s/opoid/opioid/
The first non-opoid painkiller
11–20 of 235 posts
Re: The first non-opoid painkiller
#12Other comments have mentioned NSAIDs, but also there's nitrous oxide, ethanol, meditation, etc. This is a silly headline.
It should have "suitable for treating post-surgery pain" added to it - that qualification is in the body of the article.
Re: The first non-opoid painkiller
#13I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/
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Re: The first non-opoid painkiller
#14> Traditional opioids mimic opium, a compound found in the poppy plant that contains morphine.
Huh? How can a compound contain another compound. I thought opium was the term for an extract which contained opiates (compounds) and not the other way round.
Re: The first non-opoid painkiller
#15According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain.
Seams strange if this one truly will not have "drug abuse" connected to it.
Re: The first non-opoid painkiller
#16According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain. Seams strange if this one truly will not have "drug abuse" connected to it.
I am very curious about these theories, can you refer them?
Re: The first non-opoid painkiller
#17Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.
It will have different side effects.
Plus don't forget: even the "pain relief" provided by sticking a knife through your skin to the bone is addictive. So the side effect of addiction isn't going to go away.
Re: The first non-opoid painkiller
#18According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain. Seams strange if this one truly will not have "drug abuse" connected to it.
I am very curious about these theories, can you refer them?
Operant conditioning
https://en.wikipedia.org/wiki/Operant_conditioning
There are also lots of studies indicating that the speed of action of a drug is important for addiction. Which essentially boils down to the fact that the brain (beeing effected by operant conditioning) needs a drug response that is sufficiently noticeable to be connected to the action of taking the drug.
Re: The first non-opoid painkiller
#19According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain. Seams strange if this one truly will not have "drug abuse" connected to it.
The impression I got from Wikipedia reading about this (suzetrigine) is that it’s not addictive because it acts on peripheral nerves and not directly in your brain
Re: The first non-opoid painkiller
#20Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.
>It's the first non opioid painkiller applicable for situations like post operative use.
Perhaps the first approved by FDA, I don't know. In many countries, metamizole is the first-line drug for postoperative pain.
(It should be noted that metamizole may very rarely cause agranulocytosis. It is suspected that the risk varies depending on the genetic makeup of the population, which would explain why it is banned in some countries but available OTC in others.)