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High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

medicalxpress.com

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Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#11

Post by jajko »

adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

1000 ui per day? Thats a small dose, I am myself taking 800 per day but when I skip I just compound it for next dose since D works this way and accumulates, not like vitamin C. I had bad case of deficiency recently (when finally some blood work was done) and initial treatment to jumpstart was IIRC 100k ui.

Maybe you have some sort of sensitivity to medium in which its dissolved?

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#12

Post by j_w »

VladVladikoff wrote: post #4

I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be. I can’t find the article which caused me to originally start my 7500 IU regiment but there…

The linked study uses a daily dose of 6,000IU, and references two studies (13,26) which also tout the benefit of supplementing Vitamin D at a 3,000IU dose and a 3,332IU dose, both daily.

The two studies which are referenced (27,28) that do not find any significant benefits followed a different dosing strategy: 20,000IU and 60,000IU, weekly.

It seems like daily, large doses is the best method for supplementing vitamin D. I've seen it suggested to pair vitamin D supplementation with calcium and magnesium [1].

[^1]: https://pubmed.ncbi.nlm.nih.gov/32972636/

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#13

Post by adamgordonbell »

bruce343434 wrote: post #8
adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

I don't think there's an easy answer as we all have differently tuned bodies with different known/unknown beningn/malevolent conditions. It's probably good to do some short term experimenting, try eating more magnesium and calcium rich foods and see how you feel. If you really want to be objective, get your blood contents measured. (Although blood levels don't show everything, like calcium stores in the bones.)

Yeah, experimentation makes sense.

I've had it happen twice, with two different dosages. First time was at a higher dosage than 1000 and I think it happened sooner.

I'm just calling it out here, because sometimes you get lucky and someone else had the same issue and has the answer and will resolve the mystery.

I'm not saying Vit D is bad, I'm just curious if others have had difficulties with it.

My doctors opinion on it is everyone is low on Vit D, so just take some.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#14

Post by Tade0 »

VladVladikoff wrote: post #4

I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be. I can’t find the article which caused me to originally start my 7500 IU regiment but there…

> I’ve personally been taking 7500 IU daily for many years now.

And here I am debating whether increasing to 4000 was pushing my luck. I am also reporting less illnesses - or actually - no instances of being bedridden, which is an improvement over the previous flu seasons.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#15

Post by y33t »

SOLAR_FIELDS wrote: post #10
saos wrote: post #7

I’ve been toying with idea of upping vitamin D Iu. Currently its 1000 and that was what was prescribed to me a while back.

I take 5000 daily as a maintenance dose. Bloodwork has been basically perfect since I started doing that. If you are deficient doctors often prescribe a massive daily dose like 20000-30000 to get back to normal then drop down to a maintenance dose. The nice thing with vitamin D is that you can actually check its level in bloodwork. The normal range is often considered to be between 50-125 ng/mL with below 30 consider…

Vitamin D deficiency has also been linked to cancer, specifically colorectal IIRC. Also people who had D deficiency were more likely to have problems with COVID.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#16

Post by FollowingTheDao »

adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

I don’t know why you’re being downloaded.

I took 5000 IU of vitamin D for one month and I just happen to have a blood test that was coming up. My calcium levels were elevated. I was told to take this dose by my doctor, because my vitamin D levels, not deficient she felt they were very low.

During this time, my mood also worsened.

Some of us may be more sensitive to calcium transport when taking vitamin D than others, and this is clearly due to genetics. Interestingly enough, there is something in fish which controls this, I can’t think of it off the top of my head right now, but I will look it up and post it later.

So now I only get my vitamin D from natural occurring vitamin D in seafood, and the sun.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#17

Post by chasebank »

I remember reading about how the current recommended dose of Vitamin D was a statistical error in a study and has since been corrected to the tune of 10-11x higher.

"The recommended daily intake of vitamin D has a long history, originally set at 400 IU/day in the early-to-mid 20th century, including the 1970s, primarily to prevent rickets in children and bone disease in adults. In 2010, the Institute of Medicine (IOM) updated the recommendation to 600 IU/day for most adults and 800 IU/day for those over 70. However, a major statistical error in the IOM’s analysis was later uncovered by researchers, who showed that the calculation underestimated the amount needed to achieve sufficient blood levels of vitamin D in 97.5% of the population. Their corrected analysis suggested a required intake closer to 7,000 IU/day, an order of magnitude higher. Despite this, most official health organizations have not revised the RDA, and the 600–800 IU/day guideline remains standard." [chatgpt summary]

https://www.grassrootshealth.net/blog/iom-miscalculated-rda-...

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#18

Post by ohmyiv »

adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

When does a professional come into play? You assumed you're deficient, you asked chatgpt, and now you're asking for anecdotes from HN. Go get some blood work done and talk to a professional who actually knows about these things.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#19

Post by trevorkoob »

VladVladikoff wrote: post #4

I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be. I can’t find the article which caused me to originally start my 7500 IU regiment but there…

Did a masters on Vit D.

Multiple overdoses of over 1 million IU have been recovered from without obvious long-term damage present in near term follow up.

Out of vitamin D’s many potentially clinically positive effects some of the clearest and best evidence is for increased muscle strength.

Personally I take between 5000-10000 IU D3 daily depending on exposure to sun intensity.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#20

Post by vitanxiety »

adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Not sure why you're being downvoted, so I created an account specifically to respond.

I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but who knows. If you search this symptom online, you'll find a lot of people with the same reaction but never any explanation.

Definitely interested to see if anyone has had this same issue and was able to fix it.

Anyway, just a word of caution to anyone reading. Because even 400iu makes me feel very uncomfortable. I don't want to know what would happen at 4,000iu.

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