The first non-opoid painkiller
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The first non-opoid painkiller
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Re: The first non-opoid painkiller
#2Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects.
It's the first non opioid painkiller applicable for situations like post operative use.
I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.
Re: The first non-opoid painkiller
#3Interesting that the author chose that title despite the existence of NSAIDS [^1] and paracetamol(acetaminophen) - the latter of which they even mention (but only in the context of combination with opioids)
Did I miss something?
EDIT: answered in sibling post, thanks @ggm!
[1]: Non Steroidal Anti-Inflammatory Drugs
Re: The first non-opoid painkiller
#4Anyone better than me in pharmacology able to explain how suzetrigine compares to (high dosage?) ambroxol?
They are both Nav1.8 blockers, but in Germany you can get lots of ambroxol for cheap and OTC.
Re: The first non-opoid painkiller
#5This is clickbait, there are at least two classes of non opioid painkillers in use since a long time.
https://en.wikipedia.org/wiki/Analgesic
Re: The first non-opoid painkiller
#6The title... Confuses me. Especially with a handful on non-opiod painkillers sitting in my history. Gabapentin? Heck, ibuprofen?
Especially when the article itself compares it to ibuprofen:
> If paracetamol and ibuprofen are inadequate for pain relief, Journavx can now be prescribed as the next alternative treatment, instead of mild- to moderate-strength opioids.
"suitable for treating post-surgery pain" isn't something to cut, just for a better title. It just makes the clickbait stench of that first line even worse.
This is a better paracetamol. Which is awesome, and something we need. This is not a world first.
Re: The first non-opoid painkiller
#7Other comments have mentioned NSAIDs, but also there's nitrous oxide, ethanol, meditation, etc.
This is a silly headline.
Re: The first non-opoid painkiller
#8[flagged]
Re: The first non-opoid painkiller
#9I think a better title here than:
> The first non-opoid [sic] painkiller
might be:
> The first non-opioid nociceptive pain-killer
Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for.
Re: The first non-opoid painkiller
#10We'll have to see how this pans out, once people start getting it prescribed.
If you want to see what a "non-addictive" painkiller is like, watch Dopesick.