Live data from Hacker News

GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

21–30 of 211 posts

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#21
post #15

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine.

It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#22
> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health

Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong null hypothesis because we know that losing weight can have huge and wide-ranging health benefits.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#23
post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Not everything has another shoe to drop.

Getting people to eat more broccoli is almost entirely upside. Sure a handful of people will be allergic or whatever, but on a population level some interventions are just one positive after another, and there's no reason it has to be a deal made with the devil.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#24
post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. My personal theory (based on nothing but my own intuition) is that GLP-1s are an adaptation to the modern world that evolution hasn't caught up with yet.

> Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution.

That's not what evolution is, at all

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#25

is there an extract or can you get it from natural food? which have it ?

There may be some herbal supplements that impact GLP-1 release to some extent, but what is being talked about here are synthetic GLP-1 receptor agonists.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#26
post #15

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

"Sorry bro gonna let you die because, muh investments, you see"

Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#27
post #15

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells.

https://www.sciencedirect.com/science/article/pii/S221112471...

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#29

Earlier quoted context omitted.

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

"Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.

The laws of thermodynamics apply to everyone equally.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#30
post #15

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

The public also invested a lot of money.
Post reply on HN