High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
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Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#2Question to HN: To what extent do we understand vitamin D's activity in our body?
A lot of the focus seems to be on the bone, muscle, teeth, etc. components, but I also hear often about headlines like in the OP or its significance in improving mood. I would like to know if there's potential that we know little about its complete set of effects.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#3Question to HN: To what extent do we understand vitamin D's activity in our body? A lot of the focus seems to be on the bone, muscle, teeth, etc. components, but I also hear often about headlines like in the OP or its significance in improving mood. I would like to know if there's potential that we know little about its complete set of effects.
https://examine.com/supplements/vitamin-d/
This is a good place to get that kind of information
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#4I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be.
I can’t find the article which caused me to originally start my 7500 IU regiment but there are many similar papers out now, such as:
>Soccer players that supplemented with 6,000 IU of vitamin D significantly improved their blood vitamin D levels, increased their free and total testosterone, and performed better on the 5 m sprint test compared to the placebo group. https://pmc.ncbi.nlm.nih.gov/articles/PMC7284423/
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#5I got a prescription for vitamin D deficiency and started researching about it. On the way, I found the Coimbra Protocol[1], which evolves around giving high doses of vitamin D (40000-200000 IU) to multiple sclerosis patients.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#6I've tried taking vitamin D bc heard it was so great.
After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping.
I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect.
Anyone have an answer? I assume I'm deficient but I'm not sure its worth the benefits.
( I'm not saying Vit D is bad, I'm just curious if others have had difficulties with it )
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#7I’ve been toying with idea of upping vitamin D Iu. Currently its 1000 and that was what was prescribed to me a while back.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#8I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…
I don't think there's an easy answer as we all have differently tuned bodies with different known/unknown beningn/malevolent conditions. It's probably good to do some short term experimenting, try eating more magnesium and calcium rich foods and see how you feel. If you really want to be objective, get your blood contents measured. (Although blood levels don't show everything, like calcium stores in the bones.)
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#9On a sidenote, for everyone looking into vit d, this talk with Stasha Gominak was very informative: https://www.youtube.com/watch?v=74F22bjBmqE
As for the criticism against vit d supplements because of the extreme variability of actual vit d between brands, regardless of the supposed IU they advertise (there is very little objective, independent quality control being done, which makes it a bit of a wild west, but I guess that goes for _all_ supplements).
I don't think it's necessarily a problem. Ignore the prescribed dosage by the brand. This sounds like bad advice, but it's not reliable cfr. the variability. Just get your bloodwork done first. Then start experimenting with consistent dosages and stick to one brand. Get your bloodwork checked again after a month and proceed from there. Aim at a value between 40 and 70 (according to Gominak, which I concur doing my own research/experimenting).
Disclaimer: I am not a doctor, please do your own research and preferably consult with a medical advisor
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#10I’ve been toying with idea of upping vitamin D Iu. Currently its 1000 and that was what was prescribed to me a while back.
I take 5000 daily as a maintenance dose. Bloodwork has been basically perfect since I started doing that. If you are deficient doctors often prescribe a massive daily dose like 20000-30000 to get back to normal then drop down to a maintenance dose.
The nice thing with vitamin D is that you can actually check its level in bloodwork. The normal range is often considered to be between 50-125 ng/mL with below 30 considered deficient and above 120 or so considered too much.
I highly recommend people stay on top of this particular vitamin. In addition to evidence that a deficiency significantly affects your immune system functionality, it’s also uncomfortable. My spouse has been deficient in the past and experienced hand cramps, back spasms, muscle aches etc.
It’s fat soluble so it takes a few weeks to get it back to normal after supplementation