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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#231

It will be interesting to see how health insurance companies deal with Ozempic. A few days ago a top article on HN posed the question: Millions of Americans could benefit from drugs like Ozempic; will they bankrupt the healthcare system? Of course there are many health benefits to losing weight. Given there are clear, healthy, non-drug assisted ways to lose weight, should drug-assisted weight loss be considered an 'e…

The cost of someone being on Ozempic is going to be miles less than treating fatties for all the related obesity problems.

Re: How long til we're all on Ozempic?

#232

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

People need to understand what activity / exercise really is. The desperation of the medical establishment to get people to do ANY exercise meant the general advice is watered down.

It's the doom of the statistical distribution. Good outcomes are defined in relative terms on the bell curve, not on absolute performance which exercise is actually suited for.

In days of manual labor jobs and lots of walking, people likely burned 1500-4000 calories more per day than sedentary modern lifestyles. I can imagine farmers back in the days of 12-hour days of physical labor may burn 5000 or 6,000 calories. A pound of fat is 3500 calories.

Meanwhile, people that are generally following some 20 minutes of exercise five times a week, regimen of the medical establishment are likely really only burning about 300 to 400 calories tops in those 20 minutes sessions, if they even do that.

For the sake of argument, we're going to ignore the basal metabolic advantages of people that are burning an extra 1,500 to 3000 calories per day and the stimulated muscle growth that comes with it.

People back in olden days just on activity were burning a third to a half a pound extra of fat per day in terms of energy.

Meanwhile, modern people who "exercise" are burning maybe a tenth of a pound. Only when you get to "athletes" that are "training" do you get to the calorie burns that people's lives used to entail.

So it's important to keep in mind when people say exercise is ineffective in weight loss that they really are talking about very minor amounts of added activity by by modern medical standards.

Exercise is extremely effective at limiting weight if you get to what I call the 1000 calorie Hammer, where your exercise is adding an extra thousand calories or more per day to your activity. And you're simultaneously not going nuts on your diet.

A 1000 calories is a considerable amount of activity. For a 180 lb man, that's 4000 yards of swimming, 7 miles of running, or 25-30 miles of biking.

If you are a 120 lb woman, increase those distances by 50%. Most people consider those loads to be exercise obsessives, but practically that's what's necessary in order to employ exercise as a usable means for weight control and surviving the corn syrup world we're in

Re: How long til we're all on Ozempic?

#233

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

Has there ever been a case where something like #2 has happened? Don't think you need to worry about that one.

There are some evidence that Ozempic/Wegovy actually cures more addictions than just food addiction.

    >The weight-loss jabs have apparently helped people kick habits from smoking to shopping, although scientists remain wary about recommending it as an addiction treatment
https://www.theatlantic.com/health/archive/2023/05/ozempic-a...

Re: How long til we're all on Ozempic?

#234

Earlier quoted context omitted.

[flagged]

I've struggled with weight loss my entire life. It's gotten to the point where I'm on multiple blood pressure medications, and the dosages are creeping up. And yet I still find myself thinking about eating constantly. Then I took Zepbound. It was revelatory. It was like a curse was lifted, and my hunger was silenced. I'm down 45 lbs in 4 months. Perhaps if I didn't have responsibilities or trauma or stress or a thous…

> Perhaps if I didn't have responsibilities or trauma or stress or a thousand other things I could put all my energy into self control.

This is so relatable. Right before Covid, I was working really hard at counting calories and was looking at going below 200 lbs for the first time in my adult life. Then Covid hit, my life was upended, and I prioritized other things; I'm up about 40 lbs from then.

I can only devote so much energy to this kind of intensive lifestyle change, and other things have been taking precedence (including, recently, working out—that's been a huge lifestyle improvement [other than Wednesday being leg day and my legs still yelling at me], but hasn't led to weight loss).

Re: How long til we're all on Ozempic?

#235

Earlier quoted context omitted.

This is like saying, "All things being equal, I'd prefer Santa Claus bring presents on Christmas Eve than have to go shopping for my kids." It's like well duh of course you'd prefer the impossibly unrealistic miracle.

Other countries do it. https://en.wikipedia.org/wiki/Change4Life

Is there any evidence it’s effective?

https://en.m.wikipedia.org/wiki/Obesity_in_the_United_Kingdo...

Re: How long til we're all on Ozempic?

#236

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

I’m skeptical of the idea that across the general population we’d be healthier if we dialed up our insulin production. Serious question but has there ever been a case of humans benefitting from increasing a hormone like this? Since it’s an injection, It wouldn’t be a steady increase, but more likely have bursts of it. I don’t know how healthy that would be in the long run. After what happened with OxyContin I think w…

GLP-1's have been around since 2005. Exenatide.

They're not new.

Re: How long til we're all on Ozempic?

#237
A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives.

Ozempic and Wegovy are game changes and have real, tangible health benefits.

One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

Re: How long til we're all on Ozempic?

#238

Earlier quoted context omitted.

As with everything I'm sure there is a spectrum. There are surely folks who have food addictions, there are surely folks who are not taking accountability for their habits, and there are possibly folks for whom this could be the best or safest option.

[flagged]

Who cares? If someone needs to eat less to get healthy, they can do that and: be miserably hungry or not.

It's like telling people they can't have aspirin during a hangover.

Re: How long til we're all on Ozempic?

#239
I think Ozempic is a treatment of a symptom but not the underlying condition, but unlike many of the posters here, I do not think the underlying condition is "obesity". The below is mostly speculation.

Research especially into people with healthy body weight seems to indicate that there is something going on that is causing widespread obesity. That is, there's some sort of environmental "GLP-1 Turbocharger".

Maybe it relates to processed food, maybe it relates to microplastic contamination, maybe it's in the cheese, maybe it's an innocuous viral agent, maybe it's gut biome, maybe it's ADHD drugs, maybe it's SSRIs.

I suspect that Ozempic is helping us get back to a baseline level of exposure by counteracting this. And in the future if we're lucky we'll figure out what it is and try to correct it at the source.

Re: How long til we're all on Ozempic?

#240

It will be interesting to see how health insurance companies deal with Ozempic. A few days ago a top article on HN posed the question: Millions of Americans could benefit from drugs like Ozempic; will they bankrupt the healthcare system? Of course there are many health benefits to losing weight. Given there are clear, healthy, non-drug assisted ways to lose weight, should drug-assisted weight loss be considered an 'e…

The cost of someone being on Ozempic is going to be miles less than treating fatties for all the related obesity problems.

Yeah, right now the cost of the drug itself is high, but as that comes down and/or once the patents expire, it's a no brainer for insurance companies to fund it, in the same way that even the worst health insurance plans usually allow for cheap office visits and free flu vaccinations.
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