Scientists discover a cause of lupus, possible way to reverse it • Hacker News Board

Re: Scientists discover a cause of lupus, possible way to reverse it

#191

Post by woleium » Fri, Jul 12, 2024, 7:27 PM UTC

nanomonkey wrote: post #176

skrebbel wrote: post #152

Earlier quoted context omitted.

> after years of not eating anything with fiber, You mean they avoided vegetables entirely?

Yes, there is a whole subsection of the internet that seems to think that vegetables are a net negative. They site doctors that suggest that fiber causes irritation in individuals with compromised intestines (leaky gut syndrome, etc.). It's exhausting having conversations with them as a vegetarian as they seem to think the only healthy way to eat is bone broth, butter, mct oil, and meat.

it’s probably _a_ way. The Saami live like this, with some berries for vit c.

I wouldn’t want to do it though!

Re: Scientists discover a cause of lupus, possible way to reverse it

#192

Post by daftego » Sat, Jul 13, 2024, 12:46 AM UTC

A question I threw at AI about the bodies production of AhR and how it relates to food

Glucosinolates seems to be a key compound for the production of AhR. Has anyone tried Sulforaphane Glucosinolate supplements?

This was its response.

AhR itself is not found in food, but certain foods contain natural compounds that can activate or modulate the activity of the aryl hydrocarbon receptor. Here is a list of foods that are known to contain high concentrations of AhR activators:

Cruciferous Vegetables

  * Broccoli: Contains glucosinolates, which are converted to indole-3-carbinol, an AhR activator.
  * Brussels Sprouts: Rich in glucosinolates and indole-3-carbinol.
  * Cabbage: Contains glucosinolates and their breakdown products that can activate AhR.
  * Cauliflower: Another cruciferous vegetable high in glucosinolates.
  * Kale: Contains a variety of phytochemicals, including indole-3-carbinol.

Berries and Fruits:

  * Blueberries: High in polyphenols, particularly anthocyanins, which can activate AhR.
  * Strawberries: Contain a variety of polyphenols and antioxidants.
  * Blackberries: Rich in anthocyanins and other polyphenols.
  * Grapes: Especially red and purple varieties, which are high in resveratrol and other polyphenols.

Spices and Herbs:

  * Turmeric: Contains curcumin, a known AhR modulator.
  * Garlic: Contains organosulfur compounds that can influence AhR activity.
  * Ginger: Contains gingerols and shogaols, which can modulate AhR.

Legumes and Beans:

  * Soybeans: Contain isoflavones like genistein, which can activate AhR.
  * Black Beans: High in various polyphenols.

Nuts and Seeds:

  * Walnuts: Contain a variety of polyphenols and antioxidants.
  * Flaxseeds: High in lignans, which can have AhR-modulating effects.

Teas and Beverages:

  * Green Tea: Contains epigallocatechin gallate (EGCG), a potent polyphenol that can activate AhR.
  * Red Wine: Contains resveratrol and other polyphenols.
  * Coffee: Rich in various polyphenols that can modulate AhR activity.

Other Foods:

  * Olive Oil: Particularly extra virgin olive oil, which contains polyphenols like oleocanthal.
  * Dark Chocolate: High in flavonoids and polyphenols.

Re: Scientists discover a cause of lupus, possible way to reverse it

#193

Post by nativeit » Sat, Jul 13, 2024, 4:09 PM UTC

xdrone wrote: post #157

aroopchandra wrote: post #126

I was diagnosed with lupus a few years ago. My mom also had it and passed away after 10 years due to complications. My initial symptoms were severe joint pains, which made daily activities difficult. This happened during the COVID lockdown, which helped me maintain my job. I did a lot of research and tried various treatments. Functional medicines and expensive vitamins didn’t help. I read about long-term fasting and…

In the vegan community there is lost of discussion of animal products causing auto immune issues. A compromised gut lining will let intact animal proteins into the body. The immune sees the animal foreigners but also attacks our body; us being animals too. Type 1 diabetes, aka childhood diabetes, is thought to be from casein in A1 milk; where the immune system attacks the beta cells of the pancreas. Seems plausible t…

So this is where the people come from who responded to my MS diagnosis with diet plans…I can tell you, despite their clearly good intentions, it was really annoying. Same kind of thing with faith healers. Come at me after you’ve got some reliable data from repeated double-blind controlled trials. Until then, I’m really not interested what kind of kale smoothies might help nerve pain and paralysis.

