Earlier quoted context omitted.
> What do you mean by 'any evidence that works better Than alternatives'? I mean exactly that, clinical trials demonstrating that proton therapy is superior to radiation therapy. This is not a question about the physics but about how patients respond (and whether the expense of delivering proton therapy outweighs the expected marginal benefits).
As a non expert, I can't pronounce myself on the subject, I found this recent study: https://www.mdanderson.org/newsroom/research-newsroom/proton... But on the subject of discoveries and practical uses, the IBA cyclotrons are also used for other purposes than proton therapy: cleaning exotic fruits from dangerous substances and personalized medicine.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
The study was designed to show non-inferiority, which doesn't preclude their ability to show an improvement. It would be helpful to see other studies before determining that proton therapy is better (or even non-inferior) to radiation therapy. It's certainly much more expensive, which shows up in the study as many subjects being denied insurance coverage.
Edit: This is now in the weeds, but the per-protocol participants didn't fare better than the intention-to-treat participants, which one might expect since insurance approval lead to dozens of subjects changing treatment arms.