181–190 of 1001 posts
Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…
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In 2021 I lost a good chunk of weight the old fashioned way. From 250ish to 215. I did it with "good old fashioned working out and not eating more". It was a miserable, white-knuckle experience. I was eating healthy food, enough calories (moderate but sane deficit), but the only thing I thought about at all moments was getting to the next meal. What snack is low enough calories to have to make it. It was miserable. A…
> I still work on eating healthy, but now I'm not just HUNGRY at all moments. I think this is something a lot of people pushing back against the GLP-1 agonists don't realize because they don't experience it: back before I started Mounjaro (another GLP-1 agonist) I was constantly hungry if I hadn't eaten a meal in the last 45 minutes. Absolutely zero hyperbole there - I once went to an all you can eat buffet, ate unti…
I don't have any eating issues but that reminds me of the first time I went on a 7-day cruise.
There's nothing to do on the ship, and the food is free and pretty tasty, so... I basically ended up at the buffet eating and drinking all day long. Sausage and egg biscuits, banana bread, pot roast, steak, pasta, fried rice, cinnamon buns, they had everything. I was stomach-busting full, every minute of every day. I'd gorge myself on a huge plate of Indian food from the buffet, and then a few hours later head to another deck for a lobster dinner. Not to mention, drinking coffee, beer, and wine the entire time.
It was kind of insane. And what was crazier was after a few days of this routine I got used to it, and even looked forward to eating more food the next day. It was sort of like directly embracing one of the seven deadly sins to the maximum extent possible. I'm not sure what that experience means other than it seems like the the human body can comfortably arrange itself into a habitual downward cycle fairly rapidly.
It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.
I've been on wegovy for almost two years now, and I can attest to how much you just DONT want to eat junk anymore. It's one of the most commonly talked about things we discuss with other users over the last few years. That and lower want to drink, and gaining back so much of energy/time due to not having to think about food every 3 seconds of the day. I'm super satisfied just having an apple or two now. The "omg I ne…
Glad you're seeing benefits like that!
My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.
But for fat people, the calculus looks different.
A decision to take semaglutides is a decision between the long-term negative effects of obesity *now*, or the possibility of long-term negative effects *later.*
Anecdotally, trans people have a similar calculus. Going unmedicated/unsupported brings significant mental health risk now[1], whereas going on hormone replacement may or may not cause complications much later in life (osteoperosis, hepotoxicity issues for some treatments, etc).
Either way, you gotta get to the "later in life" part before you can worry about the outlook there.
1: a CDC meta-review said that 26% of surveyed US trans students attempted suicide this year, N=20,103 surveyed, ~660 of which were trans. https://archive.ph/0H81G
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> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…
It would work if people would actually do it. It 100% works. Human nature is such that people would rather take a drug than change their lifestyle. I've done it myself but it requires a complete realignment of lifestyle to make lasting change.
I’m just as curious as to why some people are so willing to take numerous medications, while others go to any lengths to avoid them. Some people are happy to be on an SSRI, sleeping pill, statin, low dose aspirin, and a few others, and aren’t bothered by this. Other people seem instinctively revolted by prescription drugs, seeing toxins pushed by evil corporations. Is it a trust issue? I personally detest and avoid a…
> Other people seem instinctively revolted by prescription drugs, seeing toxins pushed by evil corporations. You can advertise drugs on TV in the USA. This certainly opens the door for bad drugs to get pushed out and marketed to people who don't have the technical skills to examine the claims and the risks of side effects objectively. > avoid all medicines other than antibiotics and vaccines Just because it's been su…
The cosmetic narrative you're pushing is actually quite disgusting.
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Sure, but the "unhealthy but not excessively caloric" diet is not a problem ozempic attempts to address. As far as I understand, it simply limits your appetite. Potentially one can go on ozempic, lose weight, and still end up eating unhealthily, because the resulting diet is made up of nutritionally poor foods.
And the argument you are replying to is that it's just covering up a symptom and not addressing the root problem holistically. Ozempic isn't a fix, it's a bandaid.
My friends and I all live outside of the USA and we can get basically unlimited ampoules of powdered Mounjaro from China. It is very simple to reconstitute with Sterile water in a no touch way and works great. We have all had significant weight loss and improvement in blood pressure and glucose levels etc.
Waiting for these companies to get their act together, especially when mounjaro is a copycat drug is not acceptable. these drugs are biochemically very simple peptides with a couple of cross linkages and very easy to make in high quantities so there is no excuse for everyone who needs them to not be on them. a large portion of the world not having access to these drugs for the patent period and continuing to suffer all the effect of obesity is not morally acceptable.
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> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…
>>>Studies show it just doesn't work. It's not that "eat less and exercise more" doesn't work, it's that nobody does it, because it's really, really hard. Calories in/Calories out is both completely true and completely useless for actual humans. edit: that's unfair, mostly useless