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Anti-ageing compound set for human trials after turning clock back for mice

theguardian.com

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Re: Anti-ageing compound set for human trials after turning clock back for mice

#21

Post by maratd »

fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo?

Sure. It's ridiculously selfish.

As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of experience? Not exactly fair to those actually 20 years old.

EDIT: To the old farts responding below me, regardless of how well you take care of yourself, you wither with age. By removing that, you are messing with the balance that has existed for millions of years. It has nothing to do with fair competition, it has everything to do with using technology to get ahead of the competition, in the same way that some athletes use performance enhancing drugs, and we as a society frown on that too.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#22

Post by 11001 »

jaibot wrote: post #13
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

Yes. http://dresdencodak.com/2009/09/22/caveman-science-fiction/

Actually, before we started to "poop in the hole", the rates of infectious diseases were way lower.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#23

Post by salient »

ams6110 wrote: post #17
salient wrote: post #12

Earlier quoted context omitted.

I'd rather have the choice. I have no choice with ageing. The same is true of "immortality". What immortality really means is that you kind of have a choice of not disappearing forever (well unless a car runs you down or something, but in the future that can probably be fixed, too, by "backing ourselves up").

Rather selfish? We'll have enough problems in the coming decades with geriatric baby boomers, you now want to give people the option to live forever?

No. Survival is our strongest instinct. Besides, human population will plateau around 10 billion or so, and we're already seeing trends, from very early ones to pretty advanced ones (Japan), where people decide not to have kids anymore in modern societies, or even have sex with other humans.

You're thinking immortality would be a problem given the current conditions. But the conditions will be different in the future. The same will be true for food production, which should be vastly more efficient in the future, and enough to feed everyone.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#24

Post by BadassFractal »

jarnix wrote: post #19

Great for the mice. I don't understand this phrase "Turner said a “magic pill” that reverses ageing is several years away, partially due to the cost of the compound, which would be about $50,000 a day for a human." ? $50,000 a day for a human ? What is the effect of a day of treatment ?

50k at first, 5 bucks eventually, hopefully.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#25

Post by kolev »

mrfusion wrote: post #14
codex wrote: post #6

Can anyone explain how this compound differs from the NAD you can buy as a supplement, if at all?

Well I do see this quote: "Turner said a “magic pill” that reverses ageing is several years away, partially due to the cost of the compound, which would be about $50,000 a day for a human." So in guessing there's some special processing of the compound or a special way to get it into each cell somehow.

Currently, you can buy NADH, which seem different, or NAD+ precursors (Niacin, Niacinamide) or Niagen (https://chromadex.com/Ingredients/NIAGEN.html), which is proprietary and suppoedly increasing NAD+ levels. It's pretty expensive as of now compared to Niacin, but, still, $50/month isn't that much. Combining Niagen with Resveratrol should do the trick.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#27

Post by kps »

ChuckMcM wrote: post #4

I always wonder about this quote, “Whether that means we’ll all live to 150, I don’t know, but the important part is that we don’t spend the last 20 to 30 years of our lives in bad health.” Imagine a process that makes you feel like you are 25 right up until you body gives up at a physical age of 100 or something. Do you end up doing riskier things because you don't "feel" old? And if you did would you die sooner? It…

Personally, I probably do riskier things when I do feel old.

Tick... tick... tick....

Re: Anti-ageing compound set for human trials after turning clock back for mice

#28

Post by moe »

ams6110 wrote: post #17
salient wrote: post #12

Earlier quoted context omitted.

I'd rather have the choice. I have no choice with ageing. The same is true of "immortality". What immortality really means is that you kind of have a choice of not disappearing forever (well unless a car runs you down or something, but in the future that can probably be fixed, too, by "backing ourselves up").

Rather selfish? We'll have enough problems in the coming decades with geriatric baby boomers, you now want to give people the option to live forever?

I have a hunch this is a technology that will take very long to 'trickle down' the forbes list.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#29

Post by johndevor »

maratd wrote: post #21
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

> Now imagine a spry 20 year old with 60 years of experience? Not exactly fair to those actually 20 years old.

How is that "unfair"? You might as well criticize an old person who looks and acts young for taking good care of themselves.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#30

Post by geoffschmidt »

maratd wrote: post #21
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

Hazel thinks George looks exhausted and urges him to lie down and rest his "handicap bag", 47 pounds (21 kg) of weight placed in a bag and locked around George's neck. He says he hardly notices the weight any more. Hazel suggests taking a few of the weights out of the bag, but he says if everyone broke the law, society would return to its old competitive ways. Hazel says she would hate that. A noise interrupts the conversation, and George cannot remember what they were talking about.

http://en.wikipedia.org/wiki/Harrison_Bergeron

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