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Global review confirms mRNA vaccines are safe, effective and full of promise

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Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#511
post #508

Earlier quoted context omitted.

See my other comment answering this. It's only higher if you don't trust peer reviewed research, and instead use the numbers provided by the drug company in a study that was not peer reviewed. See the list of peer reviewers in Pfizer's study and notice that they are the same as the researchers, and that they've made claims without providing their results (those are still being released over an 80 year period by FOIA…

> those are still being released over an 80 year period by FOIA court order, you'll get the results when we're all dead Are you referring to this [0]? It was solved years ago. The study I posted in this thread that you're posting in is a peer-reviewed retrospective cohort study out of Spain. What is wrong with it? [0] https://www.denvergazette.com/2022/01/07/judge-scraps-75-yea...

I wasn't aware that it was expedited, but I also wasn't able to find the documents. I did find that they were sued again to release them in Dec. 2024.

https://www.reuters.com/legal/government/fda-must-disclose-m...

So, at least until then they continued to hide them.

Do you have a link to the documents, or any subsequent meta study?

And then we still need to resolve the issue of peer review.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#512
post #507

Earlier quoted context omitted.

Can you show me that math? Your premise is that COVID infection at just 5% is incredibly dangerous. But you can't actually say that without first knowing how many people were actually infected and asymptomatic. And you don't know that. For all we know, everyone was infected, and infection is nearly harmless. Or it could be that it's way less contagious than that, and extremely deadly. You simply don't know. You'd nee…

70/100k is baseline. 5/100k is vaccination. 200/100k is unvaccinated with covid. With vaccination you're at 75/100k. Without vaccination at 0% chance of covid you're at 70/100k. Without vaccination at 5% chance you're at 77/100k (worse than 75 here), at 10% 83, etc, etc. > We're supposed to be doing science, right? Seems to me your premise is the one that's unrealistic. Mine is firmly grounded in evidence that we DO…

See section 2.4. The "unvaccinated" group includes people with a history of myocarditis and pericarditis who had an episode during the study, and coupled with the fact that cases "without an episode" were excluded, we should expect that the numbers are very much inflated.

There indeed are plenty of studies linked. I'm not ignoring them, I'm using them to point out that they don't carry the implications necessary to recommend vaccination for everyone.

To make the claim that the vaccine LOWERED incidence of myocarditis even for those without covid, counter to so much other research (e.g. [0]), we would like to see that the study excludes people with a history of myocarditis.

Including them is cheating, quite simply.

Regardless, even if we did go with this Spanish study, you still can't say that a 5% chance of infection is worse. You can say that a 5% of symptomatic infection is worse. There isn't any study in the thread that includes asymptomatic infection, which we know is MOST infection.

So at least so far, I don't see that you have the math to back what appears to be an unscientific claim.

And when faced with the counter research below [0], defining the mechanism of action, we should assume that the risks are a valid concern. You can't just sweep them under the rug.

Most people who tested positive had no symptoms. Most people who didn't get tested also had no symptoms but were likely infected. All of those people shouldn't take on additional risk in their own self interest. At best you can claim that they should take on the risk to try to achieve herd immunity so as to protect others. And actually I'm not sure that we have the data to determine that either.

[0] https://med.stanford.edu/news/all-news/2025/12/myocarditis-v...

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#513

Serious question in good faith: what was the deal with the “calamari” (clots?) the anti-vax crowd kept talking about being found in the veins/arteries of folks who took the Covid vaccine?

> the anti-vax crowd kept talking about being found in the veins/arteries of folks who took the Covid vaccine?

"The deal" is the clot issue was a problem for Astrazeneca. Astrazeneca is not an mRNA vaccine. It came out first, and was offered to a lot of people - until the clots started showing up.

Australia's response (where I live) was to withdraw the Astrazeneca vaccine and go into lockdown instead. They exited lockdown once a safe replacement vaccine was manufactured and could be mass administered, which happened many months later. The safe replacements were predominantly mRNA vaccines.

From memory the final statistics were Astrazeneca, which was only available for a month or two killed 1 in every 1 million doses, the mRNA replacements which now have been used for years have caused about 1 death for every 55 million doses. You wouldn't want to be the unlucky 1 in 55 million, but you would not want to miss out on taking the mRNA vaccines either - they saved 1000's of lives.

In the high risk groups, Astrazeneca turned out to be worth its risks in over-60s in Australia, but killed more people than it saved in the lower risk groups. But Australia was among the best countries to manage the COVID pandemic. In countries like Mexico where the death rates from COVID were far higher, taking Astrazeneca increased your chances of surviving the pandemic, despite the higher complication rate.

The meme that mRNA causes clots seems to be remarkably common, despite being wrong. It is why to this day many people are vaccine hesitant. It's unfortunate. I think the underlying cause of the large number of people with clots was the mass roll out of Astrazeneca as soon as it passed testing. Normally the take up of a new medicine is gradual. The high prices of the early batches mean they are only given to people who stand to benefit most. The less common side effects are caught in that phase. The phase didn't happen for Astrazeneca.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#514
post #266

Earlier quoted context omitted.

