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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#31

Post by OJFord »

bravesoul2 wrote: post #29
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

I also thought about epidural. Is that a non addictive way to give pain relief (extreme yes)

It is used surgically too (not just in childbirth as you might associate it) but it's a relatively risky procedure vs. a venous injection or pill to swallow.

Re: The first non-opoid painkiller

#32

Post by bravesoul2 »

echelon_musk wrote: post #14

> Traditional opioids mimic opium, a compound found in the poppy plant that contains morphine. Huh? How can a compound contain another compound. I thought opium was the term for an extract which contained opiates (compounds) and not the other way round.

This sentence confused me too!

Re: The first non-opoid painkiller

#33

Post by circlefavshape »

skerit wrote: post #27
bheadmaster wrote: post #21

Earlier quoted context omitted.

> even the "pain relief" provided by sticking a knife through your skin to the bone is addictive > the side effect of addiction isn't going to go away While I agree with your conclusion itself, I disagree that the premise implies the conclusion. The main difference between suzetrigine and opioids, as explained in the article: Crucially, opioids don’t just kill pain: they also incite pleasure. When the mu opioid recep…

What is this thread? Sticking a knife through your skin to the bone kills pain and is addictive?

+1! wtf!

Re: The first non-opoid painkiller

#34

Post by gorjusborg »

Snoozus wrote: post #5

This is clickbait, there are at least two classes of non opioid painkillers in use since a long time. https://en.wikipedia.org/wiki/Analgesic

I don't feel the title is misleading, but it may be a cultural language difference.

The term 'painkiller' is reserved for strong pain relief, and wouldn't include things like ibuprofen. That made me think immediately of a non-opioid pain blocker not just a pain reliever.

Re: The first non-opoid painkiller

#36

Post by nick__m »

skerit wrote: post #27
bheadmaster wrote: post #21

Earlier quoted context omitted.

> even the "pain relief" provided by sticking a knife through your skin to the bone is addictive > the side effect of addiction isn't going to go away While I agree with your conclusion itself, I disagree that the premise implies the conclusion. The main difference between suzetrigine and opioids, as explained in the article: Crucially, opioids don’t just kill pain: they also incite pleasure. When the mu opioid recep…

What is this thread? Sticking a knife through your skin to the bone kills pain and is addictive?

Some people pratice self-mutilation to relief their depression. 20 something years ago I frequented a girl who was full of scars under her clothes, she was pretty good at finding plausible excuses for the scars (plausible to a 20yr old ignorant about that practice), one day she confessed that she did this to herself and that she was unable to stop... It's not a memory I tought I would revisit but your question made me think of her and her dangerous mania.

Re: The first non-opoid painkiller

#37

Post by capitol_ »

skerit wrote: post #27
bheadmaster wrote: post #21

Earlier quoted context omitted.

> even the "pain relief" provided by sticking a knife through your skin to the bone is addictive > the side effect of addiction isn't going to go away While I agree with your conclusion itself, I disagree that the premise implies the conclusion. The main difference between suzetrigine and opioids, as explained in the article: Crucially, opioids don’t just kill pain: they also incite pleasure. When the mu opioid recep…

What is this thread? Sticking a knife through your skin to the bone kills pain and is addictive?

Maybe they should have said something along the line "replaces the pain with a new one and gives you adrenalin that surpresses it and is addictive"

Re: The first non-opoid painkiller

#38

Post by perching_aix »

> Another example involves nerve growth factor inhibitors like tanezumab. Although tanezumab alleviated inflammatory pain from conditions like osteoarthritis, Phase III trials revealed an unfortunate side effect: rapidly progressive osteoarthritis. Researchers hypothesized that because patients felt so much better, they overused their arthritic joints, accelerating damage. Although further trials were conducted at lower doses and with restrictions, the FDA ultimately voted against its approval.

Really not sure how to feel about this part lol, I mean I get it, but at the same time this is very ugh.

Re: The first non-opoid painkiller

#39

Post by mrob »

echelon_musk wrote: post #14

> Traditional opioids mimic opium, a compound found in the poppy plant that contains morphine. Huh? How can a compound contain another compound. I thought opium was the term for an extract which contained opiates (compounds) and not the other way round.

Two different meanings of the word. The article is using the traditional non-scientific meaning. Opium is a compound (as in a mixture), containing several different chemical compounds (as in molecules containing more than one element).

Re: The first non-opoid painkiller

#40

Post by billforsternz »

ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional visits to the US.
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