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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#151

Post by faangguyindia »

phil21 wrote: post #122
9x39 wrote: post #96

Earlier quoted context omitted.

I think you dislike the personal responsibility angle, which is fine but separate from caloric intake being the source of obesity. The fat is stored energy from food, it would violate conservation of energy otherwise. There's metabolism, food density, food availability, psychology, culture, economics, etc in play, but it's important not to lie to ourselves that the proximal cause of obesity isn't from over consumptio…

Who is lying? I was fat because I ate too much. Why I ate too much is uninteresting to me. I also don’t have some moral hang up over it. Give me that easy button all day long so I can focus on shit in my life that actually matters. If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works?

if there is no resistance, simply prescribing GLPs to average person may become a new normal.

Re: What Ozempic does to the gut-brain axis

#152

Post by ceejayoz »

faangguyindia wrote: post #139
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

What if you could intentionally eat good food?

I've heard it widely described as reducing mental noise around food.

Re: What Ozempic does to the gut-brain axis

#153

Post by faangguyindia »

barake wrote: post #39
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person.

So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?

Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations.

Don't quote me on this; I am paraphrasing things I remember from.

Re: What Ozempic does to the gut-brain axis

#154

Post by crooked-v »

htk wrote: post #150
wpm wrote: post #21

Earlier quoted context omitted.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

No, the symptom is being treated, not the underlying issue. And that's ok, but treating the underlying issue, when possible, is better, as the problem ceases to exist.

For many people, the "underlying issue" is fundamentally just being too hungry for how they live. GLP-1s absolutely treat that.

Re: What Ozempic does to the gut-brain axis

#155

Post by hamhock666 »

paulddraper wrote: post #149
hamhock666 wrote: post #143

Earlier quoted context omitted.

If you can find a way to use your own free will and self-discipline to stop the bad condition then that seems preferable to using a drug. Maybe someone doesn't have the willpower in which case it's good that we have the drug. With regards to omeprazole, I changed my diet a bit and no longer needed the omeprazole. I don't know exactly what it was, but if you can get off of a drug because you don't need it anymore that…

I mean…that’s just like depression medication. It’s possible to ignore sadness as well as hunger.

There are usually ways to fix the problems in your life, like sadness and hunger, without resorting to using drugs. Maybe not everyone but it is something we should strive for.

Re: What Ozempic does to the gut-brain axis

#156

Post by crooked-v »

faangguyindia wrote: post #147
JumpCrisscross wrote: post #113

Earlier quoted context omitted.

> evidence of where their fat stores came from? Yes. Specifically, how basal metabolism is not a consciously-controlled rate that modifies itself against diet and exercise to the point that in some people with serious metabolic syndrome it may be impossible for them to lose weight through diet and exercise without suffering nutritional shortfalls. Also, the clinical evidence around what works for people losing weight…

>Yes. Specifically, how basal metabolism is not a consciously-controlled rate that modifies itself against diet and exercise to the point that in some people with serious metabolic syndrome it may be impossible for them to lose weight through diet and exercise without suffering nutritional shortfalls. The average person does not understand how weight loss works; many people do not know the concept of maintenance calo…

> Simply putting them on drugs for life isn't a solution.

Plenty of people are on drugs for life for a variety of things that have less health impact than being overweight.

Re: What Ozempic does to the gut-brain axis

#157

Post by cjbgkagh »

emmelaich wrote: post #146
cjbgkagh wrote: post #53

Earlier quoted context omitted.

This is why I took it, auto immune related ME/CFS. Works great. I still get PEM but outside of that I get to live a normal life.

Interesting! Is it possible that you're just eating less of whatever triggers the autoimmune symptoms?

No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.

Re: What Ozempic does to the gut-brain axis

#158

Post by faangguyindia »

crooked-v wrote: post #154
htk wrote: post #150

Earlier quoted context omitted.

No, the symptom is being treated, not the underlying issue. And that's ok, but treating the underlying issue, when possible, is better, as the problem ceases to exist.

For many people, the "underlying issue" is fundamentally just being too hungry for how they live. GLP-1s absolutely treat that.

for many people the underlying issue is serious lack of education when it comes to nutrition.

Not understanding calorie balance, not understanding calorie density of the food they eat.

How many people know 1kg fat = 7700kcal that if they could create deficit of 7700kcal they could potentially lose 1kg bodyfat? Ofc, i know the relationship isn't that simple but for most people this roughly holds true.

If you are eating granolas in breakfast, it may come across as a shock how many calories they pack, go ahead look it up many people believe that's a low calorie health breakfast option.

Many people don't know

1g of carb or protein = 4kcal

1g of fats = 9kcal.

Re: What Ozempic does to the gut-brain axis

#159

Post by ksenzee »

applfanboysbgon wrote: post #84
ceejayoz wrote: post #81

Earlier quoted context omitted.

> We also know there's a replication crisis in psychology and medicine… It seems unlikely to extend to bariatric surgery outcomes. > This idea that Americans are genetically pre-ordained to be fat seems like fanciful thinking. This idea that Americans are genetically pre-ordained to lack willpower seems like fanciful thinking.

Of course they aren't genetically pre-ordained to lack willpower. That's why they could stop being fat, if only they chose to. The issue is cultural, not genetic. You don't go from 12% obesity to 40% obesity in 40 years due to a genetic shift, but rather a cultural one.

What evidence do you have that it is a cultural shift, rather than, say, a chemical in the environment that wasn't there before, or a difference in the food supply?
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