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Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

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Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#61

Earlier quoted context omitted.

Autism plus "AI for social" coprocessor could be a wicked combo ;)

I know several autistic adults who check their outgoing messages with AI for unintentional meanings or recommendations to better communicate what they mean. Not getting the ai to write for them mind you. Social coprocessor indeed!

I know non-austistic adults that ask ChatGPT to rewrite their messages so they land better. Take the nasty unproductive letter you want to send to your partner that you're currently fighting with, then have ChatGPT soften the accusations so the reader doesn't immediately become defensive and doesn't read the rest of the letter so the two of you can have a productive conversation.

Cheaper than couples counseling!

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#62
post #49

Earlier quoted context omitted.

Fitness function? What if end up walking down the eugenics path or genetic engineering.

Society took the biggest of bats and beat the ever loving love out of the fitness function in many parts of the world.

Fitness functions are retrospective, so there is no "We should have done this differently."

The definition of fitness is literally whatever persists by reproduction.

Features and species that persist for a while and then collapse/disappear are a normal part of the process.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#63
post #59

Earlier quoted context omitted.

> when you get asked why you did apply. What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all. Much of this stuff is just cultural anyway. There are Western societies where being "blunt and fra…

> What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all. Yes, and that's exactly what's confusing to people like me who have autism; the question being asked isn't actually the question that th…

I think I've made the case above that it's not merely about "being neurotypical", it's also about being steeped in a very specific culture. That peculiar use of "why did you apply" might as well be described as an idiomatic expression, a play on words that happens to be common in that well-defined context. If you aren't familiar with that usage because you are from a different cultural context (or even something as simple as a different "low-class" socio-economic stratum in the same society), you might misunderstand the question in the exact same way - or perhaps you'll grok it but you'll still be bothered by the implied "dishonesty" in it and be inclined to subvert expectations by starting with a straight and to the point answer, and then getting into the actual topic of why you think you were right to apply.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#64

Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. So I immediately looked at the preprocessing steps in the methods...which is, annoyingly, in supplemental 1. A few comments: It is written so vaguely, it is difficult to understand what preprocessing steps were done and in which order (which matters). The steps…

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Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#65
post #56

Earlier quoted context omitted.

Yeah, at least in my experience as someone autistic, I sometimes joke that everybody else got together and decided on a bunch of rules for how everyone needs to talk to each other going forward, but somehow my invite got lost and I missed my chance to learn them. I don't pretend to have any idea if things would be better or worse for society as a whole if everybody did things the way that would seem more natural to m…

Is it the majority? For me its always the moral guardian type of person, and they are definitely not the majority.

I'm honestly not quite sure what you mean here (which I guess is fitting given the topic of conversation!). In case what I was talking about might have unclear, when I talk about feeling like the majority of people are different than me, I'm saying the idea of social norms being communicated implicitly, or at least being something most people seem to be able to infer from previous examples. To use the example of the interview given above, someone might be able to explain to me that when I'm asked that question, I shouldn't treat it as literal and instead given an answer that fits the expectation they'll actually have, but if the interview instead asks a slightly different question like "what's one thing you would change about your current job?", someone like me might not realize that this is _also_ not a question where it's good to give an answer like "I wish I got paid more for doing less work". For me, it's impossible to take all of the norms and expectations that I've learned over the years and apply them to an entirely new situation that I'm not familiar with, and that's not something that most people seem to struggle with as much as me.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#66
post #59

Earlier quoted context omitted.

> What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all. Yes, and that's exactly what's confusing to people like me who have autism; the question being asked isn't actually the question that th…

I think I've made the case above that it's not merely about "being neurotypical", it's also about being steeped in a very specific culture. That peculiar use of "why did you apply" might as well be described as an idiomatic expression, a play on words that happens to be common in that well-defined context. If you aren't familiar with that usage because you are from a different cultural context (or even something as s…

My point isn't that neurotypical people will always be familiar with whatever idioms they encounter, but that learning those idioms is way easier for them. It seems like you're misunderstanding what I'm saying as the struggles of not understanding specific things as being specific to autistic people, and that's not the case; I'm saying that while neurotypical people might have to deal with specific cases of idioms or figures of speech, autistic people will often struggle with the meta-problem of struggling with idioms or figures of speech as an entire category rather than with not being familiar with individual ones. I don't just struggle with understanding language like that when dealing with people who come from a different background than me; I struggle to understand language like that when talking to my parents and my brothers and my wife, despite having talked with them more than anyone else in my life. That's not something that most people would struggle with, but it's something that I suspect a lot of autistic people would relate to.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#67
post #65

Earlier quoted context omitted.

Is it the majority? For me its always the moral guardian type of person, and they are definitely not the majority.

I'm honestly not quite sure what you mean here (which I guess is fitting given the topic of conversation!). In case what I was talking about might have unclear, when I talk about feeling like the majority of people are different than me, I'm saying the idea of social norms being communicated implicitly, or at least being something most people seem to be able to infer from previous examples. To use the example of the…

> "I wish I got paid more for doing less work"

The socially acceptable way to say exactly that is something like "I wish I was enabled to be more productive and accomplish more with the same amount of effort." It's implied that you'd also want to be paid more as a consequence, since that's what everyone wants at the end of the day. The general rule, to the extent that there is any, is "try to be helpful to the interviewer and be cautious if it looks like you might be stating the obvious!".

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#68

I wonder how that ties into the hyperconnectivity induced by various psychoactive substances like psilocybin. All the research about GABA and glutamate seems too low level to me and not specific enough for treatment targets. Somewhat like using body weight to determine that disease.

I’d suggest tracing a line through the points of published research on autism, hyperthermia and its effects on autism spectrum related behaviors, the effect of Interleukin-17 thereon, the relationship from between IL-17 and Th17 helper cells, and the 5-HT2A receptor’s effects on Th17 cell regulation. And other stuff. Like thermoregulation. There’s more interesting stuff on the way and at every point. To manage expect…

does hyperthermia affect fungal infections? https://pmc.ncbi.nlm.nih.gov/articles/PMC7572136/

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#69
I am not an expert in any way, shape or form but I wonder how this squares with this other journal article in Nature: Molecular Psychiatry which came out in 2024? "11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults" https://doi.org/10.1038/s41380-024-02776-2

Edited to add title of the article

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#70

Earlier quoted context omitted.

I’d suggest tracing a line through the points of published research on autism, hyperthermia and its effects on autism spectrum related behaviors, the effect of Interleukin-17 thereon, the relationship from between IL-17 and Th17 helper cells, and the 5-HT2A receptor’s effects on Th17 cell regulation. And other stuff. Like thermoregulation. There’s more interesting stuff on the way and at every point. To manage expect…

does hyperthermia affect fungal infections? https://pmc.ncbi.nlm.nih.gov/articles/PMC7572136/

or vice versa, I have no idea!

I do recall reading that certain autoimmune disorders like psoriasis which are therapeutically impacted by serotonin receptors’ effects on the immune system do happen to increase susceptibility to fungal infection

iirc/afaik

before readings: that paper is wild

(I’ll approach it with a grain of salt while also not immediately discounting it)

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