What happened to self-control?
If you got it, use it. If you don't got it, there's a little help now.
How long til we're all on Ozempic?
491–500 of 1001 posts
Re: How long til we're all on Ozempic?
#492Earlier quoted context omitted.
And apparently the pure manufacturing cost for Ozempic is relatively low: > the active drug in Ozempic can be produced for about 29 cents for a month’s supply, or 7.2 cents for a typical weekly dose, the research found. It’s not cheap to make — semaglutide costs over $70,000 per kilogram. But only a tiny quantity of the drug is used in each weekly dose. > https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nor..…
By chance I just talked to someone with deeper knowledge on this and they said the current constraint is actually ramping up supply of the delivery mechanism, not the drug. I have zero expertise on this, but would be curious if anyone knows what's special about Ozempic delivery that can't be served by a commodity syringe.
> but would be curious if anyone knows what's special about Ozempic delivery that can't be served by a commodity syringe.
They can't charge as much. That's basically it. Generic semaglutide from compounding pharmacies (which have their own issues for sure) is under $150 a month cash-pay these days.
The real issue with syringes and self administration is that the vast majority of the population are not comfortable with it and don't have the diligence to do it correctly every time, so you get under/over dosage or noncompliance.
That being said, the autoinjector format doesn't really solve that problem, it just slightly ameliorates it, in exchange for approximately 8x the cost.
Re: How long til we're all on Ozempic?
#493Earlier quoted context omitted.
Is the official recommendation that you continue to take it for the rest of your life? Or, is there a schedule to "wean" people off of it?
Studies have show most people rapidly regain the weight once they stop taking GLP-1 drugs. The dysfunctional biochemical processes that contributed to overeating are still present if you discontinue the drug. Your body has a natural set-point for the weight it wants to be at, and the hunger and food noise comes right back as your body tries to get you back to your old weight. It's possible that after after a long eno…
> It's possible that after after a long enough time at a healthy weight your body's natural weight set-point will regulate itself back down. But this process take years.
I've spent a fair amount of time pursuing obesity research and I've never seen that. The closest I've seen is researchers or studies mentioning "Maybe the set-point resets are x years" but never seen any direct evidence of this.
Re: How long til we're all on Ozempic?
#494Living a healthy lifestyle, so that you won't need Ozempic, is possible - even surrounded by all the drugs and booze and carbs. I do it. Lots of people do it. The information is freely available, now more than ever. From all I've read, Ozempic isn't a silver bullet, and has many side effects. It just helps people stave off the inevitable for a while.
Well good for you, aren't you special...
Now what about the other 74% of the population.
You ever hear the saying "If you owe the bank $1000 dollars, that's your problem. If you owe the bank a million it's theirs"
This is a public health epidemic and no matter how much you scream "But I'm special" the rest of the world is going to fall apart around you. And yes, this issue is spreading to the entire world and not just the US.
Re: How long til we're all on Ozempic?
#495Earlier quoted context omitted.
Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.
The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but y…
> Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss?
Have alcoholics using Naltrexone? Or opioid addicts using Methadone, or smokers using nicotine gum/patches?
See I'm bringing this up to point out the obvious double standard, people suffering from food addiction (i.e. literally the high from food) or binge-eating disorder, who finally have an effective treatment, are treated like it isn't addiction or illness, but a "lifestyle," but if you said this stuff about any other addiction people would call you out and be horrified.
For people mildy overweight or accidentally obese, it is a wildly different illness for people with lifetime problems who have lost/regained weight tens of times and likely know more about nutrition than most healthy-weight people ever will.
Re: How long til we're all on Ozempic?
#496Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…
If you have an open mind, I'd like to assign you some homework if you like. Take a look around r/zepbound and count the following: 1. Posts from folks who diet+exercise, or who have tried diet/exercise and nothing's worked so they then turned to Zepbound ("excited to hit the gym," "my diet is finally starting to work with Zepbound" and similar) 2. Posts from folks who haven't tried diet/exercise and turned to Zepboun…
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Re: How long til we're all on Ozempic?
#497Earlier quoted context omitted.
I'm not sure how this applies to my comment. I'm not saying anything about self control. I'm not against individuals taking GLP-1s. But, if we're at a point where we're all on drugs to treat lifestyle diseases, we should at least recognize that these lifestyles are largely chosen for us , and we should consider that doing something about that will reap us the benefits we're after.
> these lifestyles are largely chosen for us >> Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. At what point do people stop letting the choice being largely "made" for them and choose something else? The gov subsidy has nothing to do with my personal health choices. My…
I'm happy you don't live in a food desert, live in a good neighborhood and have the means to move somewhere else if you wanted to. Not everyone has these advantages. I think we can all agree that these are good things and I hope we will do what we can to allow others enjoy them as well, because no one chooses to be in that situation, but it is largely a policy choice to keep it that way.
Re: How long til we're all on Ozempic?
#498> How long til we're all on Ozempic? It's genuinely quite depressing that so many people in the United States have a weight problem that the overwhelming majority of the population would benefit from this and headlines including "we are all" are not inaccurate. I don't think other countries are necessarily perfect here, but 74% of Americans don't have a healthy weight when you look at their BMI. That's a staggering s…
It really is a sad situation. As an American who spent the first 30 years of life in the US and over 20 in Europe, the difference is striking. However... here in the UK I see more and more "American-sized" people every year. _Something_ is changing. In the food and/or habits of the average Brit.
Anecdotally I would say Europeans as whole are getting ever so slighty larger. But just not at the rate as Americans. Ozempic seems like a god-send.
Re: How long til we're all on Ozempic?
#499Earlier quoted context omitted.
That's not even close to true. I can easily pop into HN for 5 minutes while taking a mental break at work, that's not an option (and would be utterly ineffective) for the gym.
If you truly only have 5 minutes of free time in your entire week, then why is it ineffective to do 5 minutes of pushups? That’s a lot of pushups.
> If you truly only have 5 minutes of free time in your entire week,
I was responding to your claim that if you can browse HN you can go to the gym, and it's obvious with any sort of thought that they are not similar activities.
> then why is it ineffective to do 5 minutes of pushups?
What is your goal? Fitness or weight loss? Either way, that won't be effective. Sure, it can be part of a larger fitness regimen, but just 5 minutes of push-ups ain't cutting it.
Re: How long til we're all on Ozempic?
#500Earlier quoted context omitted.
Studies have show most people rapidly regain the weight once they stop taking GLP-1 drugs. The dysfunctional biochemical processes that contributed to overeating are still present if you discontinue the drug. Your body has a natural set-point for the weight it wants to be at, and the hunger and food noise comes right back as your body tries to get you back to your old weight. It's possible that after after a long eno…
Is the idea of a set-point settled medical/scientific fact, or still a disputed theory?
Set-point theory is pretty much settled medical fact. The mechanism involves leptin, and you can easily see processes that defend bodyweight change in both directions. Though it will more aggressively defend weight loss than weight gain.
In addition prey animals will defend against weight gain more aggressively than non-prey animals. Which makes sense from an evolutionary standpoint. If a lion gets fat he doesn't have nearly as much to worry about than if a gazelle gets fat.