They also used really unhelpful citations, like “see: Finland”.

Feel free to continue this discussion here and within nutrition enthusiast groups, but please consider the perspectives of someone who’s struggling with a fresh, serious diagnosis before telling them all the hidden secrets of raw diets. Part of getting diagnosed is, at least for me, doing a shit ton of research to know better what my body is doing to me. Part of that research is sifting through all the scams and B.S. NaturalNews[TM] crap that, relevant or not, reads just like this thread. So when people tried to respond to the news of my illness with recipes it felt really patronizing and minimized my experience for the purposes of highlighting their hobby.

Just for an outside perspective. If any of this is backed with reliable data, I’m happy to read it.

Re: Scientists discover a cause of lupus, possible way to reverse it

#194

Post by nativeit » Sat, Jul 13, 2024, 5:54 PM UTC

valgor wrote: post #167

xdrone wrote: post #157

Earlier quoted context omitted.

In the vegan community there is lost of discussion of animal products causing auto immune issues. A compromised gut lining will let intact animal proteins into the body. The immune sees the animal foreigners but also attacks our body; us being animals too. Type 1 diabetes, aka childhood diabetes, is thought to be from casein in A1 milk; where the immune system attacks the beta cells of the pancreas. Seems plausible t…

Funny enough, I mentioned not eating meat on another hackernews thread today and someone told me I'm going to get an autoimmune disease.

This is a classic example, frequently paired with a bunch of pseudoscience and smart sounding nonsense. Even if it weren’t personally offensive to me as an MS patient (diagnosed in 2001, when I in my late teens, and not for nothing—a soccer player and vegetarian in otherwise very good physical shape) this kind of speculative alternative health stuff muddies the water so that when looking for legitimate, bonafide information for autoimmune disorders and treatments, one has to sift through vast torrents of frequently difficult to distinguish bullshit. They go out of their way to appear legit, spend tons of money to push dis-/misinformation, and/or poison the well of mainstream science and research.

I’m not suggesting that’s what’s happening in all of these comments, but I’ve seen a lot already that absolutely is. It’s really disappointing to see, but I’ve learned HN comments are great…until the topic of discussion departs from the usual tech-specific ideas, then it’s Dunning, Kruger, et al.

Re: Scientists discover a cause of lupus, possible way to reverse it

#195

Post by hinkley » Sat, Jul 13, 2024, 8:07 PM UTC

aroopchandra wrote: post #149

maayank wrote: post #147

Earlier quoted context omitted.

What do you eat for protein in the current diet? What was your experience with fish?

I eat a lot of legumes such as lentils, chickpeas, black beans, and peas. I also include tofu made from soy, and nuts like almonds, peanuts, as well as seeds like chia, flaxseeds, and hemp. I use plant-based protein powders too specifically ( https://lovecomplement.com/products/complement-organic-vegan... ) when I drink green smoothies (3 to 4 meals a week). Green leafy vegetables also has a lot protein (Kale, Brocco…

I never understood why the British had such a hardon for split pea soup until I looked at the nutrition. "Split peas" have a lot more protein than regular peas. Like two or three times as much.

As for the fish, you could try making yourself miso soup. Properly made, it contains bonito flakes, and it's impossible to overdo bonito flakes.

Re: Scientists discover a cause of lupus, possible way to reverse it

#196

Post by mzz80 » Sun, Jul 14, 2024, 7:15 AM UTC

nanomonkey wrote: post #176

skrebbel wrote: post #152

Earlier quoted context omitted.

> after years of not eating anything with fiber, You mean they avoided vegetables entirely?

