Earlier quoted context omitted.
Clearly his issue is not understanding its actually all about 'grandma'.
"Think about grandma" was the covid version of "somebody think of the children"
Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
281–290 of 330 posts
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#282Yeah while a positive step, I do not understand a 90% stock increase.
So they added $30B market cap for a drug that would do by my napkin estimate about ~$7B average annual sales for 20 years as a front line treatment. Based on that alone, $30B in added market cap isn't enough. How much would you pay for $150B in high margin revenue? But even more is the validation of this new custom MRNA novel cancer treating platform. If you take this data result to be a 'proof of concept', the expec…
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#283Earlier quoted context omitted.
People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived. Yet Yale-led researchers later detected circulating S1 and full-length spike as late as 709 days after vaccination. They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. That is a massive ga…
> People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived which is still the case, even in the Yale study. > That is a massive gap between what the public was told and what later evidence found. there is an even larger gap between basic epidemiology and what the public understands. Hard science is difficult to communicate on a good day, on a global pandemic with…
What? The Yale study is where the almost two year figure came from. Are you just making things up? Did you read what I wrote, or anything in the study?
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#284Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#285Earlier quoted context omitted.
> There is a legitimate discussion of what can be mandated you do to your body. There is a legitimate discussion (dating back at least to Typhoid Mary (1) ) on excluding people from public spaces when they refuse to take basic public health measures. Taking a vaccine for a spreading deadly pandemic is one of those measures. Doing something so violently anti-social is not simply a "bodily autonomy" issue, and framing…
I got the covid shot and every booster. I have no qualms about mRNA messing me up, and I think it was a tremendous life saver. As stated, there was also a ton of misinformation floating around, and people believed that misinformation. The thing is most of those people made rational objections. The problem is their reasoning was based on false information. They didn't see it as being anti social as they thought the dr…
This is how Typhoid Mary understood her status:
> It did not take Mary long to react to this suggestion. She seized a carving fork and advanced in my direction. ... Mallon's refusal was based on her belief that she was not infected. ... To stop her struggles, he had to sit on her chest for the journey.
And yet, locking her up over her objections her was itself a rational decision. This is the debate.
I'm not saying that this kind of intervention is appropriate today, just that her "rational objections" were not be-all and end-all of the situation.
Why is it more "important to understand why she objected"? Isn't it far more important to understand that she infected? The thing is, a virus doesn't care what you believe, or your political stripe. To a pathogen, you're a mass of warm cells, nothing more. Human beliefs are irrelevant to a virus, so why centre them?
Stopping the spread of e.g. measles depends on vaccinating just about everybody, that's statistics and epidemiology. At the end, that is what determines if there will be an outbreak. Cutting people slack on that because they choose to believe nonsense is not helpful and will not work. Actions matter more than beliefs, voluntary or not.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#286Earlier quoted context omitted.
> People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived which is still the case, even in the Yale study. > That is a massive gap between what the public was told and what later evidence found. there is an even larger gap between basic epidemiology and what the public understands. Hard science is difficult to communicate on a good day, on a global pandemic with…
“Even in the Yale study” What? The Yale study is where the almost two year figure came from. Are you just making things up? Did you read what I wrote, or anything in the study?
yes, the figure that a small sample of people had long period of protein in them. But most people they looked at had none, which was what they expected.
The average time of it was not contested, the long tail was.
My comment was not even that hard to read, makes me wonder what kind of other information you have misread to come to your conclusions
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#287I got my first one at age 27. A third just got removed. Living with the constant mole vigilance of that is rough, but I am glad I've learned to identify them. I think knowing the ABCDEs of it should be more widely spread, as removing a mole is a much nicer alternative to having to take margins in a highly mobile place.
Asymetrical (shape of the mole)
Border (irregular? Unclear delimitation?)
Color (has it multiple colors?)
Diameter (has it a >6mm diameter? An indicator that it might start vertical growth iirc)
Evolution (has it changed recently?)
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#288Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#289This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.
What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#290I wish people would find a decent source for these stories in order to post them on here instead of sending us to a tweet. I'm not on Twitterx and it's a mini nightmare on a mobile browser