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Sleep apnea pill shows striking success in large clinical trial

science.org

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Re: Sleep apnea pill shows striking success in large clinical trial

#32
post #15

It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial. And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. S…

A drug that deals with physical obstruction??? Does it make a sleeper want to be on their side? Is it a weight loss drug? Targeted area antiinflammatory? Cavity dialation? For some snorers,bit would be an improvement based on that standard in my experience. Exercise staying fit. Not getting fat and not drinking alcohol work for me.

It happens to stimulate nerves in the airway such that it reduces collapse and obstruction.

PS: there are many people with OSA with normal BMI who also don't drink.

Re: Sleep apnea pill shows striking success in large clinical trial

#33
post #15

It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial. And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. S…

A drug that deals with physical obstruction??? Does it make a sleeper want to be on their side? Is it a weight loss drug? Targeted area antiinflammatory? Cavity dialation? For some snorers,bit would be an improvement based on that standard in my experience. Exercise staying fit. Not getting fat and not drinking alcohol work for me.

Glad it worked for you. Not everyone with sleep apnea is an overweight alcoholic. Plenty of drugs help with diseases involving muscle tone, why is that so surprising?

Re: Sleep apnea pill shows striking success in large clinical trial

#34
post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

Do you wear a cpap? It sucks. I have an OA now. And it also sucks.

I've been using CPAP for 10 years, and it's pretty much the best thing that ever happened to me!

The morning after my first real sleep in ~5 years was an unreal improvement. It felt like I was snatched from my death bed and back to normal.

I use the nostril mask, and it doesn't really bother me. The full face mask experience is a lot worse.

PS Technically, it blows!

Re: Sleep apnea pill shows striking success in large clinical trial

#35
There's also a new "KPAP" (KairosPAP) that is a different air delivery algorithm that people tend to find much more comfortable. Rather than being a constant air delivery, it's a little kick at just the right time, is my understanding. https://sleepdoctor.com/pages/cpap/kairospap-kpap

Re: Sleep apnea pill shows striking success in large clinical trial

#36
post #29

Earlier quoted context omitted.

My CPAP provides 3 massive life changing benefits: - a proper night's sleep - moisture that ensures I don't wake up with a massive sinus headache that destroys my morning - letting my partner have a proper night's sleep Any one of the 3 would be worth the minor inconveniences of a CPAP.

My CPAP does the first two. But generally if you get event the tiniest leak (and it's hard to stop all the leaks) it's very noisy for my partner. My masks leaks so little that I have between 0 and 1 events per hour but it's still annoyingly loud so my partner usually sleeps in our guest bedroom. If I could take a pill instead I would do so gladly. That being said my CPAP machine typically reduces events by 98% or so,…

Luckily my partner likes to sleep with a large fan; the noise of the CPAP blends well with that. But you're right about the leak noise -- about once a month I do get swatted in the middle of the night to adjust my mask.

Re: Sleep apnea pill shows striking success in large clinical trial

#37

Has anyone tried the "hostage tape" or similar to force breathing through your nose like Essential Craftsman discussed in his series of videos https://youtu.be/g8JzXEoT9LI?si=rVuZRoMrE_fwL0qv

I spoke with my ENT about this. I was treating anxiety triggered shortness of breath, and found that nose breathing was able to calm me if I box breathe.

She laughed, and said of course taping your mouth is stupid. Which I assumed, but had a friend of mine suggest it because it "changed his life". It's manosphere stuff.

Re: Sleep apnea pill shows striking success in large clinical trial

#38
post #15

It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial. And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. S…

A drug that deals with physical obstruction??? Does it make a sleeper want to be on their side? Is it a weight loss drug? Targeted area antiinflammatory? Cavity dialation? For some snorers,bit would be an improvement based on that standard in my experience. Exercise staying fit. Not getting fat and not drinking alcohol work for me.

Not every case of sleep apnea is obstructive. With central sleep apnea no amount of weight loss, surgery and repositioning will fix the problem.

Re: Sleep apnea pill shows striking success in large clinical trial

#39
post #3

>Atomoxetine also increases heart rate and diastolic blood pressure a little bit, I believe most people with Sleep Aonea tend to have High Blood Pressure, this could be concerning.

OSA causes high blood pressure; treating it could theoretically result in an overall reduction in blood pressure. If this gets approved, it would likely be at the provider's discretion. I imagine it won't get blindly prescribed to people with severe cardiac risk factors, but it may stop some from getting to that point.
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