Previous discussion: https://news.ycombinator.com/item?id=46283089
Frog-derived gut bacterium eradicates tumors in mice
191–200 of 207 posts
Re: Frog-derived gut bacterium eradicates tumors in mice
#192Earlier quoted context omitted.
Spoken like someone who has never had to rebuild a generator or find out the hard way car wiring is mainly soy-based nowadays.
Wrapping your wiring harness in capsaicin tape works pretty well. Unfortunately, this is a discovery I made after multiple annoying and expensive repairs.
Yeah, I went with spray and a monthly reminder to stalk the entire premises for The Enemy, but same idea.
Re: Frog-derived gut bacterium eradicates tumors in mice
#193Earlier quoted context omitted.
>For a Sean Connery movie it was bizarre Buddy, if you're trying to tell me it's weirder than Darby O'Gill and the Little People, I am going to need more than Sir Connery in a ponytail.
> I am going to need more than Sir Connery in a ponytail Check out Zardoz: Connery with a ponytail, a pistol in hand, wearing thigh-high boots and a mankini. And a giant flying stone head that vomits guns. I am not joking.
Oh, I didn't need you to say more than Zardoz to bring that beautiful memory back.
Re: Frog-derived gut bacterium eradicates tumors in mice
#194Earlier quoted context omitted.
>For a Sean Connery movie it was bizarre Buddy, if you're trying to tell me it's weirder than Darby O'Gill and the Little People, I am going to need more than Sir Connery in a ponytail.
Yeah, with a movie like that in his credits, it seems a miracle he was ever selected to be James Bond. His radar for picking great movies was equally bad as it was good.
I think he was one of those people that was acting to keep the lights on well after he was set for life. It's a mindset, especially depending on how you grew up.
Re: Frog-derived gut bacterium eradicates tumors in mice
#195Re: Frog-derived gut bacterium eradicates tumors in mice
#196Earlier quoted context omitted.
I lived under both systems. Yeah, socialism was abandoned precisely because capitalism was better. By the 1980s, residents of Central Europe could quite clearly compare and saw that their western neighbours were richer, healthier and enjoyed cleaner air and water than those of the "Camp of Progress". Market economy + democracy beats top-down enforced utopian intellectual projects like a Marxist-Leninist state by a di…
You prefer capitalism because you live privileged and weigh short term wealth higher than long term effects of capitalism. Personally I'd much prefer not exploiting 3rd world countries to fund first world consumerism.
> privileged
Yeah, being born in rust belt of the former Eastern Bloc was a privilege like hell. You don't know what you are talking about. If you visit places like Chisinau, you'll get a glimpse of Ostrava cca 1994.
What are the long term effects of the systems that you push? Can you even model them?
Long term effects of Soviet-style Communism were ghastly. Dried lakes, poisoned rivers, mass graves, all in the name "of the people".
Non-market economies can only be sustained by constant violent repression and censorship, and the incentives in such systems where prices aren't serving as a signal are totally out of whack, resulting in extreme waste on one side and constant shortages on the other.
The absolutely worst thing that liberated African and Asian countries did was to introduce Marxist economies. Fortunately most of them already realized just how deep that hole goes. Economic liberalization in India alone will likely lift a billion people out of poverty in mere 20 years or so.
Re: Frog-derived gut bacterium eradicates tumors in mice
#197Earlier quoted context omitted.
it's in the first book
Oh man my memory is shot then
Maybe you just didn't really see it. I've begun to notice that I don't even see certain things that I read, especially if I'm not intellectually prepared to receive them. I vaguely remembered the mice and the earth being a computer (once prompted by the post), but I had no idea about the mice being 3D projections of a multi-dimensional being. I'm pretty sure that idea was either not something I truly comprehended at 20 and/or I thought it was stupid/random (my opinion on the book as a whole), so the thought never even sank in.
