Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Even with an increased risk of mortality, at least right now I can live. The voice in my head that is constantly telling me I'm hungry is quiet.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Haven't you been reading Hackernews for the past 10 years? Sugar has been implicated in pretty much every major late-life disease, and the closest thing to a cure before GLP-1 agonists was fasting.
… and the mechanism by which GLP-1s cause weight loss is, more or less, by making fasting really easy.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. My personal theory (based on nothing but my own intuition) is that GLP-1s are an adaptation to the modern world that evolution hasn't caught up with yet.
is there an extract or can you get it from natural food? which have it ?
GLP-1 agonists? Well they derived them from a lizard, so, uh… sort of? But no, no foods you eat are really going to have GLP-1 agonists in them, not to any meaningful degree anyway. Plus if you’re eating them they have to survive at least part of the digestive tract, which means you need even more since some of it’ll be lost.
Your body produces GLP-1, but it lives in the blood for like minutes. The innovation was finding a chemical that tickles the same receptors but survives in the body for days at a time.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
At this point I view the risks/downsides as akin to vaccines. Sure things happen, the overwhelming positives greatly outweigh this.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. My personal theory (based on nothing but my own intuition) is that GLP-1s are an adaptation to the modern world that evolution hasn't caught up with yet.
And we know what the adaptation is: calorie constraint. We evolved in a calorie constrained environment. We don't live in one now. Our set point for desire to eat is clearly too high. None of this means that glp-1 inhibitors don't have other side effects, of course.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
There have been some. I've heard about eyesight related issues. A quick google found this article [0] where results showed that people using GLP-1 drugs were 68.6 times more likely to develop certain types of vision problems. [0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...
A lot of the issues are hydration-related, and I wouldn’t be surprised if the eye ones are, too. Some water intake is from food, so if you eat less, you need to drink more. If you also tend to drink with food, and you’re eating less, you may drink less instead of the more that you need to be. Add in a generally dulled “I crave something” sense and you’ve got a recipe for not just going all day without eating, but also without drinking.