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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#171

Post by foco_tubi »

bluGill wrote: post #160
foco_tubi wrote: post #145

Earlier quoted context omitted.

I don’t think this is correct, Black people still get sunburns

Black people who spend all their time indoors or covered up will get sunburned if they go outside. If that black person gradually increases their sun exposure they can (in a few weeks) reach the point where they can be outside without sunscreen and they will not get sun burned. Note that I'm making no claims on how natural sunburn resistant affects skin cancer.

Increased melanin provides some protection against burns, but it doesn’t make you immune. There’s also the aspect of UV damage without burns, which is still harmful and is not affected by melanin levels.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#172

Post by dfee »

raverbashing wrote: post #166
wincy wrote: post #88

Earlier quoted context omitted.

What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…

Everybody who's not been raised in a bubble knows the sun burns It's only recently that we had space for completely retarded ideas like "staying in the sun doesn't hurt you" or "sunscreen causes cancer"

> It's only recently that we had space for completely retarded ideas like "staying in the sun doesn't hurt you" or "sunscreen causes cancer"

but, what if staying in the sun isn't binary?

and, what if everyday products did cause cancer? https://www.health.harvard.edu/cancer/cancer-concerns-from-e...

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#173

Post by calebkaiser »

HedonicEscal8r wrote: post #108
calebkaiser wrote: post #60

Earlier quoted context omitted.

1. That's not what progression-free survival means. 2. I don't think AI was mentioned once in this press release. 3. This drug was approved for trial in 2014, so if it had something to do with deep learning, that would actually be a massive announcement. 4. The paragraph immediately following the one you clipped talks about Overall Response Rate (ORR) and throughout the release they discuss Overall Survival (OS). 5.…

Interjecting with a fact. Moderna described the neoantigen immunogenicity prediction algorithm they used to design the vaccines as “a deterministic machine learning (ML) algorithm,” so it may be a small neural network or more traditional algorithm, probably not deep learning.

Sorry--I was unclear. I was specifically responding to the OP's "CEOs these days want to join the AI hype wave" claim. My point was that the "hype wave" OP is referencing is really about deep learning, not what we think of as traditional statistical learning. Even the dedicated medical AI startups of that era, like BenevolentAI, were still doing traditional ML in 2014. So if Moderna really was trying to join the "AI hype train" and announce a deep learning result with this treatment, they'd be announcing that they successfully trained a deep neural network for drug discovery 12 years ago.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#174

Post by pessimizer »

foco_tubi wrote: post #145
bluGill wrote: post #139

Earlier quoted context omitted.

Unless you are albino (which is a large set of other problems) being in the sun all day will develop enough of a tan that you won't sunburn. There might be a problem in spring, but by summer time most people will have spent enough time outdoors that they wouldn't sunburn. I've always been the lightest person in town (a tie in Stockholm) and I can spend all day outside without any sunscreen and I won't burn on the par…

I don’t think this is correct, Black people still get sunburns

This is an illusory statistic because "black people" isn't a real category. People who self-identify as "black" have a wide-range of skin tones. Even a moderate bit of brown completely eliminates the risk of sunburn. You can have two "black" parents and be lighter skinned than the average southern Italian.

I say this from experience. I am a black person who is not particularly dark skinned, and have only had the slightest sunburn once in my life, after I had been working in a field for 16 hours straight in full sun under clear sky detasseling corn. When I got back to camp, the back of my neck seemed slightly sensitive, which was unusual. It was fine the next morning, and never peeled at all. I did the same for 2 weeks, and this was the only time I felt this. This was the worst sunburn (if it was one) that I've gotten in 50 years of life. I've spent plenty of time outside, and plenty of time inside being a code monkey and never going outside. I've never worn sunscreen.

I've never met a black person as brown as a paper bag who ever got a sunburn, at least that I know of. My dad is pretty pale, I think I would have heard about it.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#175

Post by john_strinlai »

pessimizer wrote: post #170
HedonicEscal8r wrote: post #120

Earlier quoted context omitted.