Would that large trial have shown the cancerous effect of smoking? If not, do you then agree that some possible adverse effects were not checked for and could have slipped through?

Don't know. But would standard smaller trials have captured it? We are kind of back to my initial question that is conceptually unrelated to the vaccine trial: do you need trials to run into millions or billions of participants or into decades if you want to capture certain (rare) things?.

Maybe, if you want to mandate the entire country/world takes the intervention?

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#515
post #468

Earlier quoted context omitted.

You are being too patient. Reading this, just look at their contradictory behavior, one one hand they thrice called you lazy, curious, and upset (all ad hominems, attacks on motive), meanwhile they outwardly frame themselves as a steward of science institutional literacy/legitimacy and passive-aggressively "shoulding" everyone else, twisting that expressing any critique is just failing to use "information". There's t…

“Government must inject information directly into my brain at precisely my literacy and curiosity and intelligence level. Failure to do so is THEIR fault, and not an indictment of my literacy, curiosity, or intelligence.”

No, government must not do any such thing. They must back away, as my literacy, curiosity and intelligence is not their business in the slightest. Nobody owes anything to government, especially trust. But if "government" insists on importance of things they communicate, it is absolutely on them to ensure it is calibrated to everyone's profile. And I still am not obliged to trust them. Once a liar always a liar.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#516
post #507

Earlier quoted context omitted.

70/100k is baseline. 5/100k is vaccination. 200/100k is unvaccinated with covid. With vaccination you're at 75/100k. Without vaccination at 0% chance of covid you're at 70/100k. Without vaccination at 5% chance you're at 77/100k (worse than 75 here), at 10% 83, etc, etc. > We're supposed to be doing science, right? Seems to me your premise is the one that's unrealistic. Mine is firmly grounded in evidence that we DO…

See section 2.4. The "unvaccinated" group includes people with a history of myocarditis and pericarditis who had an episode during the study, and coupled with the fact that cases "without an episode" were excluded, we should expect that the numbers are very much inflated. There indeed are plenty of studies linked. I'm not ignoring them, I'm using them to point out that they don't carry the implications necessary to r…

In retrospective cohort studies, researchers track newly occurring incidents during the study window.

If someone has a history, but suffers a new episode from covid, that is a medical event that should be counted.

> Regardless, even if we did go with this Spanish study, you still can't say that a 5% chance of infection is worse. You can say that a 5% of symptomatic infection is worse.

Yes you can. The mechanism for the side effect (as per your own source) is the same in both symptomatic and asymptomatic cases. Recipients of the vaccine do not get respiratory symptoms, and yet can contract the (very rare) side effects.

And as for your source, the author, Dr. Joseph Wu:

> “But COVID’s worse,” he added. A case of COVID-19 is about 10 times as likely to induce myocarditis as an mRNA-based COVID-19 vaccination, Wu said. That’s in addition to all the other trouble it causes.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#517
post #516

Earlier quoted context omitted.

See section 2.4. The "unvaccinated" group includes people with a history of myocarditis and pericarditis who had an episode during the study, and coupled with the fact that cases "without an episode" were excluded, we should expect that the numbers are very much inflated. There indeed are plenty of studies linked. I'm not ignoring them, I'm using them to point out that they don't carry the implications necessary to r…

In retrospective cohort studies, researchers track newly occurring incidents during the study window. If someone has a history, but suffers a new episode from covid, that is a medical event that should be counted. > Regardless, even if we did go with this Spanish study, you still can't say that a 5% chance of infection is worse. You can say that a 5% of symptomatic infection is worse. Yes you can. The mechanism for t…

You're not addressing the issue. 5% of what?

5% of symptomatic COVID cases. So now you have to compare that to only people with injuries from the vaccine.

Otherwise you're comparing apples to oranges.

If you want to compare people who got the vaccine to people who didn't, then you need to include ALL people who didn't. Not just the ones who were symptomatic.

And no, you can't include those people who had previous symptoms in the "everyone" group. Obviously those people are way more likely to return for treatment than the average Joe. They are skewing the sample because they are immediately nearly 100% likely to return for treatment. That is not representative of a random sample of people in the general population.

The question was about the general population, and they didn't sample the general population. They sampled people who come to the hospital. That is, only people with symptoms of some sort or another that are bad enough to warrant a journey to get treatment.

So all you can conclude is that people who come to the hospital have a higher frequency of heart conditions. And even that claim is not firmly established by the data, it's just a sensible inference. We expect that people who need treatment are more likely to seek treatment than those that don't need it. But there are countless counter examples there too. Hypochondria, etc.

No doubt if we had the data we'd find more problems there.

Wu's statement is fine, because again, it's not ALL people with COVID. His statement holds for people seeking treatment with COVID which is what they sampled.

