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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#471

Post by JamesBarney »

Alupis wrote: post #457
dyauspitr wrote: post #376

Earlier quoted context omitted.

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but y…

>If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance.

Longterm glp-1 agonist research doesn't agree with this.

> but you have to continue that lifestyle after stopping the drug.

Why stop the drug?

>Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss?

A small % of people are able to achieve significant weight loss with diet and exercise. And an even smaller % of that group are able to maintain it for the long term. We've been trying to solve obesity this way for a 50 years and have bubkis to show for it. If someone has high cholesterol we give them a statin, if they have high blood sugar we give them diabetes. Now if they're overweight we give them ozempic.

Re: How long til we're all on Ozempic?

#472

Post by perching_aix »

Alupis wrote: post #457
dyauspitr wrote: post #376

Earlier quoted context omitted.

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but y…

Sounds like it directly affects their lifestyle though? Being less drawn to addictions, and thus less engaged in related activities, is a pretty big lifestyle change.

Re: How long til we're all on Ozempic?

#473

Post by scottyah »

mlsu wrote: post #381
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…

The fact that a drug can cause a shortcut is completely normal I think, alcohol can nearly instantly give you the confidence that months of training would take, hallucinogens can give states of mind that monks spend years meditating and breathwork to achieve, steroids give shortcuts to massive gym gains, etc.

I see Ozempic as "taking the easy way out" the same way I see steroids as "taking the easy way out" (except it brings people closer to the norm of a average healthy person and will probably lengthen lifespans).

If you're in it to show mental fortitude for internet/social points, then it is "cheating", but if you're just in it for results it's perfectly acceptable and even recommended.

Re: How long til we're all on Ozempic?

#474

Post by dullcrisp »

op00to wrote: post #461
itronitron wrote: post #423

Earlier quoted context omitted.

[flagged]

The experience in that comment is literally my experience w/ a GLP-1 Agonist! Poop fart dong gobbler. A marketing team wouldn't write that, though, so you can believe me!

A scrappy marketing team though

Re: How long til we're all on Ozempic?

#475

Post by beagle3 »

kps wrote: post #453
mayukh wrote: post #391

Earlier quoted context omitted.

Obesity is a side effect of the industrial food production system in advanced economies that is slowly spreading all over the globe. How about alcohol and smoking ? Is that the same as obesity then

> Obesity is a side effect of the industrial food production system in advanced economies that is slowly spreading all over the globe. Yes, for the first time in the millions of years of existence of humanity and pre-humanity, we consistently have enough to eat.

Is not just “having enough”. People in New York had enough to eat for more than 60 years now - more like a 100 years. And ywt, up until the 1980s, obesity was a minor problem.

All standards have since changed. I watched the 1st season of the Simpsons again recently. In one of the episodes, Homer weighs himself and is distressed when discovering he weighs 200 lbs. 30 years later, dieters who cross down from 200 lbs to 199 lbs call it “reaching onederland” and it is considered a huge success.

Re: How long til we're all on Ozempic?

#477

Post by whall6 »

SketchySeaBeast wrote: post #322
whall6 wrote: post #278

Earlier quoted context omitted.

[flagged]

That's not even close to true. I can easily pop into HN for 5 minutes while taking a mental break at work, that's not an option (and would be utterly ineffective) for the gym.

If you truly only have 5 minutes of free time in your entire week, then why is it ineffective to do 5 minutes of pushups?

That’s a lot of pushups.

Re: How long til we're all on Ozempic?

#478

Post by julianeon »

IncreasePosts wrote: post #3

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

But consider the tradeoff: it's okay to have serious health issues in 30 years, if you were projected to die in 20 years without it.

Re: How long til we're all on Ozempic?

#479

Post by marcosdumay »

downrightmike wrote: post #394
lol768 wrote: post #319

> How long til we're all on Ozempic? It's genuinely quite depressing that so many people in the United States have a weight problem that the overwhelming majority of the population would benefit from this and headlines including "we are all" are not inaccurate. I don't think other countries are necessarily perfect here, but 74% of Americans don't have a healthy weight when you look at their BMI. That's a staggering s…

We're all depressed and overworked and have been for decades. Food is an escape

Add forced sedentarism into that set.

This is not exclusive to the US. The world is trending towards those, and different countries seem to only be at different distances from it, but the same velocity.

Also, industrialized food seems to be much more effective in causing dependency. Food preparation has overwhelmingly shifted into less healthy alternatives (even when they sound healthier in a naive review)... And there's a multitude of low probability high impact possible contributors that nobody knows if are important or not.

Re: How long til we're all on Ozempic?

#480

Post by davio »

rory wrote: post #428
cubefox wrote: post #110

Earlier quoted context omitted.

And apparently the pure manufacturing cost for Ozempic is relatively low: > the active drug in Ozempic can be produced for about 29 cents for a month’s supply, or 7.2 cents for a typical weekly dose, the research found. It’s not cheap to make — semaglutide costs over $70,000 per kilogram. But only a tiny quantity of the drug is used in each weekly dose. > https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nor..…

By chance I just talked to someone with deeper knowledge on this and they said the current constraint is actually ramping up supply of the delivery mechanism, not the drug. I have zero expertise on this, but would be curious if anyone knows what's special about Ozempic delivery that can't be served by a commodity syringe.

hims sells the generic version for a fraction of the price but you have to do regular injections
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