Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#2[flagged]
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#3[flagged]
Why?
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#4This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#5Ever since I first heard of them a decade ago, it seemed that mRNA therapeutic vaccines were going to be the next wave of massive improvements in care. It's taken a bit longer than I had expected, and it's not that mRNA is the only way to make these sorts of vaccines, it's just so much better than the alternatives.
I'm very very excited to see what comes next.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#6Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#7Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#8This appears to be a potentially huge win for health. The market has Moderna up 153% at time of writing, which is some sort of validation I suppose.
Related stories:
https://www.fiercebiotech.com/biotech/merck-and-modernas-per...
https://www.reuters.com/legal/litigation/merck-moderna-say-m...
https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ...
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#9I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the...
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#10[flagged]
Why?
People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived. Yet Yale-led researchers later detected circulating S1 and full-length spike as late as 709 days after vaccination.
They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage.
That is a massive gap between what the public was told and what later evidence found. If a technology makes your cells produce a biologically active protein, regulators should establish where it goes, how long it can persist, and what prolonged exposure does before mass deployment.
https://news.yale.edu/2025/02/19/immune-markers-post-vaccina... https://www.medrxiv.org/content/10.1101/2025.02.18.25322379v...