Yes, but OP said that in response to a comment attributing melanoma to sun exposure, in a conversation where nobody had brought up SCC or BCC. It's still a misleading comment, in my opinion.

> Yes, but OP said that in response to a comment attributing melanoma to sun exposure, in a conversation where nobody had brought up SCC or BCC. In a thread about a trial for a melanoma drug, which has nothing to do with the discussion of sunscreen. Sunscreen was brought up because it is a culture-war topic, the fact that melanomas are not as associated with sun exposure was brought up as the standard opposite-side r…

>Clearly your unrelated accusation was brought up to silence the other side and accuse them of dishonesty. Your follow-up is to accuse them of some conversational violation (mentioning something that wasn't brought up) which doesn't exist.

the comment you are replying to is HedonicEscal8r's first comment in this comment chain.

>that one sentence reply is already trying to snowball into a pile on

no... it is correcting your comment that is accusing HedonicEscal8r of having multiple comments in this chain. HedonicEscal8r was not the one to make the comment that you describe as an "unrelated accusation" to "silence the other side".

common courtesy would be to say "oops, i didn't read the usernames, my bad" instead of accusing someone else entirely of "trying to snowball into a pile on" for calling you out on the mistake.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#176

Post by onlyrealcuzzo »

hummuscience wrote: post #131

My father is currently dying of malignant melanoma with brain metastasis... I wish this treatment was available a few years ago.

I'm so sorry to hear that, but thank you for sharing your story to highlight the importance of this!

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#177

Post by pfdietz »

DaSHacka wrote: post #150
bhaak wrote: post #14

Earlier quoted context omitted.

What are the reasons for the hate of the COVID vaccine?

Mostly that it was forced unneccessarily on everyone, even those who did not benefit from it, if I had to guess.

Forced on everyone? That's a thing that didn't happen.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#178

Post by kaikai »

jihadjihad wrote: post #136
wincy wrote: post #88

Earlier quoted context omitted.

What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignoran…

> before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you. I'd say partly true, mostly false. As sibling comment mentions, much of this was driven by fashion and class etc. and not from some fundamental understanding of damaging UV exposure. Furthermore there was research that was trendy at the time called "heliotherapy" [0] where all sorts of diseases were b…

When I got chickenpox in the 80s my grandma made me sit out in the sun to heal it faster. Heliotherapy lives on!

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#179

Post by kaikai »

senordevnyc wrote: post #130
Insanity wrote: post #21

Earlier quoted context omitted.

+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.

I’ve always wondered about this. I have fair skin, and I tend to burn somewhat easily in very sunny environments like the beach. However, I’ve never gotten so much as a whisper of sunburn / suntan / anything on an actually cloudy day where sun wasn’t hitting me directly. Is the damage a different type that’s imperceptible? Or is this a public health comms strategy where they assume people will see a single cloud in t…

I’ve gotten visibly sunburned on cloudy/foggy days, where it was completely overcast. You may have gotten lucky.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#180

Post by bonsai_spool »

pigeof wrote: post #157
bonsai_spool wrote: post #113

Earlier quoted context omitted.

Please be careful and charitable in reading others' words, especially as they relate to scientific topics. OP did not say that melanoma has no sun exposure risk but that it is lower than the risks associated with other cutaneous cancers (e.g., SCC and BCC) and it would seem that's true based on the very short search I performed. https://pmc.ncbi.nlm.nih.gov/articles/PMC5742376/

The criticism and correction were polite, helpful, and appropriate. The original comment is misleading. Your reply is bizarre, and seems to deliberately misread the original comment, the reply, and the context.

> misread the original comment

By pointing out that it is true using a reference?

> the reply

The reply misunderstood the first comment and went on to discuss something a)interesting but b) not germane to whether melanoma is the skin cancer with the highest sun exposure risk.

I have no idea what you mean by context as this small discussion is quite self-contained. Think of this as making sure everyone realizes two homophones actually are distinct words.

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