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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#21

Post by Insanity »

GenerWork wrote: post #4

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#22

Post by jjice »

Insanity wrote: post #21
GenerWork wrote: post #4

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.

I didn't know about the UV index or what it meant until like three years ago. It blows my mind I went that long without understanding. It was actually wonderful to learn that I could just see if I needed sunblock based on a 0-10 scale.

We never wore sunscreen as kids because we didn't burn. I probably have had three sunburns in my life. Learned once I became an adult that that wasn't sound logic...

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#23

Post by bluGill »

MartinMond wrote: post #9

I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the...

I don't believe the efficient market hypothesis. However even if you do, new information has arrived and that will affect the price.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#25

Post by bpodgursky »

Jyaif wrote: post #17
consumer451 wrote: post #8

This appears to be a potentially huge win for health. The market has Moderna up 153% at time of writing, which is some sort of validation I suppose. Related stories: https://www.fiercebiotech.com/biotech/merck-and-modernas-per... https://www.reuters.com/legal/litigation/merck-moderna-say-m... https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ...

oh nice. If it goes up another 100% I may not lose money on this stock anymore.

And if it doubles after that, I may even beat a passive S&P 500 investment.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#26

Post by pipolo »

MartinMond wrote: post #9

I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the...

Hard to price in the political factors now involved in Moderna's success or lack of success.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#27

Post by zulux »

Someone1234 wrote: post #13
reenorap wrote: post #12

[flagged]

> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

[flagged]

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#28

Post by tasty_freeze »

bhaak wrote: post #14
reenorap wrote: post #12

[flagged]

What are the reasons for the hate of the COVID vaccine?

There is a legitimate discussion of what can be mandated you do to your body.

However, that discussion was largely side-tracked by the massive amount of disinformation (eg, "Plandemic") that circulated online. There are people who to this day swear that COVID-19 was just like the flu and simultaneously claim that the vaccine spike proteins have killed around 20M people. Not just crackpots, but people with reach, like Brett Weinstein on Joe Rogan's podcast.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#29

Post by estearum »

jimbo808 wrote: post #10
tnel77 wrote: post #3

Earlier quoted context omitted.

Why?

People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived. Yet Yale-led researchers later detected circulating S1 and full-length spike as late as 709 days after vaccination. They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. That is a massive ga…

> They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage.

Not true. This was correctly disclosed in the trial results as a super super super tail risk.

Once they realized that the (minuscule) risk could be even further mitigated by simply spacing out the booster schedule, they adjusted that (Feb 2022).

Nobody was "left in the dark"

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#30

Post by estearum »

Insanity wrote: post #18
declan_roberts wrote: post #15

Earlier quoted context omitted.

Probably one of the most polarizing issues of the last 5 years.

I don't recall it being as polarizing outside of the US, where there was a larger group of anti-vaxxers to begin with. But that might be my "outside US" bubble.

And, critically, a malignant narcissist in the highest office.
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