Some say that mRNA therapies are getting better and better on a wider range of tumor types, anybody from the industry can confirm ?
Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
181–190 of 330 posts
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#182Earlier quoted context omitted.
> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.
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Who is "they" ? And are they in the room with you now?
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#183Earlier quoted context omitted.
You're misinterpreting data here. You are conflating the fact that the clinical trials didn't measure infection/transmission (which is very hard to do in a clinical trial) with the distinct claim that they didn't reduce transmission in reality. The vaccines were extremely effective at reducing transmission during the first waves of COVID, where such an intervention was most valuable. And due to viral growth dynamics,…
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Ah, one of those "everybody knows" argument that is on the level of "everybody knows that Napoleon was short".
It's not completely wrong but it ignores important context. The part you are leaving unsaid is that the vaccine reduced transmission even if it didn't prevent it completely. 80% reduction is a significant amount.
Wearing masks on top of that was the sensible thing to do.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#184Earlier quoted context omitted.
I don’t think this is correct, Black people still get sunburns
This is an illusory statistic because "black people" isn't a real category. People who self-identify as "black" have a wide-range of skin tones. Even a moderate bit of brown completely eliminates the risk of sunburn. You can have two "black" parents and be lighter skinned than the average southern Italian. I say this from experience. I am a black person who is not particularly dark skinned, and have only had the slig…
I’m overwhelming white ancestry but with some remnant traces of melanated ancestry (> 1%) and I tan very easily. I’ve been mistaken for hispanic or Black before during the summer. My mom is much darker than me.
We both get sunburns. My even darker grandmother got sunburns. My Black friends get sunburns. I am not sure that you are correctly correlating your experience with actual facts about the sunburn resistance offered by melanin.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#185Earlier quoted context omitted.
I’ve always wondered about this. I have fair skin, and I tend to burn somewhat easily in very sunny environments like the beach. However, I’ve never gotten so much as a whisper of sunburn / suntan / anything on an actually cloudy day where sun wasn’t hitting me directly. Is the damage a different type that’s imperceptible? Or is this a public health comms strategy where they assume people will see a single cloud in t…
I’ve gotten visibly sunburned on cloudy/foggy days, where it was completely overcast. You may have gotten lucky.
IIRC, certain types of hazy high clouds can actually make the UV exposure worse. Personally, I got the worst sunburn of my life on a cloudy day.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#186Earlier quoted context omitted.
I don’t think this is correct, Black people still get sunburns
Black people who spend all their time indoors or covered up will get sunburned if they go outside. If that black person gradually increases their sun exposure they can (in a few weeks) reach the point where they can be outside without sunscreen and they will not get sun burned. Note that I'm making no claims on how natural sunburn resistant affects skin cancer.
The same is true for me, a white person of northern European heritage. If I have a few weeks and time to work at building up a tan, I can get to the point where I won't burn. I did this during the pandemic when I was home all day. I would go out and lie in the sun, starting at 15 minutes, turn over, go another 15 minutes, and go back inside. Increased the time as my skin darkened. Felt nice, never burned.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#187Earlier quoted context omitted.
I think the point is just about temperature. I've experienced this out on lakes in the northern US for example. It's sunny but not like a tropical beach, and maybe even a little chilly. But you'll definitely get burnt without sunscreen
People who are new to skiing/snowboarding are often surprised that their faces get sunburned, because of course it's cold and so how could they get burned
And snow makes it worse by reflecting.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#188Earlier quoted context omitted.
What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…
We developed creams that stopped sunburn, but were still great at getting you cancer. A lot of the ads from 70s and 80s talked about how they stopped UVB but let the tanning UVA through! So yes, they didn't burn, but the long term cancer rates exploded, along with all the skin aging. So it's not that they ignored the all knowledge. I blame most of it on the rather detrimental tech advancement. Like cigarettes with fi…
> We developed creams that stopped sunburn, but were still great at getting you cancer.
I thought you were going to talk about the ingredients in the cream were carcinogenic themself.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#189Earlier quoted context omitted.
I didn't know about the UV index or what it meant until like three years ago. It blows my mind I went that long without understanding. It was actually wonderful to learn that I could just see if I needed sunblock based on a 0-10 scale. We never wore sunscreen as kids because we didn't burn. I probably have had three sunburns in my life. Learned once I became an adult that that wasn't sound logic...
I think the Apple Watch or the Weather app or something finally taught me UV index about the same time. Has this information always been readily available? Similarly mind blown about it.
In Australia in at least the 00s, possibly the 90s, I remember it being reported during the weather forecast on the 6pm nightly news.
But Australia has always had a famously robust sun health education programme
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#190Earlier quoted context omitted.
Pretty sure a bad sunburn sucked back then as much as now, and was something one tried to avoid.
Unless you are albino (which is a large set of other problems) being in the sun all day will develop enough of a tan that you won't sunburn. There might be a problem in spring, but by summer time most people will have spent enough time outdoors that they wouldn't sunburn. I've always been the lightest person in town (a tie in Stockholm) and I can spend all day outside without any sunscreen and I won't burn on the par…
Fascinating. Now come and try that on the Arabian peninsula and see how you get on