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Sleep apnea pill shows striking success in large clinical trial

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Re: Sleep apnea pill shows striking success in large clinical trial

#41

Post by Citizen8396 »

linsomniac wrote: post #35

There's also a new "KPAP" (KairosPAP) that is a different air delivery algorithm that people tend to find much more comfortable. Rather than being a constant air delivery, it's a little kick at just the right time, is my understanding. https://sleepdoctor.com/pages/cpap/kairospap-kpap

It does look interesting, especially for patients with a low arousal threshold (those who are easily disturbed or woken up from sleep).

Unfortunately it isn't approved yet and isn't commercially available as a result.

Re: Sleep apnea pill shows striking success in large clinical trial

#42

Post by diggan »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

> That's ... unsettling. So you're reducing events at the cost of increased blood pressure and heart rate? That's not good.

Ultimately, the question becomes "is higher quality of sleep with some tradeoffs more or less healthy overall, than not getting enough sleep at all?", as research keeps showing how important sleep is. So even if this increases heart rate and diastolic blood pressure, does it raise it more than a couple of decades of not being able to sleep would do?

Re: Sleep apnea pill shows striking success in large clinical trial

#43

Post by [deleted] »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

[deleted]

Re: Sleep apnea pill shows striking success in large clinical trial

#44

Post by Citizen8396 »

binoct wrote: post #30
elric wrote: post #14

Earlier quoted context omitted.

> also on my relationship with my partner That's not really much of an issue. There's an adjustment period, and there's a bit of an art to finding an appropriate mask. One that fits perfectly fine for you might have an exhaust port that blows air in your partner's face. Or the one that your partner can't hear at all might sound thunderously loud in your ears. But all in all, your partner would much rather have you sl…

Those who can tolerate the general CPAP experience, have bed partners who tolerate it, and don’t experience detrimental effects should absolutely use it when there are no comparable solutions. However there are lots of perfectly legitimate reasons why not everyone can, and having alternatives (which do also come with side effects) to consider is amazing for the community overall. It’s legitimately great that it sound…

You nailed it. CPAP ultimately fails for something like 50% of patients.

Re: Sleep apnea pill shows striking success in large clinical trial

#45

Post by seattle_spring »

balls187 wrote: post #10
elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

Do you wear a cpap? It sucks. I have an OA now. And it also sucks.

I use one, and I love it. I'd probably continue to use it (or something like it) even if my apnea was cured. Breathing purified, warmed, perfectly humidified air piped directly to my nose is wonderful.

Re: Sleep apnea pill shows striking success in large clinical trial

#46

Post by aziaziazi »

bryanlarsen wrote: post #21
balls187 wrote: post #10

Earlier quoted context omitted.

Do you wear a cpap? It sucks. I have an OA now. And it also sucks.

My CPAP provides 3 massive life changing benefits: - a proper night's sleep - moisture that ensures I don't wake up with a massive sinus headache that destroys my morning - letting my partner have a proper night's sleep Any one of the 3 would be worth the minor inconveniences of a CPAP.

> letting my partner have a proper night's sleep

I’m interested in this: how’s the CPAP noise perceived by the partners?

I don’t snore and usually wake up quickly when doing the "apnea noise", stopping before waking her up. In the meantime I read that CPAP produce a a constant sound + an inconstant sound from the air coming in and out. She needs quietness to sleep and disturbing her sleep refrained me to try it out. Non trivial price is also a factor through, otherwise I would have tried it since a long time.

Re: Sleep apnea pill shows striking success in large clinical trial

#47

Post by GordonS »

linsomniac wrote: post #31

Has anyone tried the "hostage tape" or similar to force breathing through your nose like Essential Craftsman discussed in his series of videos https://youtu.be/g8JzXEoT9LI?si=rVuZRoMrE_fwL0qv

I've tried them, but if you have facial hair they don't stick well and come off too easily. Instead, I've been using 3M micropore tape - just the right amount of adhesive, my skin feels fine, and cheap too.

It works well to stop me breathing through my mouth.

Re: Sleep apnea pill shows striking success in large clinical trial

#48

Post by AStonesThrow »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

CPAP wouldn’t have such a bad rep if George Lucas hadn’t released Star Wars.

Anyone under 60 who hears heavy mechanical breathing expects someone to get choked in the next 5 minutes.

Re: Sleep apnea pill shows striking success in large clinical trial

#49

Post by spanktheuser »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

>>Can these 22% be identified based on some criteria?

Usually the preferred approach in cases like this is to trial the medication and revert back to the prior treatment plan if symptoms worsen. Obviously, this is only viable if the worst-case negative outcome is temporary, easily reversible, and not life threatening.

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