People using a CPAP - have you looked at Inspire? [1]. My pulmonologist friend highly recommends it. The device has very high success rate and is now in the 5th generation of development.
Sleep apnea pill shows striking success in large clinical trial
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Re: Sleep apnea pill shows striking success in large clinical trial
#82I must be in the minority of CPAP users who would use it even if I stopped having OSA. Why? A few reasons:
1. Sometimes I hardly notice it. Newer models are very quiet and portable. I'd even go as far as saying the mask is comfortable to wear, like a security blanket for the face.
2. Practically nothing filters out dust and cat hair better than my CPAP. An N95 mask might do better, but would be ridiculously uncomfortable by comparison.
3. It's a humidifier strapped to my face. No more discomfort trying to sleep through dry weather seasons.
Re: Sleep apnea pill shows striking success in large clinical trial
#83I've had problems with obstructive sleep apnea for a couple of years. Tried CPAP/BPAP for a month and hated it so much I'm now trying to see what I can fix with surgery even though surgeries like maxilofacial sound horrific. I currently have a MARPE device installed to slowly splitting my palate bone down the middle to expand that. A pill sounds wonderful..
I've been taking a B1 (thiamine) suplement before bed and it significantly reduces reports of snoring and apnea from my sleeping partner. I think my apnea is more central than obstructive though.
My observations are that I'm more likely to breathe through my nose when sleeping after taking B1, and that my nasal passages seem clearer, but I don't notice anything else (other than vitamin shop smell in urine).
A neighbor suggested B1, and while I couldn't find any quality research, it falls into my bucket of 'if it's not obviously harmful... If it's stupid and it works, it's not stupid' and a bottle of b1 supplements is inexpensive. You'll know after a couple nights if it's helpful for you.
I had a palette expander when I was young for orthodonic reasons. Fun times.
Re: Sleep apnea pill shows striking success in large clinical trial
#84I must be in the minority of CPAP users who would use it even if I stopped having OSA. Why? A few reasons: 1. Sometimes I hardly notice it. Newer models are very quiet and portable. I'd even go as far as saying the mask is comfortable to wear, like a security blanket for the face. 2. Practically nothing filters out dust and cat hair better than my CPAP. An N95 mask might do better, but would be ridiculously uncomfort…
4. There's some pretty powerful conditioning in associating it with sleep and it helps tell the brain it's time to shutdown for the night.
Re: Sleep apnea pill shows striking success in large clinical trial
#85There's also a new "KPAP" (KairosPAP) that is a different air delivery algorithm that people tend to find much more comfortable. Rather than being a constant air delivery, it's a little kick at just the right time, is my understanding. https://sleepdoctor.com/pages/cpap/kairospap-kpap
It does look interesting, especially for patients with a low arousal threshold (those who are easily disturbed or woken up from sleep). Unfortunately it isn't approved yet and isn't commercially available as a result.
Correct, but it also sounds like it might become available within the next year, though I did reach out to them and ask and received no response. It looks like the last updates on it were almost a year ago, so it makes me wonder if they've hit some kind of snag. They are planning on releasing their own hardware, but my ENT expects it may become available for many available "autoPAP" machines as a firmware upgrade.
Re: Sleep apnea pill shows striking success in large clinical trial
#86People using a CPAP - have you looked at Inspire? [1]. My pulmonologist friend highly recommends it. The device has very high success rate and is now in the 5th generation of development. https://www.inspiresleep.com/en-us/
Is it an implanted device? The website makes it really hard to find out how it is worn, or if it is surgically implanted.
Re: Sleep apnea pill shows striking success in large clinical trial
#87>One of the medications, atomoxetine, approved by the U.S. Food and Drug Administration (FDA) in 2002 for attention-deficit/hyperactivity disorder, increases levels of the excitatory neurotransmitter norepinephrine by blocking its reuptake from neuronal synapses.
Guessing this will never see the light of day as insomnia is going to be a major side effect. Preventing sleep apnea by preventing sleep is not exactly a great trade-off.
Re: Sleep apnea pill shows striking success in large clinical trial
#88Has anyone tried the "hostage tape" or similar to force breathing through your nose like Essential Craftsman discussed in his series of videos https://youtu.be/g8JzXEoT9LI?si=rVuZRoMrE_fwL0qv
I've tried them, but if you have facial hair they don't stick well and come off too easily. Instead, I've been using 3M micropore tape - just the right amount of adhesive, my skin feels fine, and cheap too. It works well to stop me breathing through my mouth.
What process do you use for taping, full mouth, full mouth with slits, "soul patch" strip in the middle?
Re: Sleep apnea pill shows striking success in large clinical trial
#89Has anyone tried the "hostage tape" or similar to force breathing through your nose like Essential Craftsman discussed in his series of videos https://youtu.be/g8JzXEoT9LI?si=rVuZRoMrE_fwL0qv
Seems really dangerous to block the airway. If you get a runny, bloody, stuffed or otherwise blocked nose, seems like you can suffer some bad outcomes.
Re: Sleep apnea pill shows striking success in large clinical trial
#90Earlier quoted context omitted.
Virtually any pill you have to take for life has negative side effects. Medicine made serious progress in all kind of ways but we don't have magic pills yet, even simple things like fixing a broken bone "only" has a 90-95% success rate without complications. Stay in shape, eat clean an exercise, once it's gone it's gone for good
This largely misses the point. While many people develop high blood pressure due to lifestyle choices, there's also a large amount of people who have high blood pressure for completely unrelated reasons. Staying fit and healthy is good, but it doesn't protect you against the genetic lottery.
Hypertension isn't a boolean flag, exercising and having a clean diet helps tremendously regardless.
50% of Americans have hypertension, 75% are overweight or obese, there is a massive overlap between the two