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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#171

Post by potta_coffee »

arcticbull wrote: post #105
rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

It would work if people would actually do it. It 100% works. Human nature is such that people would rather take a drug than change their lifestyle. I've done it myself but it requires a complete realignment of lifestyle to make lasting change.

Re: How long til we're all on Ozempic?

#172

Post by kelseyfrog »

mrweasel wrote: post #96
kelseyfrog wrote: post #24

Earlier quoted context omitted.

From my understanding GLP-1 agonists can actually modulate the reward pathway reducing people's appetite for toxic diets. We're not socially caught up yet to this information. I suspect there are folks who believe that regardless of similar outcome (reduction of toxic diet), that changing diet without medication is superior to those who change their behavior through pharmacological intervention. It's like the pre-199…

> GLP-1 agonists can actually modulate the reward pathway reducing people's appetite for toxic diets. There are also studies out showing that people just up their sugar intake, so I think the results on how it affects peoples diet is still pending. From what I've seen, people are eating less, but more of it is junk food and sugar. I can absolutely see why people would want to be able to just take a drug and start los…

> Arguably exercise is more important than your weight

I'm curious to hear the argument

Re: How long til we're all on Ozempic?

#173

Post by stevenAthompson »

patmcc wrote: post #138
arcticbull wrote: post #105

Earlier quoted context omitted.

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

>>>Studies show it just doesn't work. It's not that "eat less and exercise more" doesn't work, it's that nobody does it, because it's really, really hard. Calories in/Calories out is both completely true and completely useless for actual humans. edit: that's unfair, mostly useless

Right. It works, it isn't sustainable because it doesn't just take effort it takes effort multiplied by time (effort x time = permanent weight loss).

Obviously, even a small amount of effort becomes impossible when you multiply it by "forever".

Re: How long til we're all on Ozempic?

#175

Post by icedchai »

arcticbull wrote: post #105
rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

Of course, it "doesn't work" because people don't keep it up. I started exercising regularly during covid and didn't stop. I cut out all the soda. It works.

Re: How long til we're all on Ozempic?

#176

Post by mrweasel »

patmcc wrote: post #138
arcticbull wrote: post #105

Earlier quoted context omitted.

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

>>>Studies show it just doesn't work. It's not that "eat less and exercise more" doesn't work, it's that nobody does it, because it's really, really hard. Calories in/Calories out is both completely true and completely useless for actual humans. edit: that's unfair, mostly useless

Precisely, the point of Ozempic (or rather Wegovy, Ozempic is for type-1 diabetes) is that it reduces your appetite, making it easier to eat less.

One of the studies done with Wegovy showed that people lost 15% of their body mass in a year, but they also eat 500 Calories less and exercised for 2.5 hours a week.

Re: How long til we're all on Ozempic?

#178

Post by petesergeant »

optimalsolver wrote: post #100
BoingBoomTschak wrote: post #28

Earlier quoted context omitted.

Well, the negative consequence on the value of willpower is pretty obvious. "In what measure" is the real question.

You know the way that software bloat expands to consume increased computational speed? We're about to see the nutritional equivalent.

We're about to see a dramatic fall in the production and consumption of unhealthy food because people who used to want them in large quantities will no longer want them when they're on GLP-1 drugs.

Re: How long til we're all on Ozempic?

#179

Post by rmellow »

mritchie712 wrote: post #84
IncreasePosts wrote: post #3

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

Has there ever been a case where something like #2 has happened? Don't think you need to worry about that one.

Adding iodine to salt has greatly increased the population's IQ in countries that have adopted it.

https://pubmed.ncbi.nlm.nih.gov/15734706/

Re: How long til we're all on Ozempic?

#180

Post by vundercind »

indiebat wrote: post #17

I don’t want this to come out insensitive or from under the rock, but why is taking a drug a novel & cool idea (all of a sudden/recently) as opposed to good old fashioned working out and not eating more than what you need? okay, this drug is all kinds of great and it’s the next best thing since green grapes, still not eating more and workout is better than taking drugs that effect your brain right? Are doctors requir…

Willpower and discipline don’t seem to be what keeps other countries skinnier than the US (and most of them are also getting fatter…) so I don’t know why we expect that to get the US out of this mess.

Evidence: people from skinnier countries move here and consistently get fatter. It’s a societal/environmental problem, if we’re talking about “what would a policy fix look like?” and not “what can I personally try to do to save myself despite being up against a societal/environmental problem?”

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