Other times I just don't see something for other reasons. I read Augustine's Confessions and never saw the famous line "our hearts are restless until they find their rest in Thee", which is in the THIRD sentence! I'm not sure if the antiquated English [1] threw me off, or what. In fact, I don't remember seeing pretty much every quote people take from Confessions, besides the pear episode. Some of those are theological ideas that are just completely new, some are probably my annoyance at his "confessing" things that aren't really faults [2], and my annoyance at his insistence on quoting the Bible everywhere he could [3]. But I find it strange that I seemed to have simply not seen most of what other people get out of it.
[1] Rant: don't bother reading the out of copyright translations of ancient works, because the 1800s and early 1900s seemed to think that because the works are old, it should be translated into old English. This is stupid. Augustine didn't write in 500 year old Latin, so translating it into 500 year old English is mistranslation.
[2] I am starting to think that maybe "confess" might have meant something different, and it is not confessing a faults but a statement of beliefs.
[3] I suspect that ancient ideas of rhetoric valued quoting trusted sources a lot, kind of how classical Chinese literature quotes older classic literature a lot. Augustine, being a professional rhetorician, would in that case be expected to do that. But it drove me nuts.
Re: Frog-derived gut bacterium eradicates tumors in mice
#198Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mic…
I disagree that the title "hides" that the title was small and that it disappeared for two weeks. The surviving contingent on the E. americana strain was evaluated for 60 days, and the tumor doesn't look particularly small based on the picture on page 8 of the paper. I think the study size is small (n=5) so we'd like to see more large-scale studies next, but it's already a strong result to show 5/5 (100%) at p < 0.00…
> The surviving contingent on the E. americana strain was evaluated for 60 days
The article says
> The surviving contingent on the E. americana strain was evaluated for 60 days (Supplementary Figure S5).
The supplementary material only shows a reshot with cancer cells at the day 30. All the other parts also days a total of 60 days. At day 0 the cancer cells were injected, approximately at day 10 the bacteria were injected, and approximately at day 20 the cancer disappeared. So correct my initial comment and say that it's 40 days cancer free.
When the title says "eradication" most people interpret "forever". That is too optimistic and unrealistic, but a 5 years survival rate is somewhat a standard point. 15 or 40 days is too short to know if there are some hidden metastasis, they need more time to grow and be visible.
Also, the initial treatment is only 10 days after the initial shot with cancer cells. IIRC it's an aggressive cancer variant in mice variant that has a crappy inmune system. Gut cancer in humans are detected when they block the guts or bleed or in periodic colonoscopy every few years, so they usually have more than 10 days to develop before detection.
Note that this setup in mice is good for initial test and to filter the promising treatments as they did, but it's difficult to extrapolate to long term treatment of humans.
Re: Frog-derived gut bacterium eradicates tumors in mice
#199Earlier quoted context omitted.
Certainly lots could be said here, but first and foremost its more than a little weird to be so fixated on that Greta girl like this.. You should really, like, work on making your point without bringing her up maybe? Maybe try writing two sentences not talking about her and go from there? I am not sure you appreciate how much it takes away from you point... Like, oh no, are you going to say something bad about Al Gor…
He should have sprinkled the word Nazi in a few times to modernize it
Nay, I don't speak TikTok. As to the 'antiquated parlance' I'd say it is what you use when discussing eschatology with religious fanatics.
Re: Frog-derived gut bacterium eradicates tumors in mice
#200Earlier quoted context omitted.
The planet is fine friend. The cool thing about the relentless march of technology is that we will eventually fix anything we break along the way. There is no limit to what we can achieve. There is certainly nothing you can do about it so go outside, lie by the pool or the ocean, enjoy life.
>is that we will eventually fix anything we break along the way Thats the most dangerous thought one could have. Simply thinking "its okay because we can fix it later" leads to taking issues lightly and hoping that a fix is eventually discovered in time. We run out of time with climate change for example. There are no fixes.
There are no fixes via social engineering or laws.
Asia and Africa are coming up, they are not going to sacrifice their econonomies becuase the western world which is already established has some people saying hang on, we've got ours, you need to wait. They are going to be building massive coal plants and burning barrels of oil. So Bob in France not turning on his AC is not going to make any difference.
We will fix it later, I'm not worried about it becuase there is nothing to be done about it. Worrying and panicking about it does no one any good.
Technology marches forward.