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High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

medicalxpress.com

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Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#21

Post by vlovich123 »

chasebank wrote: post #17

I remember reading about how the current recommended dose of Vitamin D was a statistical error in a study and has since been corrected to the tune of 10-11x higher. "The recommended daily intake of vitamin D has a long history, originally set at 400 IU/day in the early-to-mid 20th century, including the 1970s, primarily to prevent rickets in children and bone disease in adults. In 2010, the Institute of Medicine (IOM…

I thought follow up work also showed it's questionable whether dietary vitamin D actually has any of the benefits that you get through solar vitamin D?

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#22

Post by nbk_2000 »

tuesdaynight wrote: post #5

I got a prescription for vitamin D deficiency and started researching about it. On the way, I found the Coimbra Protocol[1], which evolves around giving high doses of vitamin D (40000-200000 IU) to multiple sclerosis patients. [1]: https://www.coimbraprotocol.com/the-protocol-1

Same here, and with good results, but a note of warning, according to my doctor 10,000 - 20,000 are considered in the protocol a normal daily supplement for adults with vitamin D issues. Dosages above that require medical supervision (in the form of regular blood and urine analysis). Also at those high doses there are potential negative side effects that must be mitigated (osteoporosis being among them). So please don't just YOLO massive doses of vitamin D.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#23

Post by trevorkoob »

SOLAR_FIELDS wrote: post #10
saos wrote: post #7

I’ve been toying with idea of upping vitamin D Iu. Currently its 1000 and that was what was prescribed to me a while back.

I take 5000 daily as a maintenance dose. Bloodwork has been basically perfect since I started doing that. If you are deficient doctors often prescribe a massive daily dose like 20000-30000 to get back to normal then drop down to a maintenance dose. The nice thing with vitamin D is that you can actually check its level in bloodwork. The normal range is often considered to be between 50-125 ng/mL with below 30 consider…

Adding on this point, in my research I found blood serum testing to be wildly imprecise.

The conclusion of my study was that we should do more studies where we take regular blood level samples and adjust dosage to achieve a certain average level (near the upper level of the range).

5000IU D3 (D2 is about 1/3-1/2 as effective at raising blood serum levels) is a good starting point.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#24

Post by johnisgood »

ohmyiv wrote: post #18
adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

When does a professional come into play? You assumed you're deficient, you asked chatgpt, and now you're asking for anecdotes from HN. Go get some blood work done and talk to a professional who actually knows about these things.

> talk to a professional who actually knows about these things

And gives a damn, and is up to date. Difficult to find professionals like that around here, even with money.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#25

Post by trevorkoob »

armedpacifist wrote: post #9

On a sidenote, for everyone looking into vit d, this talk with Stasha Gominak was very informative: https://www.youtube.com/watch?v=74F22bjBmqE As for the criticism against vit d supplements because of the extreme variability of actual vit d between brands, regardless of the supposed IU they advertise (there is very little objective, independent quality control being done, which makes it a bit of a wild west, but I g…

Other than the value you are aiming for (I personally aim for the upper edge of the normal range), I agree with the immense variability in dosage, and also would like to mention imprecision in vitamin D bloodwork tests as well.

Thankfully throughout my Vitamin D research, I found low risk of overdose, and cases of immense accidental overdose that appear to have been treated successfully (mainly by stopping the over-intake).

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#26

Post by JumpCrisscross »

armedpacifist wrote: post #9

On a sidenote, for everyone looking into vit d, this talk with Stasha Gominak was very informative: https://www.youtube.com/watch?v=74F22bjBmqE As for the criticism against vit d supplements because of the extreme variability of actual vit d between brands, regardless of the supposed IU they advertise (there is very little objective, independent quality control being done, which makes it a bit of a wild west, but I g…

> Get your bloodwork checked again after a month and proceed from there

As someone who's had a vitamin D deficiency, your serum vitamin d levels will almost certainly vary month to month as a result of the weather.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#27

Post by nostrebored »

vlovich123 wrote: post #21
chasebank wrote: post #17

I remember reading about how the current recommended dose of Vitamin D was a statistical error in a study and has since been corrected to the tune of 10-11x higher. "The recommended daily intake of vitamin D has a long history, originally set at 400 IU/day in the early-to-mid 20th century, including the 1970s, primarily to prevent rickets in children and bone disease in adults. In 2010, the Institute of Medicine (IOM…

I thought follow up work also showed it's questionable whether dietary vitamin D actually has any of the benefits that you get through solar vitamin D?

Yes, 90% of the world’s population does not absorb dietary vitamin D well, which should make people skeptical of this result.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#28

Post by justinko »

adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Always take magnesium with vit D. Ask an LLM why.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#29

Post by Sunspark »

vitanxiety wrote: post #20
adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Not sure why you're being downvoted, so I created an account specifically to respond. I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but…

Out of curiosity, the various brands, were any of them in liquid form?

The reason I ask is because it's possible to be intolerant or allergic to one of the filler ingredients in a tablet.

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