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Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

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Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#51

Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. So I immediately looked at the preprocessing steps in the methods...which is, annoyingly, in supplemental 1. A few comments: It is written so vaguely, it is difficult to understand what preprocessing steps were done and in which order (which matters). The steps…

Is it too bold to say that any 10+ year old study claiming to have found across-subject brain x behavior relationship is not worth looking at closely?

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#52
post #2

What if growing bigger, more connected brains is the next evolutionary step? Doesn't seem entirely unreasonable to me.

As someone else pointed out: more isn't better. There's an optimum, and it depends on the task. There are some "in vivo" studies about connections in the young cat's visual cortex. It starts out very connected, and most of the connectivity is lost, while structures form.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#53
post #44

Earlier quoted context omitted.

The double empathy problem explains why it may not be a deficiency, just a "different brain language" between ND and NT people. Basically, from autistic perspective, it's the non autistic people who have deficiencies in communication. There's been a whole lot of research about that in the last 10-15 years or so. And a lot of memes in the community.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

> when you get asked why you did apply.

What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all.

Much of this stuff is just cultural anyway. There are Western societies where being "blunt and frank" like that is quite accepted or even expected, unlike the U.S. and the Anglosphere more generally.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#54
I wonder how that ties into the hyperconnectivity induced by various psychoactive substances like psilocybin.

All the research about GABA and glutamate seems too low level to me and not specific enough for treatment targets. Somewhat like using body weight to determine that disease.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#55

I wonder how that ties into the hyperconnectivity induced by various psychoactive substances like psilocybin. All the research about GABA and glutamate seems too low level to me and not specific enough for treatment targets. Somewhat like using body weight to determine that disease.

I’d suggest tracing a line through the points of published research on autism, hyperthermia and its effects on autism spectrum related behaviors, the effect of Interleukin-17 thereon, the relationship from between IL-17 and Th17 helper cells, and the 5-HT2A receptor’s effects on Th17 cell regulation. And other stuff. Like thermoregulation. There’s more interesting stuff on the way and at every point.

To manage expectations: It’s… an imaginary line?

—- edit: on the run, hope to be able to follow up with papers

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#56
post #44

Earlier quoted context omitted.

The double empathy problem explains why it may not be a deficiency, just a "different brain language" between ND and NT people. Basically, from autistic perspective, it's the non autistic people who have deficiencies in communication. There's been a whole lot of research about that in the last 10-15 years or so. And a lot of memes in the community.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

Yeah, at least in my experience as someone autistic, I sometimes joke that everybody else got together and decided on a bunch of rules for how everyone needs to talk to each other going forward, but somehow my invite got lost and I missed my chance to learn them. I don't pretend to have any idea if things would be better or worse for society as a whole if everybody did things the way that would seem more natural to me, but it does seem pretty likely to me that neurotypical people would probably struggle in a lot of the ways I often do.

In a certain sense, this makes the experience of being autistic more frustrating. If there were some definitive flaw someone could point to in my brain that would make communication difficult for me regardless of social norms, that might be easier to come to terms with; the feeling that I'm not actually struggling due to any actual issue other than not being in the majority makes it hard not to feel resentful sometimes though. That being said, it's so hard to conceive of a clean separation between the parts of my personality that I do like and the parts that make me struggle to communicate in a neurotypical fashion that if there were a magic switch I could flip to make me like everyone else (whatever that would mean), I still don't think I'd do it. At the end of the day, it's part of what makes me who I am, and I wouldn't recognize who I'd become without it.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#57
post #56

Earlier quoted context omitted.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

Yeah, at least in my experience as someone autistic, I sometimes joke that everybody else got together and decided on a bunch of rules for how everyone needs to talk to each other going forward, but somehow my invite got lost and I missed my chance to learn them. I don't pretend to have any idea if things would be better or worse for society as a whole if everybody did things the way that would seem more natural to m…

Is it the majority? For me its always the moral guardian type of person, and they are definitely not the majority.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#58
post #12

Earlier quoted context omitted.

This is like assuming that cancer is good? More cells, better body? This is just a hypothetical counter-argument. More connectivity could be better, "more intelligent", and autism seems to be "cool" among nerds for this reason. But maybe it's just a fallacy, just a way to pretend to be something better. Again, all hypothetical. Yesterday I listened to a podcast episode about bird brains [0]. That some birds have a wa…

Autism plus "AI for social" coprocessor could be a wicked combo ;)

AKA a wife (or other life partner)

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#59

Earlier quoted context omitted.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

> when you get asked why you did apply. What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all. Much of this stuff is just cultural anyway. There are Western societies where being "blunt and fra…

> What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all.

Yes, and that's exactly what's confusing to people like me who have autism; the question being asked isn't actually the question that they're looking for the answer to, and it's up to us to figure out what they actually mean. In this context, it might seem obvious to someone neurotypical, but I don't think I can easily articulate just how common this type of thing happens on a regular basis. The problem for me is that while I might understand what to do in this circumstance due to having encountered it before, it feels impossible to extrapolate what people mean when I'm in a new situation that I haven't had a chance to learn the "rules" for yet. I'm not exaggerating when I say that I've had to separately learn what the expected norms are for pretty much every circumstance I've ever encountered when people say one thing but assume that it's clear that they mean something different.

The fact that most of this stuff is cultural doesn't really change the fact that implicitly learning rules like this is something that most people don't struggle with to the extent that people with autism do. To me, the issue isn't that I specifically want people to be "blunt and frank" or not, but that no one directly communicates what the expectations are, and that it's not as simple as a binary of whether to be blunt or not. Most people might struggle if they suddenly found themselves in a culture where the expectations were different than they were used to, but they probably didn't struggle to learn the expectations of their own culture. For me, learning the expectations of the culture I've spent my entire life in is still an ongoing process after over three decades, and I don't expect that it will ever really be complete.

An culture of all autistic people wouldn't be identifiable merely by how blunt they are, but by the giant binder they give everyone who comes to visit with all of the expectations written out to avoid any confusion. The reason I struggle with communication every day of my life is because I never got that binder, but everyone else seems to already have it memorized.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#60

Earlier quoted context omitted.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

> when you get asked why you did apply. What they're really asking, translated to "blunt and frank communication" mode is: "Why should we even care that you applied?" Then saying "hey, I need money for blah whatever" is non-responsive, but you can just talk about why you think you might be a good fit for them after all. Much of this stuff is just cultural anyway. There are Western societies where being "blunt and fra…

Lmao, then ask ”Why should we even care?”. I will filter people who lie or can put things straight regardless which side of the interviewing table I am sat.
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