Yes, there is a whole subsection of the internet that seems to think that vegetables are a net negative. They site doctors that suggest that fiber causes irritation in individuals with compromised intestines (leaky gut syndrome, etc.). It's exhausting having conversations with them as a vegetarian as they seem to think the only healthy way to eat is bone broth, butter, mct oil, and meat.

It’s common for someone in a flare of an IBD to be unable to eat vegetables without irritation. You should seek to understand the root cause of an individual’s experience instead of invalidating their experience due to your own.

If they become healthier then they should be able to increase vegetable intake which will further increase their health.

Re: Scientists discover a cause of lupus, possible way to reverse it

#197

Post by blackoil » Thu, Jul 18, 2024, 1:57 AM UTC

aroopchandra wrote: post #126

I was diagnosed with lupus a few years ago. My mom also had it and passed away after 10 years due to complications. My initial symptoms were severe joint pains, which made daily activities difficult. This happened during the COVID lockdown, which helped me maintain my job. I did a lot of research and tried various treatments. Functional medicines and expensive vitamins didn’t help. I read about long-term fasting and…

Unfortunately, role of food in human health isn't studied properly because of won't make anyone money.

Traditional Indian medicine and grandma's wisdom have a long list of foods to eat or not depending on disease/pregnancy/breast feeding etc. But there isn't enough scientific research on it.

Unfortunately the Internet has made it worse now everybody is peddling something or other.

Re: Scientists discover a cause of lupus, possible way to reverse it

#198

Post by notheyarent » Thu, Jul 25, 2024, 3:07 AM UTC

geewee wrote: post #88

notheyarent wrote: post #86

they aren’t cell diseases. It is plant toxins either leaking into the blood stream through intestinal permeability or a problem with peoples livers being fatty and not able to do their job anymore resulting in the bodies inability to remove plant toxins. The toxins cause an immune reaction wherever they build up , rheumatoid arthritis if it’s the joints of the legs and arms etc. Plant toxins include pesticides, fungi…

If these toxins build up in animal cells - why would you eating meat (that must then have a much higher concentration) not expose you to the same toxins?

[flagged]

Re: Scientists discover a cause of lupus, possible way to reverse it

#199

Post by notheyarent » Thu, Jul 25, 2024, 3:08 AM UTC

aroopchandra wrote: post #130

notheyarent wrote: post #86

they aren’t cell diseases. It is plant toxins either leaking into the blood stream through intestinal permeability or a problem with peoples livers being fatty and not able to do their job anymore resulting in the bodies inability to remove plant toxins. The toxins cause an immune reaction wherever they build up , rheumatoid arthritis if it’s the joints of the legs and arms etc. Plant toxins include pesticides, fungi…

For me, it was the opposite. Cutting out meat and eating a lot of organic greens helped calm my immune system and reduce inflammation. In my experience, meat increased my inflammation, while greens decreased it. I think everyone is different, and it's not hard to test on yourself if you have noticeable symptoms like joint pain, as I did.

[flagged]

Re: Scientists discover a cause of lupus, possible way to reverse it

#200

Post by notheyarent » Thu, Jul 25, 2024, 3:13 AM UTC

theferalrobot wrote: post #92

notheyarent wrote: post #86

they aren’t cell diseases. It is plant toxins either leaking into the blood stream through intestinal permeability or a problem with peoples livers being fatty and not able to do their job anymore resulting in the bodies inability to remove plant toxins. The toxins cause an immune reaction wherever they build up , rheumatoid arthritis if it’s the joints of the legs and arms etc. Plant toxins include pesticides, fungi…

Wouldn't then the cure just be to eat organic food, rather than meat of animals that were fed way worse crap than the average person? The whole premise makes no sense...

Some meats like chicken do cause flare ups for auto immune people because the chickens diets are full of crap food yes. Pork also causes a lot of people in these communities issues.

Cows on the other hand just eat grass or plain grains ... and have 7 stomachs filtering and cleaning their food.