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GLP-1 drugs linked to lower death rates in colon cancer patients

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#101

Post by viking123 »

radial_symmetry wrote: post #16
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. My personal theory (based on nothing but my own intuition) is that GLP-1s are an adaptation to the modern world that evolution hasn't caught up with yet.

lol

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#102

Post by phil21 »

JumpCrisscross wrote: post #82
zemvpferreira wrote: post #72

Earlier quoted context omitted.

GLP-1’s should make you less concerned in that case, they’re poised to become extremely affordable very soon. Ending the obesity epidemic will do more to bridge the class divide than anything I can practically imagine. Not to mention the other compulsions these drugs help moderate - alcohol, tobacco, gambling etc. It’s my best hope for worldwide quality of life improvement in the next 10 years.

> Ending the obesity epidemic will do more to bridge the class divide My hope is the "waiting for the other shoe to drop" folks are just expressing sour grapes. If it runs deeper and merges with the anti-vaxers, we've got a behavioural problem fuelling a class divide. That is my fear.

I’ve thought about this a decent amount.

My opinion has shifted over the years. At first I also thought it was largely just sour grapes re: accessibility and fear of the unknown, but now I’m thinking that a large number of people are going to be so far deep into anti-GLP opinions and hot takes they can’t backtrack out of it. Much like political or social beliefs you make into your identity. Too embarrassing to admit you might be wrong.

I know you’re alluding to the same thing, it’s just interesting to me someone else in the world seems to share these thoughts. I also think it may really delineate a multi-generational class divide that is hard to break.

Or all the folks on GLP-1s will develop some rare form of cancer and die early leaving the world to the so-called haters.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#103

Post by cess11 »

exabrial wrote: post #80
cess11 wrote: post #64

Earlier quoted context omitted.

Kind of weird to assume other people think it's fine to exchange human lives for money. Is it ethical for me to pay someone to murder you? Does it matter if it costs me a large amount of money or not?

This is a great example of a straw-man attack.

No, it is not. They said that since someone, which is typically a fictive person, had spent a lot of money, they deserve to restrict physical persons' access to supposedly life saving substances.

I would like to know how far they take that position.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#104

Post by culi »

toomuchtodo wrote: post #40
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Many Americans drive a car every day, even though ~40k people a year die in car accidents. Why? Because the benefits outweigh the risk. (my partner is on a GLP-1, and lost ~25 lbs in 3 months)

> Why? Because the benefits outweigh the risk

Many of us wish we didn't have to drive a car. Many of us also wish we didn't live in a world where hyperprocessed foods weren't the norm

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#105

Post by PeaceTed »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

I am sort of in your boat in seeing what may come. There are a few very rare conditions but the benefits seem to out weigh (ha, I will take the pun!) The down sides.

While it might mean the incident rare of some things goes up, those that it reduces are far more impactful and where far more likely to have mortality issues. Sort of like how Chemotherapy is poisonous but potential has better long term odds, only chemo is far more extreme than GPL1.

Time will tell but so far it is looking kind of good with a few lesser issues.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#106

Post by amenhotep »

trallnag wrote: post #94
cyrusradfar wrote: post #81

Earlier quoted context omitted.

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

Awesome insight. It's not the disability I have, it's that I have never tried healing by fasting. Of course. Because my body was always busy trying to eat food instead of fixing and regrowing all the malformed tissue. Because that's how it works. When a person without legs starts to fast, the legs will suddenly develop.

It would be sensible for you to examine and interrogate why reading a general and fairly anodyne opinion about what might be a solution to a problem some people have led you to interpret it as a prescriptive and judgemental suggestion about the specific problem you specifically have.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#107

Post by thefz »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

> Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true.

Well, read up the testimony of those who stopped taking it for adverse effects, such as nonexistent intestinal transit and -yuck- sulfur burps.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#108

Post by thefz »

toomuchtodo wrote: post #40
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Many Americans drive a car every day, even though ~40k people a year die in car accidents. Why? Because the benefits outweigh the risk. (my partner is on a GLP-1, and lost ~25 lbs in 3 months)

> Many Americans drive a car every da

Coincidentally also a factor of why many Americans take GLP-1 frugs

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#109

Post by tssva »

xtracto wrote: post #96
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Several members of my family are into glp-1 both for glucose control and for weight loss. Taking different brands (wegovy, ozempic and others.) They all mention.th terrible secondary effects when you eat something "forbidden" (tacos, cake or icecream e.g.) . Also It causes constipation apparently, which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.

I take a glp-1 and suffer no ill effects when I eat something "forbidden".

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#110

Post by 01100011 »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

I was in that boat too but with NAFLD and now liver fibrosis despite not eating all that much sugar and having a BMI that is high but partially due to muscle I finally gave in to see if semaglutide will help.

Only on week 3 but it's been a rollercoaster. It seems to have quite a broad spectrum of effects. I'm still not sure I'll be able to stay on it but losing 10 pounds is a nice counterpoint to the side-effects.

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