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GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#31

Post by lm28469 »

bitwize wrote: post #3
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Haven't you been reading Hackernews for the past 10 years? Sugar has been implicated in pretty much every major late-life disease, and the closest thing to a cure before GLP-1 agonists was fasting.

That's such a lazy and unimaginative take that basically skips 99.999% of human history during which sugar wasn't a problem at all.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#32

Post by asdff »

exabrial wrote: post #29
isoprophlex wrote: post #26

Earlier quoted context omitted.

"Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.

The laws of thermodynamics apply to everyone equally.

Where in thermodynamic principles does it suggest money ought to flow into the pockets of the few?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#33

Post by azinman2 »

robbomacrae wrote: post #4
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

There have been some. I've heard about eyesight related issues. A quick google found this article [0] where results showed that people using GLP-1 drugs were 68.6 times more likely to develop certain types of vision problems. [0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...

This is also an extremely rare vision problem. So absolute numbers are very tiny. The absolute numbers for diabetes, weight related problems, etc far dwarf this.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#34

Post by cerved »

unsupp0rted wrote: post #23
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Not everything has another shoe to drop. Getting people to eat more broccoli is almost entirely upside. Sure a handful of people will be allergic or whatever, but on a population level some interventions are just one positive after another, and there's no reason it has to be a deal made with the devil.

Well glp1 doesn't make you want to eat broccoli. Just less in general

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#35

Post by jesse_dot_id »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Same. I think that pharmaceutical industry is lot more bleak now than it was when Fen-Phen became popular. GLP-1 usage is largely off-label as far as I know, but I wouldn't trust them even if it wasn't. There is a mountain of precedent for these companies to choose profit over health, and for our government(s) to aid them in covering up evidence of negative effects on the latter for the sake of the former.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#36

Post by pessimizer »

bitwize wrote: post #3
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Haven't you been reading Hackernews for the past 10 years? Sugar has been implicated in pretty much every major late-life disease, and the closest thing to a cure before GLP-1 agonists was fasting.

Hacker News has extreme orthorexia and endorses all sorts of quackery.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#37

Post by phantasmish »

exabrial wrote: post #29
isoprophlex wrote: post #26

Earlier quoted context omitted.

"Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.

The laws of thermodynamics apply to everyone equally.

The standard for medical interventions usually isn’t “could it work?” or “should it work?” but “does it work?”

This is why the efficacy of every single contraceptive method isn’t way higher than it is. Lots of them should work almost perfectly… but the harder they are to use correctly, the less effective they in-fact are.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#38

Post by daedrdev »

cerved wrote: post #34
unsupp0rted wrote: post #23

Earlier quoted context omitted.

Not everything has another shoe to drop. Getting people to eat more broccoli is almost entirely upside. Sure a handful of people will be allergic or whatever, but on a population level some interventions are just one positive after another, and there's no reason it has to be a deal made with the devil.

Well glp1 doesn't make you want to eat broccoli. Just less in general

sure but it definitely makes carbs specifically disgusting in my case

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#39

Post by CyanLite2 »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Its not upside per se, more like avoiding the downsides of diabetes and obesity.

Healthy, non-obese individuals likely aren't seeing these "benefits"... But I'm not a doctor, I just pretend to be one on the Internet.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#40

Post by toomuchtodo »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Many Americans drive a car every day, even though ~40k people a year die in car accidents. Why? Because the benefits outweigh the risk.

(my partner is on a GLP-1, and lost ~25 lbs in 3 months)

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