Wu has no clue how many people have COVID asymptomatically and how to separate them from people without COVID altogether, and makes no claim about that.

You're simply making a claim that isn't in the research. Vaccination for people without COVID or with asymptomatic COVID is not researched or compared here.

This research, if you want to use it for a comparison, is for vaccination of people already coming to a hospital with symptoms of some kind.

EDIT: forgot to mention this was during a pandemic, so you might see significantly lower numbers for heart conditions if the study was repeated today. And it might be the case that during the pandemic it would have been a good idea to vaccinate everyone coming to a hospital from a statistical standpoint. But an even better take would be to identify what was common amongst the group with bad outcomes and vaccinate them, more specifically.

Regardless, nothing here implies better outcomes for everyone. It's not claimed by and it's not inferable from the research. And certainly not when there is a bunch of research showing contrary results to this study an example of which I linked earlier.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#518
post #482

Earlier quoted context omitted.

im no forever masker or anything, but this is false. we just now have to live with a slightly elevated death rate due to covid

>a slightly elevated death rate due to covid Is that a fact? Do we now have a higher all cause mortality rate from pre-covid era?

No. And even during covid the all cause mortality rate was below pre 90s rates.

https://www.statista.com/statistics/189670/death-rates-for-a...

The highest cause was heart disease (~680K) which has a best preventative step of maintaining at least 150 minutes of moderate exercise weekly. Between 45% to 50% of Americans, of any age, are estimated to have done that.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#519
post #516

Earlier quoted context omitted.

In retrospective cohort studies, researchers track newly occurring incidents during the study window. If someone has a history, but suffers a new episode from covid, that is a medical event that should be counted. > Regardless, even if we did go with this Spanish study, you still can't say that a 5% chance of infection is worse. You can say that a 5% of symptomatic infection is worse. Yes you can. The mechanism for t…

You're not addressing the issue. 5% of what? 5% of symptomatic COVID cases. So now you have to compare that to only people with injuries from the vaccine. Otherwise you're comparing apples to oranges. If you want to compare people who got the vaccine to people who didn't, then you need to include ALL people who didn't. Not just the ones who were symptomatic. And no, you can't include those people who had previous sym…

No? It's population cohort study, not a hospital clinical sample. You're simply wrong in your assertions.

You can absolutely track asymptomatic infections through seroprevalence studies which we have been doing since 2020.

> forgot to mention this was during a pandemic, so you might see significantly lower numbers for heart conditions if the study was repeated today.

Yeah, that's making the point for me.

Re: Global review confirms mRNA vaccines are safe, effective and full of promise 

#520
post #519

Earlier quoted context omitted.

You're not addressing the issue. 5% of what? 5% of symptomatic COVID cases. So now you have to compare that to only people with injuries from the vaccine. Otherwise you're comparing apples to oranges. If you want to compare people who got the vaccine to people who didn't, then you need to include ALL people who didn't. Not just the ones who were symptomatic. And no, you can't include those people who had previous sym…

No? It's population cohort study, not a hospital clinical sample. You're simply wrong in your assertions. You can absolutely track asymptomatic infections through seroprevalence studies which we have been doing since 2020. > forgot to mention this was during a pandemic, so you might see significantly lower numbers for heart conditions if the study was repeated today. Yeah, that's making the point for me.

Respectfully, I think you've mistaken the definition of the word cohort . A cohort specifically does not include everyone. Please check the definition of cohort and then read section 2.4.

They tested people treated at a small collection of hospitals (the cohort).

And, you have made several other mistakes aside from that.

The 2020 studies are all retracted. They were over-spinning the centrifuges, I think by a factor of 10 or 100 maybe? They got insanely high positive numbers and the guidance was all updated to correct for that. You can ask an LLM to help you find the CDC publications on that. Don't use those numbers.

Additionally, even if your interpretation was accurate, it would fly in the face of thousands of other studies, just like the one I posted earlier in the thread.

Make sure your beliefs are based on peer reviewed research, that is not retracted, has been established long enough to withstand challenges from the scientific community, and that you're interpreting it honestly, using the established academic criteria for the scientific method and publication standards. Be careful to check the definition words that you're not familiar with, and even ones that you think you're familiar with. They might have a different meaning when used in a scientific context.

Out of curiosity, are you a journalist, college educated? I'm trying to understand where science has failed here. I would like our institutions to produce adults that can identify sound research and draw logical conclusions. There are some basic methods for doing that. I don't mean any offense by that. I'm just trying to understand what's broken. And more to the point, whether or not you are actually interested in science or you're just trying to prove that the media knows more than the scientists. Or maybe you just can't believe that journalists lie about what scientists say.

Is the media in the business of selling truth for profit, even if it means they won't profit? Do you believe that enough to take drugs that legally restrict you from taking legal action against the manufacturer when you're injured? (See CARES act)

Is your motivation to continue discussion political? Or scientific? If it's scientific, let's stick to the facts and follow the science. Don't try to make the science say what you want. You'll find that doesn't work in the broader forum.

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