Live data from Hacker News

How long til we're all on Ozempic?

asteriskmag.com

241–250 of 1001 posts

Re: How long til we're all on Ozempic?

#241

Earlier quoted context omitted.

As with everything I'm sure there is a spectrum. There are surely folks who have food addictions, there are surely folks who are not taking accountability for their habits, and there are possibly folks for whom this could be the best or safest option.

[flagged]

What a naive way of looking at things. Sure, everyone that's fat is lazy! There cannot be any other explanations, right?

You seemingly forget not everyone is as privileged as you are. Clearly by your take, you can afford to eat healthy and have the leisure time to exercise. A lot more people can't.

Re: How long til we're all on Ozempic?

#242

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

> I'm not getting any of the benefits because I'm not overweight.

You’re already benefiting.

Re: How long til we're all on Ozempic?

#243
post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

I'm glad for RFK Jr. for this reason. Nobody talked about this in the mainstream conversations in the past.

People and officials have been talking about healthy eating for generations. Hard to get more mainstream than every doctor talking about diet and exercise.

Re: How long til we're all on Ozempic?

#244

Earlier quoted context omitted.

In 2021 I lost a good chunk of weight the old fashioned way. From 250ish to 215. I did it with "good old fashioned working out and not eating more". It was a miserable, white-knuckle experience. I was eating healthy food, enough calories (moderate but sane deficit), but the only thing I thought about at all moments was getting to the next meal. What snack is low enough calories to have to make it. It was miserable. A…

> I still work on eating healthy, but now I'm not just HUNGRY at all moments. I think this is something a lot of people pushing back against the GLP-1 agonists don't realize because they don't experience it: back before I started Mounjaro (another GLP-1 agonist) I was constantly hungry if I hadn't eaten a meal in the last 45 minutes. Absolutely zero hyperbole there - I once went to an all you can eat buffet, ate unti…

As someone who's never struggled with weight, it's been eye opening to hear how food focused a lot of peoples thoughts are. It was like on the same level as finding out some people can't visualize things in their minds.

Re: How long til we're all on Ozempic?

#245
post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

This is like saying, "All things being equal, I'd prefer Santa Claus bring presents on Christmas Eve than have to go shopping for my kids." It's like well duh of course you'd prefer the impossibly unrealistic miracle.

Of course it is impossible to live a healthy lifestyle and have healthy weight, if you ignore the 3/5ths of Americans that are not obese and the 7/8th of the global population.

Re: How long til we're all on Ozempic?

#246

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

> Studies show it just doesn't work.

Eating less and exercising most certainly does work, if the individual sticks to the routine.

I do agree it's difficult to stick to a routine because our modern lives are demanding and so we compromise by eating fast food and avoid going to the gym.

I think the exercise paradox video recently put out by Kurzgesagt has been a net negative for how people think about diet and exercise. The paper the video is based on is highly flawed.

That paper has a few major problems but these are the biggest:

1) The authors didn't control for body mass. The Hadza and Bolivians burned 52kcal per kg of body weight. Americans burned only 38kcal per kg of body weight. That is: the active groups burned significantly more calories than the inactive groups, on a pound-for-pound basis.

2) The active groups were defined as such because they walked ~12km per day. This is significant because the human body is exceptionally efficient at walking. It is certainly true that over a comparable span of time, you will burn less calories walking than you would running, or lifting weights.

GLP-1's are miracle drugs and people should take them if they at are high risk for obesity-related diseases.

But diet and exercise certainly do aid weight loss, and will have fewer negative side effects than a GLP-1 drug.

https://www.germanjournalsportsmedicine.com/archive/archive-...

Re: How long til we're all on Ozempic?

#248

I think Ozempic is a treatment of a symptom but not the underlying condition, but unlike many of the posters here, I do not think the underlying condition is "obesity". The below is mostly speculation. Research especially into people with healthy body weight seems to indicate that there is something going on that is causing widespread obesity. That is, there's some sort of environmental "GLP-1 Turbocharger". Maybe it…

You think ozempic is counteracting this mystery force and it is mere unrelated coincidence that it results in eating substantially less?

Re: How long til we're all on Ozempic?

#249
post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

What is a realistic path to this? Being from Europe I visited US last year and was horrified at the quality of your food. You see a lot of documentaries/youtube videos/etc... discussing the problem, but how do you even go about this?

Re: How long til we're all on Ozempic?

#250

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

Homeostasis is a powerful force. Once you gain weight your body has a tendency to keep it, and overcoming that to establish a new equilibrium is difficult and uncomfortable.
Post reply on HN