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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#431

Post by fireflash38 »

mlsu wrote: post #381
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…

For some people it is clinical. For others it is mental/willpower. That said... It's exceptionally difficult in the modern world to do everything necessary to be at a healthy weight. Things are shoved at you constantly that are terrible for you. It's so, so much easier to eat poorly and to excess. Combine that with dopamine hits from consuming sugar/fat? No surprise people overeat.

Re: How long til we're all on Ozempic?

#432

Post by anigbrowl »

unkoman wrote: post #388

Most of us should probably be on appetite suppressors due to the industrial revolution making food more than abundant while pumping it full of empty calories.

Just eat regular food. Hardly anything in my diet would be mysterious to a time traveler from 100 years ago, or indeed 200 years ago. Occasionally I enjoy chocolate or instant noodles but mostly it's just fruit, veg, meat, dairy, and grains. If you don't know what something is made out of or how, then don't eat it.

Re: How long til we're all on Ozempic?

#433

Post by itronitron »

cactusplant7374 wrote: post #402
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

> I realized that frequent cannabis consumption interferes with the weight loss Because you eat more or is there some other factor?

[flagged]

Re: How long til we're all on Ozempic?

#434

Post by hilux »

Living a healthy lifestyle, so that you won't need Ozempic, is possible - even surrounded by all the drugs and booze and carbs.

I do it. Lots of people do it. The information is freely available, now more than ever.

From all I've read, Ozempic isn't a silver bullet, and has many side effects. It just helps people stave off the inevitable for a while.

Re: How long til we're all on Ozempic?

#435

Post by pixl97 »

sss111 wrote: post #6
IncreasePosts wrote: post #3

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

There were several side effects related to pancreatic cancer associated with the precursors to GLP-1 drugs. The same companies promoting GLP-1s were responsible for driving up insulin prices. So I'm hedging my bets. There's a really cool Modern MBA video [1] on this topic btw :) [1]: https://www.youtube.com/watch?v=7sUoZVke_30

>Large epidemiological studies have shown the link between obesity and pancreatic cancer. A large population-based case-control study of pancreatic cancer demonstrated that obesity was associated with a statistically significant 50–60% increased risk of pancreatic cancer.

So does obesity, so there is that.

Re: How long til we're all on Ozempic?

#436

Post by yieldcrv »

robohydrate wrote: post #324
yieldcrv wrote: post #309

Earlier quoted context omitted.

Sounds like a kickstart you needed! Aside from the disruption in cravings, the immediate results seem to have motivated you to do more.

You can't imagine how empowering it is to be able to say "No." to food. I stopped eating dessert except once a week. I can be in the company of other people and surrounded by delicious food and not feel the compulsion to eat until I am nauseous.

This is interesting as this is my default, and I am pretty lean. I often have to remember to eat or check if I did, and lament that its a chore. I enjoy food and the dining experience, but I would be fine with that being an entertainment option once a week too.

I wonder if there is enough research on how gut bacteria influences these things, because if this is what people want maybe I could sell mine.

Re: How long til we're all on Ozempic?

#437

Post by cultofmetatron »

hyggetrold wrote: post #268
supportengineer wrote: post #260

Earlier quoted context omitted.

There's plenty of high quality food, you just have to know where to look. For example, come to the Bay Area and check out Whole Foods and any number of high-end restaurants.

+1 to this - what Europeans consider "the basics" for most Americans is filed under "luxury" or "bougie."

was in greece for three months. the quality of the BASIC fruits and vegetables at the regular local market down the street from where I was staying was on par with wholefoods. It was surreal how cheap it was to eat HEALTHY.

Re: How long til we're all on Ozempic?

#438

Post by r00fus »

cortesoft wrote: post #359
Uehreka wrote: post #271

Earlier quoted context omitted.

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Its a pretty well known fact that exercise alone (unless you are doing extreme athlete training) is not going to change your weight without a change in diet. You can get healthier with exercise, but not smaller. That is almost entirely based on diet. Just think about it; your thirty minutes of running probably burned between 300-500 calories. That one protein bar probably has about 300 calories by itself.

And that's where the GLP-1 meds come in. You get physically sick from eating your current (oversized) meal size. You don't have cravings. You can lose weight using GLP-1 even if you don't exercise strenuously/daily. However you lost a lot more if you have a regimen.

Re: How long til we're all on Ozempic?

#439

Post by Dumblydorr »

apsec112 wrote: post #8

This compares Ozempic with past drugs, but sales of past drugs are almost always limited by demand. I'm not sure there's much to learn here for a drug that is limited by supply. Also, this part is silly: "The announced investments across both companies total $32 billion. GLP-1s were 71% of Novo’s revenue in 2023, 16% of Lilly’s in 2023, and 26% of Lilly’s in 2024Q1. If these sales are proportional to the manufacturin…

Not fully true- orphan drug status exists for rare diseases and gives advantages to companies who develop drugs for rare conditions. This includes longer exclusivity periods amongst other incentives, rendering these categories more feasible economically.

Re: How long til we're all on Ozempic?

#440

Post by marcosdumay »

dyauspitr wrote: post #376
vessenes wrote: post #313

Earlier quoted context omitted.

Tirzepatide and Semaglutide are both known to reduce addiction / substance ingestion. I noticed I was just less interested in Alcohol when I started on Wegovy, and didn't realize it's a common effect until much later. I retained most of my disinterest after going off, too, FWIW.

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

Except for all the externally imposed ones.

But yes, there's a reason people are celebrating those drugs.

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