personally responsible for killing because you haven't given 100% of your disposal income to food relief? Hundreds? Thousands?

This isn't "I could use my money to acquire food for the poor." It's "I'm going to prevent anyone else from selling food, and that will let me charge 100x as much for food."

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#124

Post by CalRobert »

unsupp0rted wrote: post #23
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Not everything has another shoe to drop. Getting people to eat more broccoli is almost entirely upside. Sure a handful of people will be allergic or whatever, but on a population level some interventions are just one positive after another, and there's no reason it has to be a deal made with the devil.

I do get a bit gassy if I binge on broccoli…

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#125

Post by icebergonfire »

tssva wrote: post #109
xtracto wrote: post #96

Earlier quoted context omitted.

Several members of my family are into glp-1 both for glucose control and for weight loss. Taking different brands (wegovy, ozempic and others.) They all mention.th terrible secondary effects when you eat something "forbidden" (tacos, cake or icecream e.g.) . Also It causes constipation apparently, which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.

I take a glp-1 and suffer no ill effects when I eat something "forbidden".

More anecdata, my spouse and I have been on Mounjaro since Jan 2025 guided by private health insurance.

I have suffered almost the entire gamut of side effects from the beginning until I tried split dosing twice a week, and even then there’s still the occasional instance of me learning that I should not have eaten that and the following 9 hours are going to revolve around stomach pain.

My partner’s journey on the other hand has been smooth sailing the entire time.

YMMV, do your own research but definitely double check any search results with your doctor first… lots of urban myths going around.

I do recommend it though, I am the healthiest I’ve been in literally 10 years.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#126

Post by chrisco255 »

thefz wrote: post #108
toomuchtodo wrote: post #40

Earlier quoted context omitted.

Many Americans drive a car every day, even though ~40k people a year die in car accidents. Why? Because the benefits outweigh the risk. (my partner is on a GLP-1, and lost ~25 lbs in 3 months)

> Many Americans drive a car every da Coincidentally also a factor of why many Americans take GLP-1 frugs

Not really, Americans have been driving cars for over 100 years but the obesity epidemic cropped up in the last 30 years.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#127

Post by icebergonfire »

andy_ppp wrote: post #76
pedalpete wrote: post #65

Earlier quoted context omitted.

My understanding is that it slows the digestive process, so there isn't more "empty time to repair or relax". But my thinking there may be naive.

I just know someone who skips breakfast and lunch on the jabs… maybe he eats dinner I’ve not checked.

Anecdotally speaking I can confirm this… it gets easy to just skip a meal, and you may end up skipping the entire day because the usual hunger signals are just not there.

For anyone tempted by that concept, please don’t and remember to try to eat your 1000-1500 calories every day.

Quick weight loss won’t do you any good if you lose all your muscle mass, or if you carve a deeper groove into body image issues.

It’s cliche but it’s true, slow and steady is the way to go.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#128

Post by Cthulhu_ »

cyrusradfar wrote: post #81
jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

I for one don't "require" three meals a day, but I'm hungry in the morning, ergo, I like breakfast.

It's not so much about how often you eat but what and how much. Generally speaking, of course, I can't speak for any benefits of intermittent fasting (assuming equal daily calorie / macronutrient intake) because I'm uneducated in that regard. But TL;DR, I will agree that desk jockeys will need less calories than people with a more active job or lifestyle, and people need to adjust their lifestyle accordingly else they'll gain weight.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#129

Post by InMice »

cyrusradfar wrote: post #81
jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

ALmost everyone who shares their positive, any length fasting experience here gets downvoted. I will always upvote them. Ive done two 48 hour fasts and they were so relaxing and felt so natural. It just feels great to occasionally go about your day and not eat anything. Your gut tries to heal itself in between meals. The fact that almost all of HN just cant stand anyone mention they fast with positive benefits (and mounting evidence) is kidna sad. I guess every community has to be exceptionally closed minded about something.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#130

Post by Cthulhu_ »

hexbin010 wrote: post #112
surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Same here. There's less wanting it but also, if I do indulge even one small glass of wine, the side effects are awful: broken sleep, acid reflux and a hangover the next day. It really slaps you in the face for indulging

Harsher side-effects to drinking sounds like an effective deterrent (although you'd think people would quit after that one hangover they'll never forget). Works for me with candy, a lot of it gives me tooth pain. My teeth are otherwise healthy, no cavities or anything.
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